Strategies to prevent central line-associated bloodstream infections in acute-care hospitals: 2022 Update

1Previously published guidelines provide comprehensive recommendations for detecting and preventing healthcare-associated infections (HAIs). The intent of this document is to highlight practical recommendations in a concise format designed to assist acute-care hospitals in implementing and prioritizing their central line-associated bloodstream infection (CLABSI) prevention efforts. This document updates the Strategies to Prevent Central Line-Associated Bloodstream Infections in Acute-Care Hospitals published in 2014. This expert guidance document is sponsored by the Society for Healthcare Epidemiology of America (SHEA). It is the product of a collaborative effort led by SHEA, the Infectious Diseases Society of America (IDSA), the Association for Professionals in Infection Control and Epidemiology (APIC), the American Hospital Association (AHA), and The Joint Commission, with major contributions from representatives of a number of organizations and societies with content expertise.

2This section lists major changes from the Strategies to Prevent Central Line-Associated Bloodstream Infections in Acute-Care Hospitals: 2014 Update, including recommendations that have been added, removed, or altered. Recommendations are categorized as essential practices that should be adopted by all acute-care hospitals (in 2014 these were “basic practices,” renamed to highlight their importance as foundational for hospitals’ HAI prevention programs) or additional approaches that can be considered for use in locations and/or populations within hospitals when CLABSIs are not controlled after implementation of essential practices (in 2014 these were “special approaches”). See Table 1 for a complete summary of the recommendations contained in this document.

3The subclavian vein is considered the preferable site for central venous catheter (CVC) insertion in the intensive care setting to reduce infectious complications. Previously, the primary recommendation was to avoid the femoral vein for access. Although this remains valid, it has been replaced by a positively formulated recommendation regarding the subclavian site.The recommendation to use ultrasound guidance for catheter insertion is backed by better evidence than was available previously; however, the procedure itself may jeopardize the strict observation of sterile technique.The use of chlorhexidine-containing dressings is now considered an “essential practice”; in the past, it was listed under special approaches that should only be employed if CLABSI rates remain high despite the implementation of basic practices.Routine replacement of administration sets not used for blood, blood products, or lipid formulations can be performed at intervals of up to 7 days. Previously, this interval was no longer than 4 days.

4The subclavian vein is considered the preferable site for central venous catheter (CVC) insertion in the intensive care setting to reduce infectious complications. Previously, the primary recommendation was to avoid the femoral vein for access. Although this remains valid, it has been replaced by a positively formulated recommendation regarding the subclavian site.

5The recommendation to use ultrasound guidance for catheter insertion is backed by better evidence than was available previously; however, the procedure itself may jeopardize the strict observation of sterile technique.

6The use of chlorhexidine-containing dressings is now considered an “essential practice”; in the past, it was listed under special approaches that should only be employed if CLABSI rates remain high despite the implementation of basic practices.

7Routine replacement of administration sets not used for blood, blood products, or lipid formulations can be performed at intervals of up to 7 days. Previously, this interval was no longer than 4 days.

8Antimicrobial ointment for the catheter site, which is geared toward the population of hemodialysis patients, has been moved to “additional practices” given the focus on a specific population.Despite currently being supported by high-level evidence, antiseptic-containing caps remain an “additional practice” because they are not considered superior to the manual disinfection, an essential practice.The importance of infusion teams has been highlighted by listing it under “additional practices” (previously considered unresolved).Sutureless securement of catheters was not discussed in the previous version of this section.

9Antimicrobial ointment for the catheter site, which is geared toward the population of hemodialysis patients, has been moved to “additional practices” given the focus on a specific population.

10Despite currently being supported by high-level evidence, antiseptic-containing caps remain an “additional practice” because they are not considered superior to the manual disinfection, an essential practice.

11The importance of infusion teams has been highlighted by listing it under “additional practices” (previously considered unresolved).

12Sutureless securement of catheters was not discussed in the previous version of this section.

13This document was developed following the process outlined in the Handbook for SHEA-Sponsored Guidelines and Expert Guidance Documents. No guideline or expert guidance document can anticipate all clinical situations, and this document is not meant to be a substitute for individual clinical judgment by qualified professionals.

14This document is based on a synthesis of evidence, theoretical rationale, current practices, practical considerations, writing-group consensus, and consideration of potential harm, where applicable. A summary list of recommendations is provided along with their relevant rationales (see Table 1).

15SHEA recruited 3 subject-matter experts in the prevention of CLABSI to lead the panel of members representing the Compendium partnering organizations: SHEA, the Infectious Diseases Society of America (IDSA), the Association for Professionals in Infection Control and Epidemiology (APIC), the American Hospital Association (AHA), and The Joint Commission, as well as representation by the Centers for Disease Control and Prevention (CDC).

16SHEA utilized a consultant medical librarian, who worked with each panel to develop a comprehensive search strategy for PubMed and Embase (January 2012–July 2019; updated to August 2021). Articles’ abstracts were reviewed by panel members in a double-blind fashion using the abstract management software, Covidence (Melbourne, Australia), and subsequently reviewed as full text. The Compendium Lead Authors group voted to update the literature findings, and the librarian reran the search to update it to August 2021. Panel members reviewed the abstracts of these articles via Covidence and incorporated relevant references.

17Recommendations resulting from this literature review process were classified based on the quality of evidence and the balance between desirable and potential for undesirable effects of various interventions (see Table 2). Panel members met via video conference to discuss literature findings; recommendations; quality of evidence for these recommendations; and classification as essential practices, additional approaches, or unresolved issues. Panel members reviewed and approved the document and its recommendations.

18The Compendium Expert Panel, made up of members with broad healthcare epidemiology and infection prevention expertise, reviewed the draft manuscript after consensus had been reached by writing panel members.

19Following review and approval by the Expert Panel, the 5 partnering organizations, stakeholder organizations, and the CDC reviewed the document. Prior to dissemination, the guidance document was reviewed and approved by the SHEA Guidelines Committee, the IDSA Standards and Practice Guidelines Committee, and the Boards of SHEA, IDSA, APIC, AHA, and The Joint Commission.

20All panel members complied with SHEA and IDSA policies on conflict-of-interest disclosure.

21Increased length of hospital stay – Increased cost. The adjusted variable costs for patients with CLABSI were $32,000 (2010 US dollars) higher on average than for patients without CLABSI Increased morbidity and mortality

22Increased length of hospital stay –

23Increased cost. The adjusted variable costs for patients with CLABSI were $32,000 (2010 US dollars) higher on average than for patients without CLABSI

24Increased morbidity and mortality

25Patients at risk for CLABSI in acute-care facilities are those with a CVC in place:Intensive care unit (ICU) population: The risk of CLABSI in ICU patients is high. Reasons for this include the frequent insertion of multiple catheters,; the use of specific types of catheters that are almost exclusively inserted in ICU patients and associated with substantial risk (eg, pulmonary artery catheters with catheter introducers); and the fact that catheters are frequently placed in emergency circumstances, repeatedly accessed each day, and often needed for extended periods., Non-ICU population: Although the primary focus of attention over the last 20 years has been the ICU setting, most CLABSIs occur in hospital units outside the ICU or in outpatients. – Infection prevention and control efforts should include other vulnerable populations such as patients receiving hemodialysis through catheters, intraoperative patients, and oncology patients. In addition to CVCs, short-term peripheral catheters, peripherally inserted central venous catheters (PICCs), midline catheters, and peripheral arterial catheters also carry a risk of infection. Independent risk factors for CLABSI (in at least 2 published studies) – Prolonged hospitalization before catheterizationProlonged duration of catheterizationHeavy microbial colonization at insertion siteHeavy microbial colonization of the catheter hubMultilumen cathetersConcurrent cathetersNeutropeniaBody mass index (BMI) >40Prematurity (ie, early gestational age)Reduced nurse-to-patient ratio in the ICUParenteral nutritionSubstandard catheter care (eg, excessive manipulation of the catheter)Transfusion of blood products (in children)

26Patients at risk for CLABSI in acute-care facilities are those with a CVC in place:Intensive care unit (ICU) population: The risk of CLABSI in ICU patients is high. Reasons for this include the frequent insertion of multiple catheters,; the use of specific types of catheters that are almost exclusively inserted in ICU patients and associated with substantial risk (eg, pulmonary artery catheters with catheter introducers); and the fact that catheters are frequently placed in emergency circumstances, repeatedly accessed each day, and often needed for extended periods., Non-ICU population: Although the primary focus of attention over the last 20 years has been the ICU setting, most CLABSIs occur in hospital units outside the ICU or in outpatients. –

27Intensive care unit (ICU) population: The risk of CLABSI in ICU patients is high. Reasons for this include the frequent insertion of multiple catheters,; the use of specific types of catheters that are almost exclusively inserted in ICU patients and associated with substantial risk (eg, pulmonary artery catheters with catheter introducers); and the fact that catheters are frequently placed in emergency circumstances, repeatedly accessed each day, and often needed for extended periods.,

28Non-ICU population: Although the primary focus of attention over the last 20 years has been the ICU setting, most CLABSIs occur in hospital units outside the ICU or in outpatients. –

29Infection prevention and control efforts should include other vulnerable populations such as patients receiving hemodialysis through catheters, intraoperative patients, and oncology patients.

30In addition to CVCs, short-term peripheral catheters, peripherally inserted central venous catheters (PICCs), midline catheters, and peripheral arterial catheters also carry a risk of infection.

31Independent risk factors for CLABSI (in at least 2 published studies) – Prolonged hospitalization before catheterizationProlonged duration of catheterizationHeavy microbial colonization at insertion siteHeavy microbial colonization of the catheter hubMultilumen cathetersConcurrent cathetersNeutropeniaBody mass index (BMI) >40Prematurity (ie, early gestational age)Reduced nurse-to-patient ratio in the ICUParenteral nutritionSubstandard catheter care (eg, excessive manipulation of the catheter)Transfusion of blood products (in children)

32Prolonged hospitalization before catheterization

33Prolonged duration of catheterization

34Heavy microbial colonization at insertion site

35Heavy microbial colonization of the catheter hub

36Multilumen catheters

37Concurrent catheters

38Neutropenia

39Body mass index (BMI) >40

40Prematurity (ie, early gestational age)

41Reduced nurse-to-patient ratio in the ICU

42Parenteral nutrition

43Substandard catheter care (eg, excessive manipulation of the catheter)

44Transfusion of blood products (in children)

45Use consistent surveillance methods and definitions to allow comparison to benchmark data.Refer to the National Healthcare Safety Network (NHSN) Patient Safety Component Manual for information on the appropriate surveillance methodology, including information about blood specimen collection and surveillance definitions of CLABSIs. The relevant chapter of the manual is “Chapter 4: Bloodstream Infection Event (Central Line-Associated Bloodstream Infection and Non-Central Line-Associated Bloodstream Infection).” Recent data suggest that interrater reliability using NHSN definitions is lower than expected. – This may also affect the reliability of public reporting.The NHSN surveillance definition for CLABSI is different than the clinical definition for catheter-related bloodstream infection (CRBSI). The latter is subject to various factors (eg, laboratory capabilities, catheter removal, and submitting the catheter tip for culture). The evidence presented here includes studies that used either CLABSI or CRBSI as an outcome measure and the lesser accuracy of CLABSI may impact the validity of the evidence.

46Use consistent surveillance methods and definitions to allow comparison to benchmark data.

47Refer to the National Healthcare Safety Network (NHSN) Patient Safety Component Manual for information on the appropriate surveillance methodology, including information about blood specimen collection and surveillance definitions of CLABSIs. The relevant chapter of the manual is “Chapter 4: Bloodstream Infection Event (Central Line-Associated Bloodstream Infection and Non-Central Line-Associated Bloodstream Infection).” Recent data suggest that interrater reliability using NHSN definitions is lower than expected. – This may also affect the reliability of public reporting.The NHSN surveillance definition for CLABSI is different than the clinical definition for catheter-related bloodstream infection (CRBSI). The latter is subject to various factors (eg, laboratory capabilities, catheter removal, and submitting the catheter tip for culture). The evidence presented here includes studies that used either CLABSI or CRBSI as an outcome measure and the lesser accuracy of CLABSI may impact the validity of the evidence.

48Recent data suggest that interrater reliability using NHSN definitions is lower than expected. – This may also affect the reliability of public reporting.

49The NHSN surveillance definition for CLABSI is different than the clinical definition for catheter-related bloodstream infection (CRBSI). The latter is subject to various factors (eg, laboratory capabilities, catheter removal, and submitting the catheter tip for culture). The evidence presented here includes studies that used either CLABSI or CRBSI as an outcome measure and the lesser accuracy of CLABSI may impact the validity of the evidence.

50Several governmental, public health, and professional organizations have published evidence-based guidelines and/or implementation aids regarding the prevention of CLABSI including the following:Healthcare Infection Control Practices Advisory Committee (HICPAC), Centers for Disease Control and Prevention (CDC), Institute for Healthcare Improvement (IHI) Agency for Healthcare Research and Quality, Making Health Care Safer American Pediatric Surgical Association, Outcomes and Clinical Trials Committee The Joint Commission APIC, Implementation Guide to Preventing Central Line-Associated Bloodstream Infections Infusion Nurses Society, Infusion Nursing Standards of Practice The recommendations in this document focus on CVCs unless noted otherwise. These recommendations:Are not stratified based on the type of catheter (eg, tunneled, implanted, cuffed, non-cuffed catheter, dialysis catheter).May not be applicable in their entirety for prevention of bloodstream infections with other intravascular devices.

51Several governmental, public health, and professional organizations have published evidence-based guidelines and/or implementation aids regarding the prevention of CLABSI including the following:Healthcare Infection Control Practices Advisory Committee (HICPAC), Centers for Disease Control and Prevention (CDC), Institute for Healthcare Improvement (IHI) Agency for Healthcare Research and Quality, Making Health Care Safer American Pediatric Surgical Association, Outcomes and Clinical Trials Committee The Joint Commission APIC, Implementation Guide to Preventing Central Line-Associated Bloodstream Infections Infusion Nurses Society, Infusion Nursing Standards of Practice

52Healthcare Infection Control Practices Advisory Committee (HICPAC), Centers for Disease Control and Prevention (CDC),

53Institute for Healthcare Improvement (IHI)

54Agency for Healthcare Research and Quality, Making Health Care Safer

55American Pediatric Surgical Association, Outcomes and Clinical Trials Committee

56The Joint Commission

57APIC, Implementation Guide to Preventing Central Line-Associated Bloodstream Infections

58Infusion Nurses Society, Infusion Nursing Standards of Practice

59The recommendations in this document focus on CVCs unless noted otherwise. These recommendations:Are not stratified based on the type of catheter (eg, tunneled, implanted, cuffed, non-cuffed catheter, dialysis catheter).May not be applicable in their entirety for prevention of bloodstream infections with other intravascular devices.

60Are not stratified based on the type of catheter (eg, tunneled, implanted, cuffed, non-cuffed catheter, dialysis catheter).

61May not be applicable in their entirety for prevention of bloodstream infections with other intravascular devices.

62Facilities undertaking CLABSI interventions should have the following elements in place:An adequately staffed infection prevention and control program responsible for identifying patients who meet the surveillance definition for CLABSI.Infection prevention staff and, preferably, information technology support to collect and calculate catheter days as a denominator when computing rates of CLABSI and patient days to allow calculation of CVC utilization. Catheter days from information systems should be validated against a manual method, with a margin of error no greater than ±5%. – Resources to provide appropriate education and training.Adequate laboratory support for timely processing of specimens and reporting of results, as specified by the supervisor of the surveillance program.

63An adequately staffed infection prevention and control program responsible for identifying patients who meet the surveillance definition for CLABSI.

64Infection prevention staff and, preferably, information technology support to collect and calculate catheter days as a denominator when computing rates of CLABSI and patient days to allow calculation of CVC utilization. Catheter days from information systems should be validated against a manual method, with a margin of error no greater than ±5%. –

65Resources to provide appropriate education and training.

66Adequate laboratory support for timely processing of specimens and reporting of results, as specified by the supervisor of the surveillance program.

67Recommendations are categorized as either (1) essential practices that should be adopted by all acute-care hospitals or (2) additional approaches that can be considered in locations and/or populations within hospitals when CLABSIs are not controlled by use of essential practices. Essential practices include recommendations in which the potential to affect CLABSI risk clearly outweighs the potential for undesirable effects. Additional approaches include recommendations in which the intervention is likely to reduce CLABSI risk but there is concern about the risks for undesirable outcomes, recommendations for which the quality of evidence is low, recommendations in which cost-to-benefit ratio may be high, or recommendations in which evidence supports the impact of the intervention in select settings (eg, during outbreaks) or for select patient populations. Hospitals can prioritize their efforts by initially focusing on implementation of the prevention strategies listed as essential practices. If CLABSI surveillance or other risk assessments suggest ongoing opportunities for improvement, hospitals should consider adopting some or all of the prevention approaches listed as additional approaches. These can be implemented in specific locations or patient populations or can be implemented hospital-wide, depending on outcome data, risk assessment, and/or local requirements. Each infection prevention recommendation is given a quality of evidence grade (see Table 2).

68Some of the following measures have been combined into a “prevention bundle” that focuses on catheter insertion., Numerous studies have documented that use of such bundles is effective, sustainable, and cost-effective in both adults and children.,– Bundles are most likely to be successful if implemented in a previously established patient safety culture and their success depends on adherence to individual measures. However, data suggests that not all components of bundles may be necessary to achieve an effect on CLABSI rates. After catheter insertion, maintenance bundles have been proposed to ensure optimal catheter care. More data are needed to determine which components of the maintenance bundle are essential in reducing risk.,

69Provide easy access to an evidence-based list of indications for CVC use to minimize unnecessary CVC placement (Quality of Evidence: LOW) Require education and competency assessment of healthcare personnel (HCP) involved in insertion, care, and maintenance of CVCs about CLABSI prevention (Quality of Evidence: MODERATE) – Include the indications for catheter use, appropriate insertion and maintenance, the risk of CLABSI, and general infection prevention strategies.Ensure that all HCP involved in catheter insertion and maintenance complete an educational program on essential practices to prevent CLABSI before performing these duties., Periodic retraining with a competency assessment may be of benefit. Periodically assess HCP knowledge of and adherence to preventive measures.Require all HCP who insert a CVC to undergo a credentialing process (as established by the individual healthcare institution) to ensure their competency before independently inserting a CVC and aseptic technique for accessing and maintaining the CVC thereafter.Re-educate when an institution changes components of the infusion system that requires a change in practice (eg, when an institution’s change of the needleless connector requires a change in nursing practice).Use simulation training for proper catheter insertion and maintenance if available. – Bathe ICU patients >2 months of age with a chlorhexidine preparation on a daily basis (Quality of Evidence: HIGH) – In long-term acute-care hospitals (LTACHs), daily chlorhexidine bathing may also be considered as a preventive measure. The role of chlorhexidine bathing in non-ICU patients remains unclear., One cluster-randomized study found a significant reduction in device-associated bacteremia with CHG bathing in this patient population; however, some of these patients also received methicillin-resistant Staphylococcus aureus (MRSA) decolonization, making it difficult to draw firm conclusions regarding CHG bathing alone. Several studies have suggested benefit among adult hematology-oncology patients; however, a similar reduction was not observed for pediatric patients with similar conditions., Accordingly, potential benefits and risks, such as increases in resistance and cost, need to be carefully considered.The safety and efficacy of routine use of chlorhexidine bathing in infants <2 months of postnatal age remains unclear. Although life-threatening skin injuries from CHG have been reported in very young or very preterm infants, they typically occur in infants with a birthweight <1,000 g who are <7 days postnatal age, and they appear rare in older infants. – Widespread use of chlorhexidine may be associated with decreased chlorhexidine susceptibility, although the clinical relevance of this finding is not well defined.

70Provide easy access to an evidence-based list of indications for CVC use to minimize unnecessary CVC placement (Quality of Evidence: LOW)

71Require education and competency assessment of healthcare personnel (HCP) involved in insertion, care, and maintenance of CVCs about CLABSI prevention (Quality of Evidence: MODERATE) – Include the indications for catheter use, appropriate insertion and maintenance, the risk of CLABSI, and general infection prevention strategies.Ensure that all HCP involved in catheter insertion and maintenance complete an educational program on essential practices to prevent CLABSI before performing these duties., Periodic retraining with a competency assessment may be of benefit. Periodically assess HCP knowledge of and adherence to preventive measures.Require all HCP who insert a CVC to undergo a credentialing process (as established by the individual healthcare institution) to ensure their competency before independently inserting a CVC and aseptic technique for accessing and maintaining the CVC thereafter.Re-educate when an institution changes components of the infusion system that requires a change in practice (eg, when an institution’s change of the needleless connector requires a change in nursing practice).Use simulation training for proper catheter insertion and maintenance if available. –

72Include the indications for catheter use, appropriate insertion and maintenance, the risk of CLABSI, and general infection prevention strategies.

73Ensure that all HCP involved in catheter insertion and maintenance complete an educational program on essential practices to prevent CLABSI before performing these duties., Periodic retraining with a competency assessment may be of benefit.

74Periodically assess HCP knowledge of and adherence to preventive measures.

75Require all HCP who insert a CVC to undergo a credentialing process (as established by the individual healthcare institution) to ensure their competency before independently inserting a CVC and aseptic technique for accessing and maintaining the CVC thereafter.

76Re-educate when an institution changes components of the infusion system that requires a change in practice (eg, when an institution’s change of the needleless connector requires a change in nursing practice).

77Use simulation training for proper catheter insertion and maintenance if available. –

78Bathe ICU patients >2 months of age with a chlorhexidine preparation on a daily basis (Quality of Evidence: HIGH) – In long-term acute-care hospitals (LTACHs), daily chlorhexidine bathing may also be considered as a preventive measure. The role of chlorhexidine bathing in non-ICU patients remains unclear., One cluster-randomized study found a significant reduction in device-associated bacteremia with CHG bathing in this patient population; however, some of these patients also received methicillin-resistant Staphylococcus aureus (MRSA) decolonization, making it difficult to draw firm conclusions regarding CHG bathing alone. Several studies have suggested benefit among adult hematology-oncology patients; however, a similar reduction was not observed for pediatric patients with similar conditions., Accordingly, potential benefits and risks, such as increases in resistance and cost, need to be carefully considered.The safety and efficacy of routine use of chlorhexidine bathing in infants <2 months of postnatal age remains unclear. Although life-threatening skin injuries from CHG have been reported in very young or very preterm infants, they typically occur in infants with a birthweight <1,000 g who are <7 days postnatal age, and they appear rare in older infants. – Widespread use of chlorhexidine may be associated with decreased chlorhexidine susceptibility, although the clinical relevance of this finding is not well defined.

79In long-term acute-care hospitals (LTACHs), daily chlorhexidine bathing may also be considered as a preventive measure.

80The role of chlorhexidine bathing in non-ICU patients remains unclear., One cluster-randomized study found a significant reduction in device-associated bacteremia with CHG bathing in this patient population; however, some of these patients also received methicillin-resistant Staphylococcus aureus (MRSA) decolonization, making it difficult to draw firm conclusions regarding CHG bathing alone. Several studies have suggested benefit among adult hematology-oncology patients; however, a similar reduction was not observed for pediatric patients with similar conditions., Accordingly, potential benefits and risks, such as increases in resistance and cost, need to be carefully considered.

81The safety and efficacy of routine use of chlorhexidine bathing in infants <2 months of postnatal age remains unclear. Although life-threatening skin injuries from CHG have been reported in very young or very preterm infants, they typically occur in infants with a birthweight <1,000 g who are <7 days postnatal age, and they appear rare in older infants. –

82Widespread use of chlorhexidine may be associated with decreased chlorhexidine susceptibility, although the clinical relevance of this finding is not well defined.

83In ICU and non-ICU settings, a facility should have a process in place, such as a checklist, to ensure adherence to infection prevention practices at the time of CVC insertion (Quality of Evidence: MODERATE) Ensure and document adherence to aseptic techniqueChecklists have been suggested to ensure optimal insertion practices. If used, the documentation should be done by someone other than the inserter.Observation of CVC insertion should be done by a nurse, physician, or other HCP who has received appropriate education (see above) to ensure that aseptic technique is maintained.HCP should be empowered to stop the procedure if breaches in aseptic technique are observed. Perform hand hygiene prior to catheter insertion or manipulation (Quality of Evidence: MODERATE) – Use an alcohol-based waterless product or soap and water.Use of gloves does not obviate hand hygiene. The subclavian site is preferred to reduce infectious complications when the catheter is placed in the ICU setting (Quality of Evidence: HIGH),,– In the non-ICU setting, the risk of infection between the different sites remains unclear. Importantly, in emergent settings, ensuring life-saving vascular access in the fastest possible way may determine the choice of access site.In children and infants, femoral vein catheterization may be considered if upper body sites are contraindicated. Tunneled femoral vein catheters, with an exit site outside the diaper area in the mid-thigh, may be safer and provide additional risk reduction., Controversy exists regarding infectious and noninfectious complications associated with different short-term CVC access sites. The risk and benefit of different insertion sites must be considered on an individual basis with regard to infectious and noninfectious complications. Among others, this applies to patients currently receiving or likely to require hemodialysis in whom the subclavian site is avoided due to risk of stenosis.Do not use peripherally inserted central venous catheters (PICCs) as a strategy to reduce the risk of CLABSI. Risk of infection with PICCs in hospitalized patients approaches that of other CVCs. However, the majority of CLABSIs due to PICCs occur in non-ICU settings. Midline catheters are increasingly being used as an alternative to CVCs for short-term vascular access, with some observational studies suggesting lower bloodstream infection risk associated with midline catheters versus PICCs and versus CVCs, respectively. Randomized controlled trials comparing the risk of bloodstream infections and other complications associated with these devices are needed. Use an all-inclusive catheter cart or kit (Quality of Evidence: MODERATE) A catheter cart or kit that contains all necessary components for aseptic catheter insertion should be available and easily accessible in all units where CVCs are inserted. Use ultrasound guidance for catheter insertion (Quality of Evidence: HIGH), Ultrasound-guided internal jugular and femoral vein catheterization reduces the risk of noninfectious complications associated with CVC placement but the use of ultrasound may lead to a breach in aseptic technique. It is unclear whether ultrasound-guided subclavian vein insertion reduces risk of infectious complications. Use maximum sterile barrier precautions during CVC insertion (Quality of Evidence: MODERATE) – Use maximum sterile barrier precautions:A mask, cap, sterile gown, and sterile gloves are to be worn by all HCP involved in the catheter insertion procedure.The patient is to be covered with a large (“full-body”) sterile drape during catheter insertion. These measures should also be followed when exchanging a catheter over a guidewire.A prospective, randomized study in surgical patients showed no additional benefit for maximum sterile barrier precautions; nevertheless, most available evidence suggests risk reduction with this intervention. Use an alcoholic chlorhexidine antiseptic for skin preparation (Quality of Evidence: HIGH),– Before catheter insertion, apply an alcoholic chlorhexidine solution containing at least 2% chlorhexidine gluconate to the insertion site.The antiseptic solution must be allowed to dry before making the skin puncture.Alcoholic chlorhexidine for skin antisepsis to prevent CLABSI in NICU patients should be used when the benefits are judged to outweigh potential risk.

84In ICU and non-ICU settings, a facility should have a process in place, such as a checklist, to ensure adherence to infection prevention practices at the time of CVC insertion (Quality of Evidence: MODERATE) Ensure and document adherence to aseptic techniqueChecklists have been suggested to ensure optimal insertion practices. If used, the documentation should be done by someone other than the inserter.Observation of CVC insertion should be done by a nurse, physician, or other HCP who has received appropriate education (see above) to ensure that aseptic technique is maintained.HCP should be empowered to stop the procedure if breaches in aseptic technique are observed.

85Ensure and document adherence to aseptic techniqueChecklists have been suggested to ensure optimal insertion practices. If used, the documentation should be done by someone other than the inserter.Observation of CVC insertion should be done by a nurse, physician, or other HCP who has received appropriate education (see above) to ensure that aseptic technique is maintained.HCP should be empowered to stop the procedure if breaches in aseptic technique are observed.

86Checklists have been suggested to ensure optimal insertion practices. If used, the documentation should be done by someone other than the inserter.

87Observation of CVC insertion should be done by a nurse, physician, or other HCP who has received appropriate education (see above) to ensure that aseptic technique is maintained.

88HCP should be empowered to stop the procedure if breaches in aseptic technique are observed.

89Perform hand hygiene prior to catheter insertion or manipulation (Quality of Evidence: MODERATE) – Use an alcohol-based waterless product or soap and water.Use of gloves does not obviate hand hygiene.

90Use an alcohol-based waterless product or soap and water.Use of gloves does not obviate hand hygiene.

91Use of gloves does not obviate hand hygiene.

92The subclavian site is preferred to reduce infectious complications when the catheter is placed in the ICU setting (Quality of Evidence: HIGH),,– In the non-ICU setting, the risk of infection between the different sites remains unclear. Importantly, in emergent settings, ensuring life-saving vascular access in the fastest possible way may determine the choice of access site.In children and infants, femoral vein catheterization may be considered if upper body sites are contraindicated. Tunneled femoral vein catheters, with an exit site outside the diaper area in the mid-thigh, may be safer and provide additional risk reduction., Controversy exists regarding infectious and noninfectious complications associated with different short-term CVC access sites. The risk and benefit of different insertion sites must be considered on an individual basis with regard to infectious and noninfectious complications. Among others, this applies to patients currently receiving or likely to require hemodialysis in whom the subclavian site is avoided due to risk of stenosis.Do not use peripherally inserted central venous catheters (PICCs) as a strategy to reduce the risk of CLABSI. Risk of infection with PICCs in hospitalized patients approaches that of other CVCs. However, the majority of CLABSIs due to PICCs occur in non-ICU settings. Midline catheters are increasingly being used as an alternative to CVCs for short-term vascular access, with some observational studies suggesting lower bloodstream infection risk associated with midline catheters versus PICCs and versus CVCs, respectively. Randomized controlled trials comparing the risk of bloodstream infections and other complications associated with these devices are needed.

93In the non-ICU setting, the risk of infection between the different sites remains unclear. Importantly, in emergent settings, ensuring life-saving vascular access in the fastest possible way may determine the choice of access site.

94In children and infants, femoral vein catheterization may be considered if upper body sites are contraindicated. Tunneled femoral vein catheters, with an exit site outside the diaper area in the mid-thigh, may be safer and provide additional risk reduction.,

95Controversy exists regarding infectious and noninfectious complications associated with different short-term CVC access sites. The risk and benefit of different insertion sites must be considered on an individual basis with regard to infectious and noninfectious complications. Among others, this applies to patients currently receiving or likely to require hemodialysis in whom the subclavian site is avoided due to risk of stenosis.

96Do not use peripherally inserted central venous catheters (PICCs) as a strategy to reduce the risk of CLABSI. Risk of infection with PICCs in hospitalized patients approaches that of other CVCs. However, the majority of CLABSIs due to PICCs occur in non-ICU settings.

97Midline catheters are increasingly being used as an alternative to CVCs for short-term vascular access, with some observational studies suggesting lower bloodstream infection risk associated with midline catheters versus PICCs and versus CVCs, respectively. Randomized controlled trials comparing the risk of bloodstream infections and other complications associated with these devices are needed.

98Use an all-inclusive catheter cart or kit (Quality of Evidence: MODERATE) A catheter cart or kit that contains all necessary components for aseptic catheter insertion should be available and easily accessible in all units where CVCs are inserted.

99A catheter cart or kit that contains all necessary components for aseptic catheter insertion should be available and easily accessible in all units where CVCs are inserted.

100Use ultrasound guidance for catheter insertion (Quality of Evidence: HIGH), Ultrasound-guided internal jugular and femoral vein catheterization reduces the risk of noninfectious complications associated with CVC placement but the use of ultrasound may lead to a breach in aseptic technique. It is unclear whether ultrasound-guided subclavian vein insertion reduces risk of infectious complications.

101Ultrasound-guided internal jugular and femoral vein catheterization reduces the risk of noninfectious complications associated with CVC placement but the use of ultrasound may lead to a breach in aseptic technique.

102It is unclear whether ultrasound-guided subclavian vein insertion reduces risk of infectious complications.

103Use maximum sterile barrier precautions during CVC insertion (Quality of Evidence: MODERATE) – Use maximum sterile barrier precautions:A mask, cap, sterile gown, and sterile gloves are to be worn by all HCP involved in the catheter insertion procedure.The patient is to be covered with a large (“full-body”) sterile drape during catheter insertion. These measures should also be followed when exchanging a catheter over a guidewire.A prospective, randomized study in surgical patients showed no additional benefit for maximum sterile barrier precautions; nevertheless, most available evidence suggests risk reduction with this intervention.

104Use maximum sterile barrier precautions:A mask, cap, sterile gown, and sterile gloves are to be worn by all HCP involved in the catheter insertion procedure.The patient is to be covered with a large (“full-body”) sterile drape during catheter insertion.

105A mask, cap, sterile gown, and sterile gloves are to be worn by all HCP involved in the catheter insertion procedure.

106The patient is to be covered with a large (“full-body”) sterile drape during catheter insertion.

107These measures should also be followed when exchanging a catheter over a guidewire.

108A prospective, randomized study in surgical patients showed no additional benefit for maximum sterile barrier precautions; nevertheless, most available evidence suggests risk reduction with this intervention.

109Use an alcoholic chlorhexidine antiseptic for skin preparation (Quality of Evidence: HIGH),– Before catheter insertion, apply an alcoholic chlorhexidine solution containing at least 2% chlorhexidine gluconate to the insertion site.The antiseptic solution must be allowed to dry before making the skin puncture.Alcoholic chlorhexidine for skin antisepsis to prevent CLABSI in NICU patients should be used when the benefits are judged to outweigh potential risk.

110Before catheter insertion, apply an alcoholic chlorhexidine solution containing at least 2% chlorhexidine gluconate to the insertion site.The antiseptic solution must be allowed to dry before making the skin puncture.Alcoholic chlorhexidine for skin antisepsis to prevent CLABSI in NICU patients should be used when the benefits are judged to outweigh potential risk.

111The antiseptic solution must be allowed to dry before making the skin puncture.

112Alcoholic chlorhexidine for skin antisepsis to prevent CLABSI in NICU patients should be used when the benefits are judged to outweigh potential risk.

113Ensure appropriate nurse-to-patient ratio and limit use of float nurses in ICUs (Quality of Evidence: HIGH), Observational studies suggest that an adequate nurse-to-patient ratio must be maintained in ICUs where nurses are managing patients with CVCs and that the number of float nurses working in the ICU environment should be minimized. Use chlorhexidine-containing dressings for CVCs in patients over 2 months of age (Quality of Evidence: HIGH),– It is unclear whether there is additional benefit with use of a chlorhexidine-containing dressing if daily chlorhexidine bathing is already established and vice-versa.For long-term catheters (eg, hemodialysis catheters) in well-healed access sites, it is unclear whether use of a chlorhexidine dressing reduces risk of infectious complications.,, For children under 2 months of age, use of chlorhexidine dressings remains unclear, particularly in very preterm or low birthweight infants. For nontunneled CVCs in adults and children, change transparent dressings and perform site care with a chlorhexidine-based antiseptic at least every 7 days or immediately if the dressing is soiled, loose, or damp. Change gauze dressings every 2 days or earlier if the dressing is soiled, loose, or damp. (Quality of Evidence: MODERATE) – Less frequent, clinically indicated dressing changes may be used for NICU patients or others at high risk of serious complications from catheter dislodgement. If there is excessive bleeding or drainage from the catheter exit site, use gauze dressings instead of transparent dressings until drainage resolves. Disinfect catheter hubs, needleless connectors, and injection ports before accessing the catheter (Quality of Evidence: MODERATE) – Before accessing catheter hubs, needleless connectors, or injection ports, vigorously apply mechanical friction with an alcoholic chlorhexidine preparation, or 70% alcohol. Alcoholic chlorhexidine may have additional residual activity compared to alcohol for this purpose and is therefore preferred. Apply mechanical friction for a minimum of 5 seconds to reduce contamination., It is unclear whether this duration of disinfection can be generalized to needleless connectors not tested in these studies.Monitor compliance with hub-connector-port disinfection because approximately half of such catheter components are colonized under conditions of standard practice.,, Remove nonessential catheters (Quality of Evidence: MODERATE)Assess the need for continued intravascular access on a daily basis during multidisciplinary rounds. Remove catheters not required for patient care. Decreasing CVC utilization reduces CRBSI risk. However, reducing CVC utilization may result in increased use of other intravascular catheters with corresponding infection risk.Audits to determine whether CVCs are routinely removed after their intended use may be helpful., Both simple and multifaceted interventions are effective at reducing unnecessary CVC use., Routine replacement of administration sets not used for blood, blood products, or lipid formulations can be performed at intervals up to 7 days (Quality of Evidence: HIGH) The optimal replacement of intermittently used administration sets is unresolved. Perform surveillance for CLABSI in ICU and non-ICU settings (Quality of Evidence: HIGH),, Measure unit-specific incidence of CLABSI (eg, CLABSI per 1,000 catheter days) and report the data on a regular basis to the units, physician and nursing leadership, and hospital administrators overseeing the units.Compare CLABSI incidence to historical data for individual units and to national rates (ie, NHSN). Audit surveillance as necessary to minimize variation in interobserver reliability.,

114Ensure appropriate nurse-to-patient ratio and limit use of float nurses in ICUs (Quality of Evidence: HIGH), Observational studies suggest that an adequate nurse-to-patient ratio must be maintained in ICUs where nurses are managing patients with CVCs and that the number of float nurses working in the ICU environment should be minimized.

115Observational studies suggest that an adequate nurse-to-patient ratio must be maintained in ICUs where nurses are managing patients with CVCs and that the number of float nurses working in the ICU environment should be minimized.

116Use chlorhexidine-containing dressings for CVCs in patients over 2 months of age (Quality of Evidence: HIGH),– It is unclear whether there is additional benefit with use of a chlorhexidine-containing dressing if daily chlorhexidine bathing is already established and vice-versa.For long-term catheters (eg, hemodialysis catheters) in well-healed access sites, it is unclear whether use of a chlorhexidine dressing reduces risk of infectious complications.,, For children under 2 months of age, use of chlorhexidine dressings remains unclear, particularly in very preterm or low birthweight infants.

117It is unclear whether there is additional benefit with use of a chlorhexidine-containing dressing if daily chlorhexidine bathing is already established and vice-versa.

118For long-term catheters (eg, hemodialysis catheters) in well-healed access sites, it is unclear whether use of a chlorhexidine dressing reduces risk of infectious complications.,,

119For children under 2 months of age, use of chlorhexidine dressings remains unclear, particularly in very preterm or low birthweight infants.

120For nontunneled CVCs in adults and children, change transparent dressings and perform site care with a chlorhexidine-based antiseptic at least every 7 days or immediately if the dressing is soiled, loose, or damp. Change gauze dressings every 2 days or earlier if the dressing is soiled, loose, or damp. (Quality of Evidence: MODERATE) – Less frequent, clinically indicated dressing changes may be used for NICU patients or others at high risk of serious complications from catheter dislodgement. If there is excessive bleeding or drainage from the catheter exit site, use gauze dressings instead of transparent dressings until drainage resolves.

121Less frequent, clinically indicated dressing changes may be used for NICU patients or others at high risk of serious complications from catheter dislodgement.

122If there is excessive bleeding or drainage from the catheter exit site, use gauze dressings instead of transparent dressings until drainage resolves.

123Disinfect catheter hubs, needleless connectors, and injection ports before accessing the catheter (Quality of Evidence: MODERATE) – Before accessing catheter hubs, needleless connectors, or injection ports, vigorously apply mechanical friction with an alcoholic chlorhexidine preparation, or 70% alcohol. Alcoholic chlorhexidine may have additional residual activity compared to alcohol for this purpose and is therefore preferred. Apply mechanical friction for a minimum of 5 seconds to reduce contamination., It is unclear whether this duration of disinfection can be generalized to needleless connectors not tested in these studies.Monitor compliance with hub-connector-port disinfection because approximately half of such catheter components are colonized under conditions of standard practice.,,

124Before accessing catheter hubs, needleless connectors, or injection ports, vigorously apply mechanical friction with an alcoholic chlorhexidine preparation, or 70% alcohol. Alcoholic chlorhexidine may have additional residual activity compared to alcohol for this purpose and is therefore preferred.

125Apply mechanical friction for a minimum of 5 seconds to reduce contamination., It is unclear whether this duration of disinfection can be generalized to needleless connectors not tested in these studies.

126Monitor compliance with hub-connector-port disinfection because approximately half of such catheter components are colonized under conditions of standard practice.,,

127Remove nonessential catheters (Quality of Evidence: MODERATE)Assess the need for continued intravascular access on a daily basis during multidisciplinary rounds. Remove catheters not required for patient care. Decreasing CVC utilization reduces CRBSI risk. However, reducing CVC utilization may result in increased use of other intravascular catheters with corresponding infection risk.Audits to determine whether CVCs are routinely removed after their intended use may be helpful., Both simple and multifaceted interventions are effective at reducing unnecessary CVC use.,

128Assess the need for continued intravascular access on a daily basis during multidisciplinary rounds. Remove catheters not required for patient care. Decreasing CVC utilization reduces CRBSI risk. However, reducing CVC utilization may result in increased use of other intravascular catheters with corresponding infection risk.

129Audits to determine whether CVCs are routinely removed after their intended use may be helpful., Both simple and multifaceted interventions are effective at reducing unnecessary CVC use.,

130Routine replacement of administration sets not used for blood, blood products, or lipid formulations can be performed at intervals up to 7 days (Quality of Evidence: HIGH) The optimal replacement of intermittently used administration sets is unresolved.

131The optimal replacement of intermittently used administration sets is unresolved.

132Perform surveillance for CLABSI in ICU and non-ICU settings (Quality of Evidence: HIGH),, Measure unit-specific incidence of CLABSI (eg, CLABSI per 1,000 catheter days) and report the data on a regular basis to the units, physician and nursing leadership, and hospital administrators overseeing the units.Compare CLABSI incidence to historical data for individual units and to national rates (ie, NHSN). Audit surveillance as necessary to minimize variation in interobserver reliability.,

133Measure unit-specific incidence of CLABSI (eg, CLABSI per 1,000 catheter days) and report the data on a regular basis to the units, physician and nursing leadership, and hospital administrators overseeing the units.

134Compare CLABSI incidence to historical data for individual units and to national rates (ie, NHSN).

135Audit surveillance as necessary to minimize variation in interobserver reliability.,

136Several additional approaches are currently available for use. Perform a CLABSI risk assessment before considering implementation of any of these approaches, taking potential adverse events and costs into consideration. Although it is reasonable to evaluate the utility of technology-based interventions when CLABSI rates are above the institutional- or unit-based threshold, this is also an opportunity to review practices and consider behavioral changes that may be instituted to reduce CLABSI risk. These additional approaches are recommended for use in locations and/or populations within the hospital with unacceptably high CLABSI rates despite implementation of the essential CLABSI prevention strategies listed above. These measures may not be indicated if institutional goals have been consistently achieved. Use antiseptic- or antimicrobial-impregnated CVCs (Quality of Evidence: HIGH in adult patients,,– and MODERATE in pediatric patients, )The risk of CLABSI is reduced with some currently marketed antiseptic-impregnated (eg, chlorhexidine-silver sulfadiazine) catheters and antimicrobial-impregnated (eg, minocycline-rifampin) catheters. Use such catheters under the following conditions:Hospital units or patient populations have a CLABSI rate above institutional goals despite compliance with essential CLABSI prevention practices. Some evidence suggests that use of antimicrobial CVCs, along with other preventive technologies, may have no additional benefit in patient care units that have already established a low incidence of catheter infections., Patients have limited venous access and a history of recurrent CLABSI.Patients are at heightened risk of severe sequelae from a CLABSI (eg, patients with recently implanted intravascular devices such as a prosthetic heart valve or aortic graft). Monitor patients for adverse effects such as anaphylaxis. Many studies investigating antimicrobial-impregnated catheters were performed before infection preventive bundles were routine. Whether such catheters have an impact on CLABSI in such settings remains unknown. Use antimicrobial lock therapy for long-term CVCs (Quality of Evidence: HIGH)– Antibiotic and antiseptic locks are created by filling the lumen of the catheter with a supratherapeutic concentration of an antibiotic solution and leaving the solution in place until the catheter hub is re-accessed. Such an approach can reduce the risk of CLABSI. The optimal antimicrobial agent or combination of agents, their concentration, and duration of lock therapy are matters of ongoing research. Due to concerns regarding the potential for the emergence of resistance in exposed organisms, use antimicrobial locks as a preventative strategy for the following:Patients with long-term hemodialysis catheters who have a history of recurrent CLABSI. Prophylaxis for patients with limited venous access and a history of recurrent CLABSI.Patients who are at heightened risk of severe sequelae from a CLABSI (eg, patients with recently implanted intravascular devices such as a prosthetic heart valve or aortic graft). To minimize systemic toxicity, aspirate rather than flush the antimicrobial lock solution after the dwell time has elapsed. – The potential of adverse effects associated with ethanol locks should be carefully considered before use., Use recombinant tissue plasminogen activating factor (rt-PA) once weekly after hemodialysis in patients undergoing hemodialysis through a CVC (Quality of Evidence: HIGH) Utilize infusion or vascular access teams for reducing CLABSI rates (Quality of Evidence: LOW), Studies have shown that an infusion/vascular access team responsible for insertion and maintenance of peripheral intravenous catheters reduces the risk of bloodstream infections; however, few studies have been performed regarding the impact of intravenous therapy teams on CLABSI rates. Use antimicrobial ointments for hemodialysis catheter insertion sites (Quality of Evidence: HIGH) – Apply polysporin “triple” (where available) or povidone-iodine ointment to hemodialysis catheter insertion if compatible with the catheter material.Ingredients in ointments may interact with the chemical composition of some catheters. Thus, ensure the selected ointment will not interact with the catheter material before any such product is applied to the catheter insertion/exit site. For example, ointments containing glycol should not be applied to insertion/exit sites of polyurethane catheters.Mupirocin ointment should not be applied to the catheter insertion site due to the risks of facilitating mupirocin resistance and the potential damage to polyurethane catheters. Use an antiseptic-containing hub/connector cap/port protector to cover connectors (Quality of Evidence: MODERATE) – The utility of routinely disinfecting hub connectors and ports when using antiseptic-containing hub/connector cap/port protectors is unknown.

137Use antiseptic- or antimicrobial-impregnated CVCs (Quality of Evidence: HIGH in adult patients,,– and MODERATE in pediatric patients, )The risk of CLABSI is reduced with some currently marketed antiseptic-impregnated (eg, chlorhexidine-silver sulfadiazine) catheters and antimicrobial-impregnated (eg, minocycline-rifampin) catheters. Use such catheters under the following conditions:Hospital units or patient populations have a CLABSI rate above institutional goals despite compliance with essential CLABSI prevention practices. Some evidence suggests that use of antimicrobial CVCs, along with other preventive technologies, may have no additional benefit in patient care units that have already established a low incidence of catheter infections., Patients have limited venous access and a history of recurrent CLABSI.Patients are at heightened risk of severe sequelae from a CLABSI (eg, patients with recently implanted intravascular devices such as a prosthetic heart valve or aortic graft). Monitor patients for adverse effects such as anaphylaxis. Many studies investigating antimicrobial-impregnated catheters were performed before infection preventive bundles were routine. Whether such catheters have an impact on CLABSI in such settings remains unknown.

138The risk of CLABSI is reduced with some currently marketed antiseptic-impregnated (eg, chlorhexidine-silver sulfadiazine) catheters and antimicrobial-impregnated (eg, minocycline-rifampin) catheters. Use such catheters under the following conditions:Hospital units or patient populations have a CLABSI rate above institutional goals despite compliance with essential CLABSI prevention practices. Some evidence suggests that use of antimicrobial CVCs, along with other preventive technologies, may have no additional benefit in patient care units that have already established a low incidence of catheter infections., Patients have limited venous access and a history of recurrent CLABSI.Patients are at heightened risk of severe sequelae from a CLABSI (eg, patients with recently implanted intravascular devices such as a prosthetic heart valve or aortic graft).

139Hospital units or patient populations have a CLABSI rate above institutional goals despite compliance with essential CLABSI prevention practices. Some evidence suggests that use of antimicrobial CVCs, along with other preventive technologies, may have no additional benefit in patient care units that have already established a low incidence of catheter infections.,

140Patients have limited venous access and a history of recurrent CLABSI.

141Patients are at heightened risk of severe sequelae from a CLABSI (eg, patients with recently implanted intravascular devices such as a prosthetic heart valve or aortic graft).

142Monitor patients for adverse effects such as anaphylaxis.

143Many studies investigating antimicrobial-impregnated catheters were performed before infection preventive bundles were routine. Whether such catheters have an impact on CLABSI in such settings remains unknown.

144Use antimicrobial lock therapy for long-term CVCs (Quality of Evidence: HIGH)– Antibiotic and antiseptic locks are created by filling the lumen of the catheter with a supratherapeutic concentration of an antibiotic solution and leaving the solution in place until the catheter hub is re-accessed. Such an approach can reduce the risk of CLABSI. The optimal antimicrobial agent or combination of agents, their concentration, and duration of lock therapy are matters of ongoing research. Due to concerns regarding the potential for the emergence of resistance in exposed organisms, use antimicrobial locks as a preventative strategy for the following:Patients with long-term hemodialysis catheters who have a history of recurrent CLABSI. Prophylaxis for patients with limited venous access and a history of recurrent CLABSI.Patients who are at heightened risk of severe sequelae from a CLABSI (eg, patients with recently implanted intravascular devices such as a prosthetic heart valve or aortic graft). To minimize systemic toxicity, aspirate rather than flush the antimicrobial lock solution after the dwell time has elapsed. – The potential of adverse effects associated with ethanol locks should be carefully considered before use.,

145Antibiotic and antiseptic locks are created by filling the lumen of the catheter with a supratherapeutic concentration of an antibiotic solution and leaving the solution in place until the catheter hub is re-accessed. Such an approach can reduce the risk of CLABSI. The optimal antimicrobial agent or combination of agents, their concentration, and duration of lock therapy are matters of ongoing research. Due to concerns regarding the potential for the emergence of resistance in exposed organisms, use antimicrobial locks as a preventative strategy for the following:Patients with long-term hemodialysis catheters who have a history of recurrent CLABSI. Prophylaxis for patients with limited venous access and a history of recurrent CLABSI.Patients who are at heightened risk of severe sequelae from a CLABSI (eg, patients with recently implanted intravascular devices such as a prosthetic heart valve or aortic graft).

146Patients with long-term hemodialysis catheters who have a history of recurrent CLABSI.

147Prophylaxis for patients with limited venous access and a history of recurrent CLABSI.

148Patients who are at heightened risk of severe sequelae from a CLABSI (eg, patients with recently implanted intravascular devices such as a prosthetic heart valve or aortic graft).

149To minimize systemic toxicity, aspirate rather than flush the antimicrobial lock solution after the dwell time has elapsed. – The potential of adverse effects associated with ethanol locks should be carefully considered before use.,

150Use recombinant tissue plasminogen activating factor (rt-PA) once weekly after hemodialysis in patients undergoing hemodialysis through a CVC (Quality of Evidence: HIGH)

151Utilize infusion or vascular access teams for reducing CLABSI rates (Quality of Evidence: LOW), Studies have shown that an infusion/vascular access team responsible for insertion and maintenance of peripheral intravenous catheters reduces the risk of bloodstream infections; however, few studies have been performed regarding the impact of intravenous therapy teams on CLABSI rates.

152Studies have shown that an infusion/vascular access team responsible for insertion and maintenance of peripheral intravenous catheters reduces the risk of bloodstream infections; however, few studies have been performed regarding the impact of intravenous therapy teams on CLABSI rates.

153Use antimicrobial ointments for hemodialysis catheter insertion sites (Quality of Evidence: HIGH) – Apply polysporin “triple” (where available) or povidone-iodine ointment to hemodialysis catheter insertion if compatible with the catheter material.Ingredients in ointments may interact with the chemical composition of some catheters. Thus, ensure the selected ointment will not interact with the catheter material before any such product is applied to the catheter insertion/exit site. For example, ointments containing glycol should not be applied to insertion/exit sites of polyurethane catheters.Mupirocin ointment should not be applied to the catheter insertion site due to the risks of facilitating mupirocin resistance and the potential damage to polyurethane catheters.

154Apply polysporin “triple” (where available) or povidone-iodine ointment to hemodialysis catheter insertion if compatible with the catheter material.

155Ingredients in ointments may interact with the chemical composition of some catheters. Thus, ensure the selected ointment will not interact with the catheter material before any such product is applied to the catheter insertion/exit site. For example, ointments containing glycol should not be applied to insertion/exit sites of polyurethane catheters.

156Mupirocin ointment should not be applied to the catheter insertion site due to the risks of facilitating mupirocin resistance and the potential damage to polyurethane catheters.

157Use an antiseptic-containing hub/connector cap/port protector to cover connectors (Quality of Evidence: MODERATE) – The utility of routinely disinfecting hub connectors and ports when using antiseptic-containing hub/connector cap/port protectors is unknown.

158The utility of routinely disinfecting hub connectors and ports when using antiseptic-containing hub/connector cap/port protectors is unknown.

159Do not use antimicrobial prophylaxis for short-term or tunneled catheter insertion or while catheters are in situ (Quality of Evidence: HIGH) – Systemic antimicrobial prophylaxis is not recommended. Do not routinely replace CVCs or arterial catheters (Quality of Evidence: HIGH) Routine catheter replacement is not recommended.

160Do not use antimicrobial prophylaxis for short-term or tunneled catheter insertion or while catheters are in situ (Quality of Evidence: HIGH) – Systemic antimicrobial prophylaxis is not recommended.

161Systemic antimicrobial prophylaxis is not recommended.

162Do not routinely replace CVCs or arterial catheters (Quality of Evidence: HIGH) Routine catheter replacement is not recommended.

163Routine catheter replacement is not recommended.

164Routine use of needleless connectors as a CLABSI prevention strategy before an assessment of risks, benefits, and education regarding proper use – Multiple devices are currently available but the optimal design for preventing infections is unresolved. The original purpose of needleless connectors was to prevent needlestick injuries during intermittent use. No data are available regarding their use with continuous infusions. Needle-free connectors with 3-way stopcocks may increase the risk of catheter infections. Use of silver-coated catheter connectors may be associated with reduced intraluminal contamination in ex vivo catheters and CLABSI., Clinical evidence is limited regarding the risk reduction with their routine use or use of other antimicrobial catheter connectors. Surveillance of other types of catheters (eg, peripheral arterial or venous catheters),, Peripheral arterial catheters, short-term peripheral venous catheters and midline catheters are not included in most surveillance systems although they are associated with risk of bloodstream infection. Future surveillance systems should consider including bloodstream infections associated with these types of catheters.If considering further infection prevention interventions due to concern for an increase in infections, hospitals may want to consider extending their surveillance programs to include all types of catheters used to gauge the size of the problem. Standard, nonantimicrobial transparent dressings and CLABSI risk A meta-analysis reported an association between CLABSI and transparent dressing use; however, the source studies for the meta-analysis reporting this association were of low quality. The impact of using chlorhexidine-based products on bacterial resistance to chlorhexidine Widespread use of chlorhexidine-based products (eg, use of chlorhexidine bathing, antisepsis, and dressings) may promote reduced chlorhexidine susceptibility. However, testing for chlorhexidine susceptibility is not standardized. The clinical impact of reduced chlorhexidine susceptibility is unknown. Sutureless securement The impact of sutureless securement devices in reducing CLABSI is unknown., Impact of silver zeolite-impregnated umbilical catheters in preterm infants (applicable in countries where it is approved for use in children) One randomized study suggests that antimicrobial-impregnated umbilical catheters appear to be safe and effective in NICU patients. Necessity of mechanical disinfection of a catheter hub, needleless connector, and injection port before accessing the catheter when antiseptic-containing caps are being used. It is unknown whether the application and removal of an antiseptic-containing cap provides the same benefit to reducing risk of CLABSI as manual disinfection. Future research is needed to determine if using such a cap will obviate the need for manual disinfection before accessing a catheter.

165Routine use of needleless connectors as a CLABSI prevention strategy before an assessment of risks, benefits, and education regarding proper use – Multiple devices are currently available but the optimal design for preventing infections is unresolved. The original purpose of needleless connectors was to prevent needlestick injuries during intermittent use. No data are available regarding their use with continuous infusions. Needle-free connectors with 3-way stopcocks may increase the risk of catheter infections. Use of silver-coated catheter connectors may be associated with reduced intraluminal contamination in ex vivo catheters and CLABSI., Clinical evidence is limited regarding the risk reduction with their routine use or use of other antimicrobial catheter connectors.

166Multiple devices are currently available but the optimal design for preventing infections is unresolved. The original purpose of needleless connectors was to prevent needlestick injuries during intermittent use. No data are available regarding their use with continuous infusions. Needle-free connectors with 3-way stopcocks may increase the risk of catheter infections. Use of silver-coated catheter connectors may be associated with reduced intraluminal contamination in ex vivo catheters and CLABSI., Clinical evidence is limited regarding the risk reduction with their routine use or use of other antimicrobial catheter connectors.

167Use of silver-coated catheter connectors may be associated with reduced intraluminal contamination in ex vivo catheters and CLABSI., Clinical evidence is limited regarding the risk reduction with their routine use or use of other antimicrobial catheter connectors.

168Surveillance of other types of catheters (eg, peripheral arterial or venous catheters),, Peripheral arterial catheters, short-term peripheral venous catheters and midline catheters are not included in most surveillance systems although they are associated with risk of bloodstream infection. Future surveillance systems should consider including bloodstream infections associated with these types of catheters.If considering further infection prevention interventions due to concern for an increase in infections, hospitals may want to consider extending their surveillance programs to include all types of catheters used to gauge the size of the problem.

169Peripheral arterial catheters, short-term peripheral venous catheters and midline catheters are not included in most surveillance systems although they are associated with risk of bloodstream infection. Future surveillance systems should consider including bloodstream infections associated with these types of catheters.

170If considering further infection prevention interventions due to concern for an increase in infections, hospitals may want to consider extending their surveillance programs to include all types of catheters used to gauge the size of the problem.

171Standard, nonantimicrobial transparent dressings and CLABSI risk A meta-analysis reported an association between CLABSI and transparent dressing use; however, the source studies for the meta-analysis reporting this association were of low quality.

172A meta-analysis reported an association between CLABSI and transparent dressing use; however, the source studies for the meta-analysis reporting this association were of low quality.

173The impact of using chlorhexidine-based products on bacterial resistance to chlorhexidine Widespread use of chlorhexidine-based products (eg, use of chlorhexidine bathing, antisepsis, and dressings) may promote reduced chlorhexidine susceptibility. However, testing for chlorhexidine susceptibility is not standardized. The clinical impact of reduced chlorhexidine susceptibility is unknown.

174Widespread use of chlorhexidine-based products (eg, use of chlorhexidine bathing, antisepsis, and dressings) may promote reduced chlorhexidine susceptibility. However, testing for chlorhexidine susceptibility is not standardized. The clinical impact of reduced chlorhexidine susceptibility is unknown.

175Sutureless securement The impact of sutureless securement devices in reducing CLABSI is unknown.,

176The impact of sutureless securement devices in reducing CLABSI is unknown.,

177Impact of silver zeolite-impregnated umbilical catheters in preterm infants (applicable in countries where it is approved for use in children) One randomized study suggests that antimicrobial-impregnated umbilical catheters appear to be safe and effective in NICU patients.

178One randomized study suggests that antimicrobial-impregnated umbilical catheters appear to be safe and effective in NICU patients.

179Necessity of mechanical disinfection of a catheter hub, needleless connector, and injection port before accessing the catheter when antiseptic-containing caps are being used. It is unknown whether the application and removal of an antiseptic-containing cap provides the same benefit to reducing risk of CLABSI as manual disinfection. Future research is needed to determine if using such a cap will obviate the need for manual disinfection before accessing a catheter.

180It is unknown whether the application and removal of an antiseptic-containing cap provides the same benefit to reducing risk of CLABSI as manual disinfection. Future research is needed to determine if using such a cap will obviate the need for manual disinfection before accessing a catheter.

181These performance measures are intended to support internal hospital quality improvement efforts, and do not necessarily address external reporting needs.

182The process and outcome measures suggested here are derived from published guidelines, other relevant literature, and the opinion of the authors. Report process and outcome measures to senior hospital leadership, nursing leadership, and clinicians who care for patients at risk for CLABSI.

183Compliance with CVC insertion guidelines as documented on an insertion checklist Assess compliance with the checklist in all hospital settings where CVCs are inserted (eg, ICUs, ED, OR, radiology, general patient care units) and assign HCP familiar with CVCs to this task.Documenting compliance using the insertion checklist upholds accountability and compliance with the proper procedure steps and identifies gaps to be mitigated. The Institute for Healthcare Improvement (IHI) provides an example of a central catheter checklist. Documentation of CVC insertion procedures in compliance with appropriate hand hygiene, use of maximal sterile barrier precautions, and use of chlorhexidine-based cutaneous antisepsis of the insertion site: Numerator: Number of CVC insertions that have documented the use of all 3 interventions (hand hygiene, maximal barrier precautions, and chlorhexidine-based cutaneous antiseptic use) performed at the time of CVC insertion. Denominator: Number of all CVC insertions.Multiply by 100 so that the measure is expressed as a percentage. Compliance with documentation of daily assessment regarding the need for continuing CVC access. Measure the percentage of patients with a CVC where there is documentation of daily assessment: Numerator: Number of patients with a CVC who have documentation of daily assessment. Denominator: Number of patients with a CVC.Multiply by 100 so that the measure is expressed as a percentage. Simulation of catheter maintenance as an alternative to address HCP competency, Numerator: Number of HCP properly simulating the aseptic infusion of medications. Denominator: Number of HCP simulating the aseptic infusion of medications.Multiply by 100 so that the measure is expressed as a percentage. Device utilization can be evaluated over time to assess any changes. Utilization may be compared at the hospital and unit level. It provides a surrogate for patient exposure risk. The standardized utilization ratio (SUR) is an NHSN measure that accounts for facility- and location-level factors that may affect device use.SUR: Observed device days divided by predicted device days.

184Compliance with CVC insertion guidelines as documented on an insertion checklist Assess compliance with the checklist in all hospital settings where CVCs are inserted (eg, ICUs, ED, OR, radiology, general patient care units) and assign HCP familiar with CVCs to this task.Documenting compliance using the insertion checklist upholds accountability and compliance with the proper procedure steps and identifies gaps to be mitigated. The Institute for Healthcare Improvement (IHI) provides an example of a central catheter checklist. Documentation of CVC insertion procedures in compliance with appropriate hand hygiene, use of maximal sterile barrier precautions, and use of chlorhexidine-based cutaneous antisepsis of the insertion site: Numerator: Number of CVC insertions that have documented the use of all 3 interventions (hand hygiene, maximal barrier precautions, and chlorhexidine-based cutaneous antiseptic use) performed at the time of CVC insertion. Denominator: Number of all CVC insertions.Multiply by 100 so that the measure is expressed as a percentage.

185Assess compliance with the checklist in all hospital settings where CVCs are inserted (eg, ICUs, ED, OR, radiology, general patient care units) and assign HCP familiar with CVCs to this task.

186Documenting compliance using the insertion checklist upholds accountability and compliance with the proper procedure steps and identifies gaps to be mitigated. The Institute for Healthcare Improvement (IHI) provides an example of a central catheter checklist.

187Documentation of CVC insertion procedures in compliance with appropriate hand hygiene, use of maximal sterile barrier precautions, and use of chlorhexidine-based cutaneous antisepsis of the insertion site: Numerator: Number of CVC insertions that have documented the use of all 3 interventions (hand hygiene, maximal barrier precautions, and chlorhexidine-based cutaneous antiseptic use) performed at the time of CVC insertion. Denominator: Number of all CVC insertions.Multiply by 100 so that the measure is expressed as a percentage.

188Numerator: Number of CVC insertions that have documented the use of all 3 interventions (hand hygiene, maximal barrier precautions, and chlorhexidine-based cutaneous antiseptic use) performed at the time of CVC insertion.

189Denominator: Number of all CVC insertions.

190Multiply by 100 so that the measure is expressed as a percentage.

191Compliance with documentation of daily assessment regarding the need for continuing CVC access. Measure the percentage of patients with a CVC where there is documentation of daily assessment: Numerator: Number of patients with a CVC who have documentation of daily assessment. Denominator: Number of patients with a CVC.Multiply by 100 so that the measure is expressed as a percentage.

192Measure the percentage of patients with a CVC where there is documentation of daily assessment: Numerator: Number of patients with a CVC who have documentation of daily assessment. Denominator: Number of patients with a CVC.Multiply by 100 so that the measure is expressed as a percentage.

193Numerator: Number of patients with a CVC who have documentation of daily assessment.

194Denominator: Number of patients with a CVC.

195Multiply by 100 so that the measure is expressed as a percentage.

196Simulation of catheter maintenance as an alternative to address HCP competency, Numerator: Number of HCP properly simulating the aseptic infusion of medications. Denominator: Number of HCP simulating the aseptic infusion of medications.Multiply by 100 so that the measure is expressed as a percentage.

197Numerator: Number of HCP properly simulating the aseptic infusion of medications.

198Denominator: Number of HCP simulating the aseptic infusion of medications.

199Multiply by 100 so that the measure is expressed as a percentage.

200Device utilization can be evaluated over time to assess any changes. Utilization may be compared at the hospital and unit level. It provides a surrogate for patient exposure risk. The standardized utilization ratio (SUR) is an NHSN measure that accounts for facility- and location-level factors that may affect device use.SUR: Observed device days divided by predicted device days.

201SUR: Observed device days divided by predicted device days.

202CLABSI rate: Use NHSN definitions. Numerator: Number of CLABSIs in each unit assessed (using NHSN definitions). Denominator: Total number of catheter days in each unit assessed (using NHSN definitions).Multiply by 1,000 so that the measure is expressed as number of CLABSIs per 1,000 catheter days. Risk adjustment: Stratify CLABSI rates by type of patient-care unit. – Report comparisons based on historic data and NHSN data, if available. Use the NHSN device standardized infection ratio (dSIR) to evaluate hospital and unit CLABSI rates.dSIR: Observed CLABSI events divided by predicted CLABSI events based on actual device days. Consider measures that address device risk at the patient population level. A population SIR (pSIR) accounts for both device SIR and SUR, reflecting both the care of the device, and interventions to reduce utilization.pSIR: Observed CLABSI events divided by predicted CLABSI events based on predicted device days.

203CLABSI rate: Use NHSN definitions. Numerator: Number of CLABSIs in each unit assessed (using NHSN definitions). Denominator: Total number of catheter days in each unit assessed (using NHSN definitions).Multiply by 1,000 so that the measure is expressed as number of CLABSIs per 1,000 catheter days.

204Numerator: Number of CLABSIs in each unit assessed (using NHSN definitions).

205Denominator: Total number of catheter days in each unit assessed (using NHSN definitions).

206Multiply by 1,000 so that the measure is expressed as number of CLABSIs per 1,000 catheter days.

207Risk adjustment: Stratify CLABSI rates by type of patient-care unit. – Report comparisons based on historic data and NHSN data, if available. Use the NHSN device standardized infection ratio (dSIR) to evaluate hospital and unit CLABSI rates.dSIR: Observed CLABSI events divided by predicted CLABSI events based on actual device days. Consider measures that address device risk at the patient population level. A population SIR (pSIR) accounts for both device SIR and SUR, reflecting both the care of the device, and interventions to reduce utilization.pSIR: Observed CLABSI events divided by predicted CLABSI events based on predicted device days.

208Report comparisons based on historic data and NHSN data, if available.

209Use the NHSN device standardized infection ratio (dSIR) to evaluate hospital and unit CLABSI rates.dSIR: Observed CLABSI events divided by predicted CLABSI events based on actual device days.

210dSIR: Observed CLABSI events divided by predicted CLABSI events based on actual device days.

211Consider measures that address device risk at the patient population level. A population SIR (pSIR) accounts for both device SIR and SUR, reflecting both the care of the device, and interventions to reduce utilization.pSIR: Observed CLABSI events divided by predicted CLABSI events based on predicted device days.

212pSIR: Observed CLABSI events divided by predicted CLABSI events based on predicted device days.

213Many challenges exist in providing useful information to consumers and other stakeholders and in preventing unintended consequences of public reporting of HAIs., Recommendations for public reporting of HAIs have been provided by the Healthcare Infection Control Practices Advisory Committee (HICPAC), the Healthcare-Associated Infection Working Group of the Joint Public Policy Committee, and the National Quality Forum.

214Hospitals in states that have mandatory reporting requirements for CLABSI must collect and report the data required by the state.For information on state and federal requirements, contact your state or local health department.

215Hospitals in states that have mandatory reporting requirements for CLABSI must collect and report the data required by the state.

216For information on state and federal requirements, contact your state or local health department.

217Hospitals that participate in external quality initiatives or state programs must collect and report the data required by the initiative or the program.Problems with interrater reliability may affect comparisons between different institutions.

218Hospitals that participate in external quality initiatives or state programs must collect and report the data required by the initiative or the program.

219Problems with interrater reliability may affect comparisons between different institutions.

220Prevention of CLABSI depends on integrating best practices to reduce the risk of infection and incorporating a culture to support implementation. Hospitals should address technical and socioadaptive components to CLABSI prevention, including formal training of HCP on indications, placement, and maintenance of devices, in addition to regular assessment of competencies.

221One example of a widely used model in the United States, known as the Four Es (ie, engage, educate, execute, and evaluate ), involves summarizing evidence, identifying local barriers to implementation, measuring performance, and ensuring that patients receive the infection prevention intervention by addressing knowledge, critical thinking, behavior and psychomotor skills, as well as attitudes and beliefs of all members of the healthcare team involved with the insertion and care of CVCs., Facilities may consider utilizing tools to promote high-reliability processes (eg, Lean Six Sigma) and to enhance teamwork (eg, Team STEPPS).

222Historically, efforts have been centered around having a champion to support CLABSI reduction initiatives. Champions are often very effective in initial phases of adoption, but their efforts may not be enough for integration of processes and sustainability. It is important to engage both frontline and senior leadership champions in the process and outcome improvement plan, but institutionalizing the work and garnering the support of stakeholder groups facilitates successful, long-lasting results.

223HCP, patients, and caregivers involved in care of a CVC should be trained in and competent, relative to their role, with the following:Appropriate indications prior to insertion.Use of full barrier precautions at the time of insertion.Daily evaluation of necessity of the device.

224Appropriate indications prior to insertion.

225Use of full barrier precautions at the time of insertion.

226Daily evaluation of necessity of the device.

227A standardized competency assessment checklist should be used to assess and document competency of each individual performing CVC insertion and procedures related to care and maintenance (eg, dressing changes). – In addition, education of the patient and/or family, as appropriate, is required for all CVC care procedures especially when transfer to an alternative setting (eg, home care, ambulatory setting) is planned.,

228Evaluation involves both process and outcome measurement. Multidisciplinary teams should set clear goals and identify the key factors to be measured. It is important for members of the healthcare team to receive feedback on their performance. Feedback should include periodic (eg, monthly, quarterly) communication (eg, e-mail messages, written reports) of process measurement data via posters, reports, or other forms of communication with graphs showing cumulative compliance with process measures. – Differences between age groups should also be considered (eg, neonates, pediatrics, and adults).,, Central line data can be used to capture trends over time. The standardized utilization ratio (SUR) provides a method for the hospital’s units to compare themselves to others with similar characteristics. CLABSI events are important to discuss with the different members of the team caring for the patient to have a clear understanding of gaps and ways to mitigate them in the future.