mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2
KyeongJin Kim, Li Qiang, Matthew S. Hayden and 3 more
Nature Communications · 2016
doi:10.1038/ncomms10255 (opens in a new tab)
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Abstract
The protein raptor is a subunit of the mTORC signalling complex. Here the authors show that Raptor also exists in a free form, unbound to mTORC, and that this free Raptor negatively regulates hepatic Akt activity and lipid metabolism in mice via a mechanism involving the Akt phosphatase PHLPP2.
Abstract licence: CC BY-NC-ND
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