A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity
Lei Yuan, Gary C. Chan, David Beeler and 14 more
Nature Communications · 2016
doi:10.1038/ncomms10160 (opens in a new tab)
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Abstract
Spontaneous phenotypic heterogeneity confers a population-level advantage to cells that are exposed to fluctuating environments. Here the authors show that the endothelium of some organs displays a dynamic mosaicism in expression of Von Willebrand factor, suggesting bet hedging as a strategy for adaptive homeostasis.
Abstract licence: CC BY-NC-ND
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