Protocol for a mouse CNS demyelination model induced by a combination of HSV-1 and IL-2

Summary: Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system. Although viruses have been suggested to be a contributing environmental factor, conventional experimental MS mouse models do not account for this aspect. Here, we describe a mouse model to induce and evaluate demyelinating disease with both a viral and an immune component via ocular infection with a recombinant herpes simplex virus expressing murine interleukin-2.For complete details on the use and execution of this protocol, please refer to Hirose et al. (2020).

Abstract licence: CC BY-NC

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