Genetic susceptibility to infectious diseases: big is beautiful, but will bigger be even better?

Abstract

Genetic epidemiology, including twin studies, provides robust evidence that genetic variation in human populations contributes to susceptibility to infectious disease. One of the major limitations of studies that attempt to identify the genes and mechanisms that underlie this susceptibility has been lack of power caused by small sample size. With the development of novel technologies, burgeoning information on the human genome, the HapMap project, and human genetic diversity, we are at the beginning of a new era in the study of the genetics of complex diseases. This review looks afresh at the epidemiological evidence that supports a role for genetics in susceptibility to infectious disease, examines the somewhat limited achievements to date, and discusses current advances in methodology and technology that will potentially lead to translational data in the future.

Cited by papers we hold 5

• A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection · 2023
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• Clinical Epidemiology, Risk Factors, and Control Strategies of Klebsiella pneumoniae Infection · 2021
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• Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections · 2017
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• Genetic susceptibility to non-necrotizing erysipelas/cellulitis. · 2013
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• The key role of genomics in modern vaccine and drug design for emerging infectious diseases. · 2009
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