The hippocampus: A manifesto for change.

Abstract

We currently lack a unified and mechanistic account of how the hippocampus supports a range of disparate cognitive functions that includes episodic memory, imagining the future, and spatial navigation. Here, we argue that in order to leverage this long-standing issue, traditional notions regarding the architecture of memory should be eschewed. Instead, we invoke the idea that scenes are central to hippocampal information processing. This view is motivated by mounting evidence that the hippocampus is constantly constructing spatially coherent scenes, automatically anticipating and synthesizing representations of the world beyond the immediate sensorium. By characterizing the precise relationship between scenes and the hippocampus, we believe a theoretically enriched understanding of its fundamental role and its breakdown in pathology can emerge.

Shown for reading. Its publisher allows quoting it, not republishing it.

References 70

1. 1.

   Addis D. R., Pan L., Vu M. A., Laiser N., & Schacter D. L. (2009 ). Constructive episodic simulation of the future and the past: Distinct subsystems of a core brain network mediate imagining and remembering. Neuropsychologia, 47, 2222–2238

   Not in our library10.1016/j.neuropsychologia.2008.10.026

2. 2.

   Addis D. R., Wong A. T., & Schacter D. L. (2007 ). Remembering the past and imagining the future: Common and distinct neural substrates during event construction and elaboration. Neuropsychologia, 45, 1363–1377

   Not in our library10.1016/j.neuropsychologia.2006.10.016

3. 3.

   Andelman F., Hoofien D., Goldberg I., Aizenstein O., & Neufeld M. Y. (2010 ). Bilateral hippocampal lesion and a selective impairment of the ability for mental time travel. Neurocase, 16, 426–435

   Not in our library10.1080/13554791003623318

4. 4.

   Andrews-Hanna J. R., Reidler J. S., Sepulcre J., Poulin R., & Buckner R. L. (2010 ). Functional-anatomic fractionation of the brain’s default network. Neuron, 65, 550–562

   Not in our library10.1016/j.neuron.2010.02.005

5. 5.
   Retrosplenial Cortex Codes for Permanent Landmarks · 2012

   No notice
6. 6.

   Barense M. D., Groen I. I., Lee A. C., Yeung L-K., Brady S. M., Gregori M.,...Henson R. N. A. (2012 ). Intact memory for irrelevant information impairs perception in amnesia. Neuron, 75, 157–167

   Not in our library10.1016/j.neuron.2012.05.014

7. 7.

   Barense M. D., Henson R. N., Lee A. C., & Graham K. S. (2010 ). Medial temporal lobe activity during complex discrimination of faces, objects, and scenes: Effects of viewpoint. Hippocampus, 20, 389–401

   Not in our library10.1002/hipo.20641

8. 8.

   Barry C., Lever C., Hayman R., Hartley T., Burton S., O’Keefe J.,...Burgess N. (2006 ). The boundary vector cell model of place cell firing and spatial memory. Reviews in the Neurosciences, 17, 71–97

   Not in our library10.1515/revneuro.2006.17.1-2.71

9. 9.

   Bird C. M., Bisby J. A., & Burgess N. (2012 ). The hippocampus and spatial constraints on mental imagery. Frontiers in Human Neuroscience, 6, article

   Not in our library10.3389/fnhum.2012.00142

10. 10.

    Bird C. M., Capponi C., King J. A., Doeller C. F., & Burgess N. (2010 ). Establishing the boundaries: The hippocampal contribution to imagining scenes. Journal of Neuroscience, 30, 11688–11695

    Not in our library10.1523/jneurosci.0723-10.2010

11. 11.

    Buckner R. L., & Carroll D. C. (2007 ). Self-projection and the brain. Trends in Cognitive Sciences, 11, 49–57

    Not in our library10.1016/j.tics.2006.11.004

12. 12.

    Burgess N., Maguire E. A., & O’Keefe J. (2002 ). The human hippocampus and spatial and episodic memory. Neuron, 35, 625–641

    Not in our library10.1016/s0896-6273(02)00830-9

13. 13.

    Chadwick M. J., Mullally S. L., & Maguire E. A. (in press). The hippocampus extrapolates beyond the view in scenes: An fMRI study of boundary extension. Cortex. Available online

    Not in our library10.1016/j.cortex.2012.11.010

14. 14.

    Cohen N. J., & Eichenbaum H. (1993 ). Memory, amnesia and the hippocampal system. Cambridge, MA: MIT Press

    Not in our library

15. 15.

    Dragoi G., & Tonegawa S. (2011 ). Preplay of future place cell sequences by hippocampal cellular assemblies. Nature, 469, 397–401

    Not in our library10.1038/nature09633

16. 16.

    Eichenbaum H., & Cohen N. J. (2001 ). From conditioning to conscious recollection: Memory systems of the brain. New York, NY: Oxford University Press

    Not in our library

17. 17.

    Epstein R. A. (2008 ). Parahippocampal and retrosplenial contributions to human spatial navigation. Trends in Cognitive Sciences, 12, 388–396

    Not in our library10.1016/j.tics.2008.07.004

18. 18.

    Epstein R. A. (2011 ). Cognitive neuroscience: Scene layout from vision and touch. Current Biology, 21, R437–R438

    Not in our library10.1016/j.cub.2011.04.037

19. 19.

    Friston K. (2010 ). The free-energy principle: A unified brain theory?Nature Reviews Neuroscience, 11, 127–138

    Not in our library10.1038/nrn2787

20. 20.

    Gaffan D. (2001 ). What is a memory system? Horel’s critique revisited. Behavioural Brain Research, 127, 5–11

    Not in our library10.1016/s0166-4328(01)00360-6

21. 21.

    Gaffan D. (2002 ). Against memory systems. Philosophical Transactions of the Royal Society London Series B, Biological Sciences, 357, 1111–1121

    Not in our library10.1098/rstb.2002.1110

22. 22.

    Gottesman C. V., & Intraub H. (2002 ). Surface construal and the mental representation of scenes. Journal of Experimental Psychology: Human Perception and Performance, 28, 589–599

    Not in our library10.1037/0096-1523.28.3.589

23. 23.

    Graham K. S., Barense M. D., & Lee A. C. (2010 ). Going beyond LTM in the MTL: A synthesis of neuropsychological and neuroimaging findings on the role of the medial temporal lobe in memory and perception. Neuropsychologia, 48, 831–853

    Not in our library10.1016/j.neuropsychologia.2010.01.001

24. 24.

    Hannula D. E., & Greene A. J. (2012 ). The hippocampus reevaluated in unconscious learning and memory: At a tipping point?Frontiers in Human Neuroscience, 6, article

    Not in our library10.3389/fnhum.2012.00080

25. 25.

    Hassabis D., Kumaran D., & Maguire E. A. (2007 ). Using imagination to understand the neural basis of episodic memory. Journal of Neuroscience, 27, 14365–14374

    Not in our library10.1523/jneurosci.4549-07.2007

26. 26.

    Hassabis D., Kumaran D., Vann S. D., & Maguire E. A. (2007 ). Patients with hippocampal amnesia cannot imagine new experiences. Proceedings of the National Academy of Sciences of the United States of America, 104, 1726–1731

    Not in our library10.1073/pnas.0610561104

27. 27.

    Hassabis D., & Maguire E. A. (2007 ). Deconstructing episodic memory with construction. Trends in Cognitive Sciences, 11, 299–306

    Not in our library10.1016/j.tics.2007.05.001

28. 28.

    Hassabis D., & Maguire E. A. (2009 ). The construction system of the brain. Philosophical Transactions of the Royal Society London Series B, Biological Sciences, 364, 1263–1271

    Not in our library10.1098/rstb.2008.0296

29. 29.

    Hayman R. M., Donnett J. G., & Jeffery K. J. (2008 ). The fuzzy-boundary arena—A method for constraining an animal’s range in spatial experiments without using walls. Journal of Neuroscience Methods, 167, 184–190

    Not in our library10.1016/j.jneumeth.2007.08.014

30. 30.

    Horel J. A. (1978 ). The neuroanatomy of amnesia: A critique of the hippocampal memory hypothesis. Brain, 101, 403–445

    Not in our library10.1093/brain/101.3.403

31. 31.

    Intraub H., & Dickinson C. A. (2008 ). False memory 1/20th of a second later: What the early onset of boundary extension reveals about perception. Psychological Science, 19, 1007–1014

    Not in our library10.1111/j.1467-9280.2008.02192.x

32. 32.

    Intraub H., & Richardson M. (1989 ). Wide-angle memories of close-up scenes. Journal of Experimental Psychology: Learning, Memory, and Cognition, 15, 179–187

    Not in our library10.1037/0278-7393.15.2.179

33. 33.

    Jones M. K. (1974 ). Imagery as a mnemonic aid after left temporal lobectomy: Contrast between material-specific and generalized memory disorders. Neuropsychologia, 12, 21–30

    Not in our library10.1016/0028-3932(74)90023-2

34. 34.

    Killian N. J., Jutras M. J., & Buffalo E. A. (2012 ). A map of visual space in the primate entorhinal cortex. Nature, 491, 761–764

    Not in our library10.1038/nature11587

35. 35.

    Klein S. B., Loftus J., & Kihlstrom J. F. (2002 ). Memory and temporal experience: The effects of episodic memory loss on an amnesic patient’s ability to remember the past and imagine the future. Social Cognition, 20, 353–379

    Not in our library10.1521/soco.20.5.353.21125

36. 36.

    Konkel A., & Cohen N. J. (2009 ). Relational memory and the hippocampus: Representations and methods. Frontiers in Neuroscience, 3, 166–174

    Not in our library10.3389/neuro.01.023.2009

37. 37.

    Lee A. C., Brodersen K. H., & Rudebeck S. R. (2013 ). Disentangling spatial perception and spatial memory in the hippocampus: A univariate and multivariate pattern analysis fMRI study. Journal of Cognitive Neuroscience, 25, 534–546

    Not in our library10.1162/jocn_a_00301

38. 38.

    Lee A. C., Buckley M. J., Gaffan D., Emery T., Hodges J. R., & Graham K. S. (2006 ). Differentiating the roles of the hippocampus and perirhinal cortex in processes beyond long-term declarative memory: A double dissociation in dementia. Journal of Neuroscience, 26, 5198–5203

    Not in our library10.1523/jneurosci.3157-05.2006

39. 39.

    Lee A. C. H., Buckley M. J., Pegman S. J., Spiers H., Scahill V. L., Gaffan D.,...Graham K. S. (2005 ). Specialization in the medial temporal lobe for processing of objects and scenes. Hippocampus, 15, 782–797

    Not in our library10.1002/hipo.20101

40. 40.

    Lee A. C. H., Bussey T. J., Murray E. A., Saksida L. M., Epstein R. A., Kapur N.,...Graham K. S. (2005 ). Perceptual deficits in amnesia: Challenging the medial temporal lobe “mnemonic” view. Neuropsychologia, 43, 1–11

    Not in our library10.1016/j.neuropsychologia.2004.07.017

Cited by papers we hold 8

• Comparing and Contrasting the Cognitive Effects of Hippocampal and Ventromedial Prefrontal Cortex Damage: A Review of Human Lesion Studies · 2018
  No notice
• Cognitive Neuroscience of Human Counterfactual Reasoning · 2015
  Not checked
• Solving the detour problem in navigation: A model of prefrontal and hippocampal interactions · 2015
  Not checked
• Constructing, Perceiving, and Maintaining Scenes: Hippocampal Activity and Connectivity · 2014
  No notice
• Contributions of cortical feedback to sensory processing in primary visual cortex · 2014
  Not checked
• Decoding Sound and Imagery Content in Early Visual Cortex · 2014
  No notice
• The role of the hippocampus in flexible cognition and social behavior · 2014
  No notice
• Memory, Imagination, and Predicting the Future · 2013
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.