A continuous-flow protocol for photoredox-catalyzed multicomponent Petasis reaction
Monica Oliva, Frederick Martens, Erik V. Van der Eycken and 1 more
STAR Protocols · 2022
doi:10.1016/j.xpro.2022.101162 (opens in a new tab)
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Abstract
Summary: Here, we present a robust protocol for the facile and rapid synthesis of functionalized secondary amines in continuous flow. More specifically, we describe a detailed guide to perform a photocatalyzed Petasis reaction within 50 min using alkyl boronic acid as radical precursor and a Vapourtec E-series as key equipment. The desired functionalized amine has been synthesized in mmol scale and with a productivity rate of 0.2 mmol/h. The protocol is limited to alkyl boronic acids.For complete details on the generation and use of this protocol, please refer to Oliva et al. (2021).
Abstract licence: CC BY-NC
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