Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response
Julia Merkenschlager, Mickaël J. Ploquin, Urszula Eksmond and 6 more
Nature Communications · 2016
doi:10.1038/ncomms10281 (opens in a new tab)
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Abstract
During an immune response, CD4+ T cell repertoire is thought to increase in avidity at the expense of diversity. Here the authors show that B cells act as antigen-presenting cells to boost the development of low-avidity T cell clones, diversifying the T cell repertoire at late stages of the response.
Abstract licence: CC BY-NC-ND
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