Elevated expression of the human ras oncogene family in premalignant and malignant tumours of the colorectum

Study of expression of ras-related oncogenes in human premalignant polyps and malignant tumours of the colorectum, as well as in normal colorectal mucosa, shows a significant elevation in the premalignant and malignant tissues as compared to their respective colorectal mucosa. These results suggest that activation of the ras oncogene family occurs in the development of colorectal tumours and that elevated expression at a premalignant stage may well be critical in the process of carcinogenesis but not in itself sufficient.

Abstract licence: CC BY

1. 1.

   Balmain A., Ramsden M., Bowden G. T., Smith J. Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas. Nature. 1984;307(5952):658-660.

   Not in our library10.1038/307658a0 (opens in a new tab)

2. 2.

   Chang E. H., Gonda M. A., Ellis R. W., Scolnick E. M., Lowy D. R. Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses. Proc Natl Acad Sci U S A. 1982;79(16):4848-4852.

   Not in our library10.1073/pnas.79.16.4848 (opens in a new tab)

3. 3.

   Collins S., Groudine M. Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line. Nature. 1982;298(5875):679-681.

   Not in our library10.1038/298679a0 (opens in a new tab)

4. 4.

   Dalla-Favera R., Gelmann E. P., Gallo R. C., Wong-Staal F. A human onc gene homologous to the transforming gene (v-sis) of simian sarcoma virus. Nature. 1981;292(5818):31-35.

   Not in our library10.1038/292031a0 (opens in a new tab)

5. 5.

   Denhardt D. T. A membrane-filter technique for the detection of complementary DNA. Biochem Biophys Res Commun. 1966;23(5):641-646.

   Not in our library10.1016/0006-291x(66)90447-5 (opens in a new tab)

6. 6.

   Ellis R. W., DeFeo D., Maryak J. M., Young H. A., Shih T. Y., Chang E. H., Lowy D. R., Scolnick E. M. Dual evolutionary origin for the rat genetic sequences of Harvey murine sarcoma virus. J Virol. 1980;36(2):408-420.

   Not in our library10.1128/jvi.36.2.408-420.1980 (opens in a new tab)

7. 7.

   Ellis R. W., Defeo D., Shih T. Y., Gonda M. A., Young H. A., Tsuchida N., Lowy D. R., Scolnick E. M. The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes. Nature. 1981;292(5823):506-511.

   Not in our library10.1038/292506a0 (opens in a new tab)

8. 8.

   Eva A., Robbins K. C., Andersen P. R., Srinivasan A., Tronick S. R., Reddy E. P., Ellmore N. W., Galen A. T., Lautenberger J. A., Papas T. S. Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells. Nature. 1982;295(5845):116-119.

   Not in our library10.1038/295116a0 (opens in a new tab)

9. 9.

   Goldfarb M., Shimizu K., Perucho M., Wigler M. Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells. Nature. 1982;296(5856):404-409.

   Not in our library10.1038/296404a0 (opens in a new tab)

10. 10.

    Gonda T. J., Sheiness D. K., Bishop J. M. Transcripts from the cellular homologs of retroviral oncogenes: distribution among chicken tissues. Mol Cell Biol. 1982;2(6):617-624.

    Not in our library10.1128/mcb.2.6.617-624.1982 (opens in a new tab)

11. 11.

    Goyette M., Petropoulos C. J., Shank P. R., Fausto N. Expression of a cellular oncogene during liver regeneration. Science. 1983;219(4584):510-512.

    Not in our library10.1126/science.6297003 (opens in a new tab)

12. 12.

    Hall A., Marshall C. J., Spurr N. K., Weiss R. A. Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1. Nature. 1983;303(5916):396-400.

    Not in our library10.1038/303396a0 (opens in a new tab)

13. 13.

    Jass J. R. Relation between metaplastic polyp and carcinoma of the colorectum. Lancet. 1983;1(8314-5):28-30.

    Not in our library10.1016/s0140-6736(83)91564-7 (opens in a new tab)

14. 14.

    Laskey R. A., Mills A. D. Enhanced autoradiographic detection of 32P and 125I using intensifying screens and hypersensitized film. FEBS Lett. 1977;82(2):314-316.

    Not in our library10.1016/0014-5793(77)80609-1 (opens in a new tab)

15. 15.

    McCoy M. S., Toole J. J., Cunningham J. M., Chang E. H., Lowy D. R., Weinberg R. A. Characterization of a human colon/lung carcinoma oncogene. Nature. 1983;302(5903):79-81.

    Not in our library10.1038/302079a0 (opens in a new tab)

16. 16.

    McGrath J. P., Capon D. J., Smith D. H., Chen E. Y., Seeburg P. H., Goeddel D. V., Levinson A. D. Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene. Nature. 1983;304(5926):501-506.

    Not in our library10.1038/304501a0 (opens in a new tab)

17. 17.

    Minty A. J., Alonso S., Caravatti M., Buckingham M. E. A fetal skeletal muscle actin mRNA in the mouse and its identity with cardiac actin mRNA. Cell. 1982;30(1):185-192.

    Not in our library10.1016/0092-8674(82)90024-1 (opens in a new tab)

18. 18.

    Morson B. C. Evolution of cancer of the colon and rectum. Cancer. 1974;34(3):suppl-suppl:849.

    Not in our library10.1002/1097-0142(197409)34:3+<845::aid-cncr2820340710>3.0.co;2-h (opens in a new tab)

19. 19.

    Müller R., Slamon D. J., Tremblay J. M., Cline M. J., Verma I. M. Differential expression of cellular oncogenes during pre- and postnatal development of the mouse. Nature. 1982;299(5884):640-644.

    Not in our library10.1038/299640a0 (opens in a new tab)

20. 20.

    Müller R., Verma I. M., Adamson E. D. Expression of c-onc genes: c-fos transcripts accumulate to high levels during development of mouse placenta, yolk sac and amnion. EMBO J. 1983;2(5):679-684.

    Not in our library10.1002/j.1460-2075.1983.tb01484.x (opens in a new tab)

21. 21.

    O'Brien S. J., Nash W. G., Goodwin J. L., Lowy D. R., Chang E. H. Dispersion of the ras family of transforming genes to four different chromosomes in man. Nature. 1983;302(5911):839-842.

    Not in our library10.1038/302839a0 (opens in a new tab)

22. 22.

    Pritchett C. J., Senior P. V., Sunter J. P., Watson A. J., Appleton D. R., Wilson R. G. Human colorectal tumours in short-term organ culture. A stathmokinetic study. Cell Tissue Kinet. 1982;15(5):555-564.

    Not in our library10.1111/j.1365-2184.1982.tb01577.x (opens in a new tab)

23. 23.

    Pulciani S., Santos E., Lauver A. V., Long L. K., Aaronson S. A., Barbacid M. Oncogenes in solid human tumours. Nature. 1982;300(5892):539-542.

    Not in our library10.1038/300539a0 (opens in a new tab)

24. 24.

    Rigby P. W., Dieckmann M., Rhodes C., Berg P. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. J Mol Biol. 1977;113(1):237-251.

    Not in our library10.1016/0022-2836(77)90052-3 (opens in a new tab)

25. 25.

    Rognum T. O., Brandtzaeg P. How reliable, in terms of oncogenic development, are functional markers of colorectal cancer? Lancet. 1983;1(8318):239-239.

    Not in our library10.1016/s0140-6736(83)92612-0 (opens in a new tab)

26. 26.

    Santos E., Tronick S. R., Aaronson S. A., Pulciani S., Barbacid M. T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes. Nature. 1982;298(5872):343-347.

    Not in our library10.1038/298343a0 (opens in a new tab)

27. 27.

    Schwab M., Alitalo K., Varmus H. E., Bishop J. M., George D. A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells. Nature. 1983;303(5917):497-501.

    Not in our library10.1038/303497a0 (opens in a new tab)

28. 28.

    Shimizu K., Birnbaum D., Ruley M. A., Fasano O., Suard Y., Edlund L., Taparowsky E., Goldfarb M., Wigler M. Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1. Nature. 1983;304(5926):497-500.

    Not in our library10.1038/304497a0 (opens in a new tab)

29. 29.

    Spandidos D. A. Cellular oncogenes, mutations and cancer. Anticancer Res. 1983;3(2):121-125.

    Not in our library

30. 30.

    Spandidos D. A., Paul J. Transfer of human globin genes to erythroleukemic mouse cells. EMBO J. 1982;1(1):15-20.

    Not in our library10.1002/j.1460-2075.1982.tb01117.x (opens in a new tab)

31. 31.

    Sunter J. P., Hull D. L., Appleton D. R., Watson A. J. Cell proliferation of colonic neoplasms in dimethylhydrazine-treated rats. Br J Cancer. 1980;42(1):95-102.

    Not in our library10.1038/bjc.1980.207 (opens in a new tab)

32. 32.

    Wahl G. M., Stern M., Stark G. R. Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. Proc Natl Acad Sci U S A. 1979;76(8):3683-3687.

    Not in our library10.1073/pnas.76.8.3683 (opens in a new tab)

33. 33.

    Westin E. H., Gallo R. C., Arya S. K., Eva A., Souza L. M., Baluda M. A., Aaronson S. A., Wong-Staal F. Differential expression of the amv gene in human hematopoietic cells. Proc Natl Acad Sci U S A. 1982;79(7):2194-2198.

    Not in our library10.1073/pnas.79.7.2194 (opens in a new tab)

34. 34.

    Westin E. H., Wong-Staal F., Gelmann E. P., Dalla-Favera R., Papas T. S., Lautenberger J. A., Eva A., Reddy E. P., Tronick S. R., Aaronson S. A. Expression of cellular homologues of retroviral onc genes in human hematopoietic cells. Proc Natl Acad Sci U S A. 1982;79(8):2490-2494.

    Not in our library10.1073/pnas.79.8.2490 (opens in a new tab)

• Rodent fibroblast tumours expressing human myc and ras genes: growth, metastasis and endogenous oncogene expression · 1987

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.