Mass and number of fibres in the pathogenesis of asbestos-related lung disease in rats

Five groups of rats were treated by inhalation for 12 months, with the U.I.C.C. preparations of the 3 main commercially used asbestos types, chrysotile, crocidolite and amosite. The experiment was designed so that the effects of both fibre mass and fibre number could be examined. The results indicated that chrysotile dust caused far more lung fibrosis than either amphibole type even when the fibre numbers in the dust clouds were similar. All malignant pulmonary neoplasms found during this study occurred in animals treated with chrysotile. The fibre-number calculations used for the generation of dust clouds were evaluated using the parameters recommended by the Health and Safety Executive in 1976, by which all fibres over 5 microgram long are counted using a phase-contrast light microscopy. When fibre-length distributions were calculated using a scanning electron microscope, however, it was found that the chrysotile clouds used in this study contained many more fibres over 20 microgram long than either of the amphibole clouds. The results, therefore, support previous suggestions that long asbestos fibres are more dangerous than short. They also indicate that neither a single mass standard, nor the present fibre-number standards are satisfactory.

Abstract licence: CC BY

1. 1.

   Beckett S. T. The evaluation of airborne asbestos fibres using a scanning electron microscope. Ann Occup Hyg. 1973;16(4):405-408.

   Not in our library10.1093/annhyg/16.4.405 (opens in a new tab)

2. 2.

   Beckett S. T. The generation and evaluation of UICC asbestos clouds in animal exposure chambers. Ann Occup Hyg. 1975;18(3):187-198.

   Not in our library10.1093/annhyg/18.3.187 (opens in a new tab)

3. 3.

   Davis J. M. Histogenesis and fine structure of peritoneal tumors produced in animals by injections of asbestos. J Natl Cancer Inst. 1974;52(6):1823-1837.

   Not in our library10.1093/jnci/52.6.1823 (opens in a new tab)

4. 4.

   Gross P., De Treville R. T. Experimental asbestosis. Studies on the progressiveness of the pulmonary fibrosis caused by chrysotile dust. Arch Environ Health. 1967;15(5):638-649.

   Not in our library10.1080/00039896.1967.10664980 (opens in a new tab)

5. 5.

   Holt P. F., Mills J., Young D. K. Experimental asbestosis with four types of fibers: importance of small particles. Ann N Y Acad Sci. 1965;132(1):87-97.

   Not in our library10.1111/j.1749-6632.1965.tb41092.x (opens in a new tab)

6. 6.

   Jacobsen M., Rae S., Walton W. H., Rogan J. M. New dust standards for British coal mines. Nature. 1970;227(5257):445-447.

   Not in our library10.1038/227445a0 (opens in a new tab)

7. 7.

   Klosterkötter W., Robock K. 1975 Yant Memorial Lecture New aspects on dust and pneumoconiosis research. Am Ind Hyg Assoc J. 1975;36(9):659-668.

   Not in our library10.1080/0002889758507312 (opens in a new tab)

8. 8.

   Maroudas N. G., O'Neill C. H., Stanton M. F. Fibroblast anchorage in carcinogenesis by fibres. Lancet. 1973;1(7807):807-809.

   Not in our library10.1016/s0140-6736(73)90604-1 (opens in a new tab)

9. 9.

   Reeves A. L., Puro H. E., Smith R. G. Inhalation carcinogenesis from various forms of asbestos. Environ Res. 1974;8(2):178-202.

   Not in our library10.1016/0013-9351(74)90050-4 (opens in a new tab)

10. 10.

    Stanton M. F., Laynard M., Tegeris A., Miller E., May M., Kent E. Carcinogenicity of fibrous glass: pleural response in the rat in relation to fiber dimension. J Natl Cancer Inst. 1977;58(3):587-603.

    Not in our library10.1093/jnci/58.3.587 (opens in a new tab)

11. 11.

    Stell P. M., McGill T. Asbestos and cancer of head and neck. Lancet. 1973;1(7804):678-678.

    Not in our library10.1016/s0140-6736(73)92256-3 (opens in a new tab)

12. 12.

    Timbrell V., Hyett A. W., Skidmore J. W. A simple dispenser for generating dust clouds from standard reference samples of asbestos. Ann Occup Hyg. 1968;11(4):273-281.

    Not in our library10.1093/annhyg/11.4.273 (opens in a new tab)

13. 13.

    The Effects of the Inhalation of Asbestos in Rats · 1974

14. 14.

    Wagner J. C., Skidmore J. W. Asbestos dust deposition and retention in rats. Ann N Y Acad Sci. 1965;132(1):77-86.

    Not in our library10.1111/j.1749-6632.1965.tb41091.x (opens in a new tab)

• Molecular engineering of a fluorescent bioprobe for sensitive and selective detection of amphibole asbestos. · 2013

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• Mesothelioma mortality in asbestos workers: Implications for models of carcinogenesis and risk assessment · 1982

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