A monoclonal antibody against KCNK9 K+ channel extracellular domain inhibits tumour growth and metastasis
Han Sun, Liqun Luo, Bachchu Lal and 7 more
Nature Communications · 2016
doi:10.1038/ncomms10339 (opens in a new tab)
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Abstract
The potassium channel KCNK9 mediates important biological processes and is often overexpressed in breast and lung cancers. In this study, the authors developed a specific monoclonal antibody against the extracellular domain of KCNK9 and show that it inhibits cancer growth and metastasis in vivothrough both cell autonomous and immune-dependent cellular cytotoxicity.
Abstract licence: CC BY-NC-ND
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