Using intra-brain drug infusion to investigate neural mechanisms underlying reward-seeking behavior in mice
Chang Xu, Beibei Peng, Shuai Liu
STAR Protocols · 2022
doi:10.1016/j.xpro.2022.101221 (opens in a new tab)
We email you when a new notice or a question about this paper appears.
Abstract
Summary: Brain-region-specific drug infusion is a key way to investigate neural mechanisms underlying behavior and neurological diseases. Here, we present a detailed protocol for cannula implantation, intra-brain drug infusion, and two reward-seeking-related behavioral paradigms in mice: the light/dark box test and touchscreen version of progressive ratio test. In addition, we provide a user-friendly Python-based tool for behavioral data analysis. This protocol can be easily adapted to address various research questions related to behavioral pharmacology.For complete details on the use and execution of this protocol, please refer to Peng et al. (2021).
Abstract licence: CC BY-NC
Reads
Read by people on this page
None yet.
Checked or read by AI through naulon
None yet.
A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.
Are you an author?
Is this your paper?
Claim it to add your note and be paid when agents cite it. Free.