Tissue-specific differentiation of colonic macrophages requires TGFβ receptor-mediated signaling

Abstract

Intestinal macrophages (mφ) form one of the largest populations of mφ in the body and are vital for the maintenance of gut homeostasis. They have several unique properties and are derived from local differentiation of classical Ly6C hi monocytes, but the factors driving this tissue-specific process are not understood. Here we have used global transcriptomic analysis to identify a unique homeostatic signature of mature colonic mφ that is acquired as they differentiate in the mucosa. By comparing the analogous monocyte differentiation process found in the dermis, we identify TGFβ as an indispensable part of monocyte differentiation in the intestine and show that it enables mφ to adapt precisely to the requirements of their environment. Importantly, TGFβR signaling on mφ has a crucial role in regulating the accumulation of monocytes in the mucosa, via mechanisms that are distinct from those used by IL10.

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• Network analysis of transcriptomic diversity amongst resident tissue macrophages and dendritic cells in the mouse mononuclear phagocyte system · 2020
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• Niche signals and transcription factors involved in tissue-resident macrophage development · 2018
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• Origin, Differentiation, and Function of Intestinal Macrophages · 2018
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• Dynamics of Colon Monocyte and Macrophage Activation During Colitis · 2018
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• Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression · 2018
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• Langerhans Cells—Programmed by the Epidermis · 2017
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• Macrophages in gastrointestinal homeostasis and inflammation · 2017
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