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Herpesvirus systematics

Andrew J. Davison

Veterinary Microbiology · 2010 · CC BY

doi:10.1016/j.vetmic.2010.02.014

Abstract

This paper is about the taxonomy and genomics of herpesviruses. Each theme is presented as a digest of current information flanked by commentaries on past activities and future directions. The International Committee on Taxonomy of Viruses recently instituted a major update of herpesvirus classification. The former family Herpesviridae was elevated to a new order, the Herpesvirales, which now accommodates 3 families, 3 subfamilies, 17 genera and 90 species. Future developments will include revisiting the herpesvirus species definition and the criteria used for taxonomic assignment, particularly in regard to the possibilities of classifying the large number of herpesviruses detected only as DNA sequences by polymerase chain reaction. Nucleotide sequence accessions in primary databases, such as GenBank, consist of the sequences plus annotations of the genetic features. The quality of these accessions is important because they provide a knowledge base that is used widely by the research community. However, updating the accessions to take account of improved knowledge is essentially reserved to the original depositors, and this activity is rarely undertaken. Thus, the primary databases are likely to become antiquated. In contrast, secondary databases are open to curation by experts other than the original depositors, thus increasing the likelihood that they will remain up to date. One of the most promising secondary databases is RefSeq, which aims to furnish the best available annotations for complete genome sequences. Progress in regard to improving the RefSeq herpesvirus accessions is discussed, and insights into particular aspects of herpesvirus genomics arising from this work are reported.

Full text

From PubMed Central, U.S. National Library of Medicine, as current on Oct 18, 2026. Paragraph numbers are ours, so an answer can point at one.

Introduction

Systematics is usually taken to be synonymous with the classification of organisms, but for the purposes of this paper I have employed a broader definition that includes both taxonomy and the systematic aspects of genomics. I address aspects of how the current situation in each area has been reached and how it might develop in future, and provide detailed summaries of current information. I also discuss a selection of new findings that have emerged from genomic studies. Readers should note that herpesvirus names are referred to in this paper not in full but by the acronyms listed in Table 1.

Taxonomy – the systematic classification of living organisms – is an exercise in categorization that helps human beings cope with the world. Of the taxa into which organisms may be classified, only those of species, genus, subfamily, family and order are presently applicable to viruses. The grouping of viruses into these taxa proceeds on the basis of identifying shared properties, and has applications in understanding virus evolution, identifying the origins of emerging diseases, and developing rational treatment strategies.

The criteria used to classify viruses have necessarily depended on the knowledge and technology available at the time. In early days, aspects of biology such as host range and broad pathogenic and epidemiological features of the disease constituted the majority of information available. With the advent of electron microscopy and physicochemical methods, data on the morphological properties and constituents of virus particles became accessible, and these are still important today in assigning viruses to higher taxa. Thus, for example, all herpesviruses share a capsid structure that consists of a DNA core surrounded by an icosahedral (20-faceted) capsid consisting of 12 pentavalent and 150 hexavalent capsomeres. The capsid is embedded in a proteinaceous matrix called the tegument, which in turn is invested in a glycoprotein-containing lipid envelope. The advent of specific antibodies facilitated the study of antigenic relationships, which are generally detectable only between closely related viruses; in the case of herpesviruses, those in the same genus. The era of nucleic acid sequencing has led to the wide application of sequence-based phylogeny to classification. Indeed, the quantitative basis and broad utility of this approach have resulted in this becoming a key taxonomical discriminator in all parts of the tree of life, to the point where it dominates all other criteria.

Resources

Advances in virus taxonomy have been recorded in a series of eight reports published at intervals since 1971 by the International Committee on Taxonomy of Viruses (ICTV). The latest report in book form was published in 2005. In deference to the electronic age, annual updates of the list of virus species were published in 2007, 2008 and 2009 at the ICTV website (http://www.ictvonline.org).

Virus classification is advanced through a voting procedure involving the members of the ICTV. The proposals on which voting takes place are prepared by the ICTV Executive Committee from submissions made by individuals in the virological community, in particular those associated with Study Groups devoted to particular virus groups (usually families). The development of taxonomy as summarized in the ICTV reports is regularly promoted, supplemented and discussed by expert publications from Study Groups, including that focused on the herpesviruses.

Past

In the first ICTV report, the genus Herpesvirus was established, consisting of 23 viruses and 4 groups of viruses named according to the usages of the day (e.g. herpesvirus of saimiri). In the second ICTV report, this genus was elevated to the family Herpetoviridae, which, presumably because of the misleading association of this name with reptiles and amphibians, was renamed Herpesviridae in the third ICTV report. Also, a formal system for naming herpesviruses was founded, implemented, elaborated and consolidated.

This naming system specified that each herpesvirus should be named after the taxon (family or subfamily) to which its primary natural host belongs. The subfamily name was used for viruses from members of the family Bovidae or from primates (the virus name ending in –ine, e.g. bovine), and the host family name for other viruses (ending in –id, e.g. equid). Human herpesviruses were treated as an exception (i.e. human rather than hominid). Following the host-derived term, the word herpesvirus was added, succeeded by an arabic number, which bore no implied meaning about the taxonomic or biological properties of the virus. Thus, the formal name of pseudorabies virus (also known as Aujeszky's disease virus) was established as suid herpesvirus 1. Since herpesviruses had previously been named on an ad hoc basis, sometimes with the effect that a virus might have several names, the formal system promised a degree of clarity and simplicity to students and scientists in the research field. However, a number of practical disadvantages of the formal naming system emerged. Most importantly, many virus names (e.g. Epstein–Barr virus) were so widely accepted that they could not be dislodged (e.g. in this case by human herpesvirus 4). This led to the use of a dual nomenclature in the literature for some herpesviruses.

Nonetheless, classification of herpesviruses continued and expanded. At the time of the third ICTV report, the family Herpesviridae was divided into 3 subfamilies (Alphaherpesvirinae, Betaherpesvirinae and Gammaherpesvirinae) and 5 unnamed genera, and 21 viruses were listed. A subsequent list compiled by the Study Group contained 89 viruses.

At the time of the seventh report, the ICTV adopted the species concept, which recognizes that a virus and the species to which it belongs fall into different categories, the real and the conceptual. This sea change put the activities of the ICTV on a more logical footing, and also limited its authority to determining formal taxonomical nomenclature and classification, and not virus names, abbreviations and vernacular usages of formal names. It also brought about a simplification by effectively removing any implied taxonomical standing for viruses denoted previously as tentative species or unassigned viruses. Moreover, it reduced tensions concerning the pervasive use of a dual system for herpesvirus names, with the effect that the ICTV approach has been adopted for some (e.g. equine abortion virus is now well known as equid herpesvirus 1) and the ad hoc name for others (e.g. Kaposi's sarcoma-associated herpesvirus, rather than human herpesvirus 8). The rules for virus taxonomical names are that they are written in italics with the first letter capitalized, and never abbreviated. Thus, for example, pseudorabies virus belongs to the species Suid herpesvirus 1, genus Varicellovirus, subfamily Alphaherpesvirinae, family Herpesviridae. If an abbreviation based on the formal name is used (in this case, SuHV1 or SuHV-1), it represents the virus and not the species.

As the classification developed, it became clear from genome studies that IcHV1 and OsHV1 are very distant relatives of each other and other herpesviruses. For this reason, a new order, Herpesvirales, was created. This accommodates three families, namely the revised family Herpesviridae, which contains mammal, bird and reptile viruses, the new family Alloherpesviridae, which incorporates bony fish and frog viruses, and the new family Malacoherpesviridae, which contains OsHV1. Also, species representing viruses of non-human primates were renamed after the host genus rather than the subfamily, in order to cope with their rising number.

Present

The most recent update (2009) of herpesvirus taxonomy largely concerned the introduction of additional taxa to the family Alloherpesviridae. The current, complete list of herpesvirus taxa is given in the first column of Table 1. This table also provides the common names and acronyms (abbreviations) of the viruses. The right-hand part of the table conveys genomic information, which is discussed below. The order Herpesvirales now consists of 3 families, 3 subfamilies, 17 genera and 90 species. A total of 48 tentative species and unassigned viruses are also listed in Table 1, but, as discussed above, these viruses are not part of formal taxonomy and are included out of convenience rather than necessity. Many are longstanding entities that may no longer exist in laboratories and for which sequence data are not (and never will be) available. Moreover, some are now known or suspected to be strains of other viruses (see the footnotes to Table 1).

Future

The ICTV Herpesvirales Study Group is continuing to progress the classification of herpesviruses as they are identified and characterized. It is also taking forward discussions that will shape herpesvirus taxonomy in future. These include revisiting the herpesvirus species definition and the criteria used for taxonomic assignment, particularly in regard to the possibilities of classifying the large number of herpesviruses detected only as DNA sequences by polymerase chain reaction (PCR).

The ICTV follows the principle that “a virus species is a polythetic class of viruses that constitutes a replicating lineage and occupies a particular ecological niche”. The polythetic nature of virus species (that is, having some but not all properties in common) implies that a species cannot be delineated on the basis of a single property. In line with this principle, herpesviruses are classified as distinct species if “(a) their nucleotide sequences differ in a readily assayable and distinctive manner across the entire genome and (b) they occupy different ecological niches by virtue of their distinct epidemiology and pathogenesis or their distinct natural hosts”. However, the dominant criterion in virus classification, as in the classification of all organisms, is now sequence-based phylogeny. The impact of this development upon the continuing viability of herpesvirus classification under the polythetic rule will need careful consideration. Discussions are likely to be driven to some extent by the ongoing PCR-based discovery of large numbers of herpesviruses that potentially belong to new taxa (e.g. ). Finally, the nomenclature of herpesvirus species is inherently unstable, because of its dependence on host nomenclature and the motivation to rename species that become very numerous in certain host families. It will be a challenge to maintain a balance between utility and stability.

Introduction

Genomics – the study of the structure, function and evolution of genomes – underlies most discoveries in modern biology. Since the inception of nucleic acid sequencing, and increasingly since, interpretation of the data has lagged behind its generation. Hence, understanding the meaning of genomic data is at a premium. Interpretation of sequence data is served greatly by computer analyses in areas such as comparative genomics, pattern-based bioinformatics and proteomics. However, it is not best advanced when treated as a robotic exercise. Genomics, even of herpesviruses, has an actively speculative edge where new discoveries are being made and old models are being refined.

Resources

The primary nucleotide sequence databases, of which perhaps the most prominent is GenBank at the National Center for Biotechnology Information (NCBI; http://www.ncbi.nlm.nih.gov), are a vital resource to experimenters. NCBI is also putting effort into the Reference Sequence Project (RefSeq; http://www.ncbi.nlm.nih.gov/RefSeq), which aims to provide a comprehensive, integrated, non-redundant, well annotated set of sequences for major research organisms, including viruses (http://www.ncbi.nlm.nih.gov/genomes/GenomesHome.cgi?taxid=10239). The herpesvirus RefSeqs are under development (http://www.ncbi.nlm.nih.gov/genomes/GenomesGroup.cgi?taxid=548681).

Past

The utility of the primary databases is limited by three major factors: the accuracy of the sequence, the quality of the annotation (i.e. the description of features in the genome—genes, RNAs, coding regions and so forth), and the improvements made to both over time. However, for understandable reasons, updating an accession is effectively restricted to the original depositor. The tendency is for this to be done rarely, if at all, and this is causing the primary databases to become antiquated. Against this background, an enterprise in updating herpesvirus accessions in primary sequence databases seems forlorn. RefSeq provides a way to counter the disadvantages of the primary databases by enabling updating and curation by experts other than the original depositor.

Present

The right-hand part of Table 1 lists information on the 51 herpesvirus species or potential species from which at least one virus has been sequenced to date. These species are represented by 122 complete or almost complete genome sequences. Partial sequence information is available on nearly all the other herpesviruses ranked in formal taxa; indeed, this is now a requirement for classification. At an experimental level, many herpesviruses are manipulated in the form of bacterial artificial chromosomes (BACs), the sequences of several of which are available; for example, those representing GaHV2, HHV1 and HHV5. The latest sequencing techniques are starting to be applied to herpesviruses, including the Roche 454 instrument (e.g. GaHV2 and MuHV1) or Illumina Genome Analyzer (e.g. HHV1 and HHV5).

I have been active in updating the herpesvirus RefSeqs, and thus far have processed all members of the subfamily Alphaherpesvirinae, plus some other viruses outside this group (e.g. HHV5). In addition to identifying potential sequence errors and upgrading the standard of annotation, one of the main tasks has been to start applying a systematic nomenclature to genome features. Members of the best studied family (Herpesviridae) in the order Herpesvirales share 44 genes apparently inherited from a common ancestor (core genes; Table 2), and yet the names of these orthologous genes and their encoded proteins vary from virus to virus. This has led to confusion in the research field. My tack has been to retain original gene names so that workers can find their way round an accession, and to apply standard names to the encoded proteins. This is aimed at improving the utility of the database accessions; for example, database searches would then return the same name for orthologous proteins from different viruses. Table 2 shows the current scheme used to annotate the RefSeqs for members of the subfamily Alphaherpesvirinae. A more extensive form of this database is available from me in spreadsheet form. As well as providing additional information, this database permits the genes and their encoded proteins to be sorted according to their order along a particular genome.

Future

The long term aim of updating herpesvirus RefSeqs is to ensure that are correct (free from errors), complete (adequately annotated), clear (using standard nomenclature) and current (up to date). From experience, I foresee that fulfilling this aim to an acceptable standard will be demanding and that many considerations will have to be weighed. Most importantly, the list of standard protein names must be considered as needing development in future, since the process of establishing names is fraught with pitfalls that are not developed further here. Thus, as with the names of herpesvirus species in Table 1, the protein names in Table 2 are provisional. It is intended that they will improve and harmonize as knowledge increases and data are imported from the other herpesvirus subfamilies. The substantial efforts of to apply a standard nomenclature to the proteins encoded by core genes also deserve recognition in this regard.

Introduction

The process of systematizing information as described above tends to yield new insights, particularly those arising from comparative genomics. This section highlights three examples that were unearthed while reannotating genomes of members of the subfamily Alphaherpesvirinae and members of the genus Cytomegalovirus in the subfamily Betaherpesvirinae. These examples illustrate the fact that new discoveries remain to be made even with well characterized herpesviruses.

UL56 gene family

Previously, I reported that orthologues of gene UL56 are not confined to members of the genus Simplexvirus in the subfamily Alphaherpesvirinae, where they were first identified, but are also found among members of the genera Varicellovirus and Iltovirus. Subsequent analysis (Fig. 1 and Table 2) indicated that orthologues are also present in members of the genus Mardivirus. These studies indicate that all members of the subfamily Alphaherpesvirinae except BoHV1 and BoHV5 encode a UL56 orthologue. The appropriate amendments were applied to the RefSeqs by the middle of 2007.

All the versions of the UL56 product (membrane protein UL56) have a C-terminal hydrophobic domain, and sequence similarity is limited to a central region consisting in most instances of two PPXY motifs (Fig. 1). Most of the proteins have additional PPXY elements elsewhere in their sequences. Moreover, two viruses (CeHV9 and PsHV1) appear to have additional genes related to UL56, whose products are termed membrane protein UL56A. The existence of these paralogues gives rise to the novel UL56 gene family. This systematic evaluation provides a framework within which to view the possible roles of the encoded proteins.

In cellular proteins, PPXY motifs interact with the WW domain, which is 35–40 residues in length and structured as a 3-stranded, antiparallel β-sheet with two ligand-binding grooves. The WW domain is invariably joined to one of a wide variety of other protein modules, and is thus implicated in assembly of multiprotein complexes. These processes encompass transcription, RNA processing, protein trafficking, receptor signaling, control of the cytoskeleton and vacuolar protein sorting. Vacuolar protein sorting is exploited for budding by some enveloped viruses, utilizing PPXY motifs in virus proteins. These observations from cellular proteins are in general accord with what is known about membrane protein UL56.

In HHV1, UL56 is not required for growth of virus in cell culture. However, mutants, including one lacking the C-terminal hydrophobic domain, are compromised in pathogenicity, including neuroinvasiveness, although this appears to depend on the system used. Moreover, mutants with lesions in UL56 and other genes have been examined for utility in oncolytic viral therapy. The protein has been detected in virions.

Additional information is available for HHV2, in which UL56 has been shown to encode a type 2 membrane protein that localizes to the Golgi apparatus and cytoplasmic vesicles, and is tail-anchored by the C-terminal hydrophobic domain so that the N terminus (containing the PPXY motifs) is located in the cytoplasm. An association of the protein has been reported with a neuron-specific kinesin (KIF1A) involved in transport of synaptic vesicle precursors in the axon, leading to the suggestion that it may function in vesicular transport. These features prompted a comparison with membrane protein US9, which is a tail-anchored, type 2 membrane protein involved in transport of virus proteins towards the axon terminus, probably in vesicles. An interaction detected between membrane protein UL56 and myristylated tegument protein (encoded by gene UL49A in HHV2; alternatively named UL49.5), and colocalization of the complex to the Golgi apparatus and aggresome-like structures, suggests that it may have a role in virus maturation and egress. Membrane protein UL56 also interacts with the ubiquitin ligase Nedd4 via its PPXY motifs and promotes its ubiquitination.

Some functional investigations have been carried out on other orthologues. Deletion of the EHV1 or SuHV1 gene has no effect on growth in cell culture, whereas the VZV protein is required for efficient growth of virus in cell culture and in an animal model system.

Gene US8A

HHV1 gene US8A (alternatively named US8.5) appeared late on the scene. It was overlooked in the genome sequence analyses, and was discovered later by. In a comparative description of the HHV2 gene content, evaluated US8A as probably specific to the genus Simplexvirus, and noted a positional counterpart in EHV1, a member of the genus Varicellovirus. characterized an internally tagged form of the HHV1 protein as locating to nucleoli. However, as registered by, the sequence used in these experiments was frameshifted, so the 16 residues at the C terminus of the protein would have been replaced. This raises a question as to whether the mutated protein might have localized inappropriately. A comparative approach (Fig. 2) indicates that the US8A protein has the sequence properties of a tail-anchored, type 2 membrane protein (N terminus in the cytoplasm). It is notable that the adjacent gene (US9) also encodes a tail-anchored, type 2 membrane protein, though it is unrelated in sequence to membrane protein US8A. A gene that is positionally equivalent to gene US8A is present in members of other genera in the subfamily Alphaherpesvirinae, and the same protein name (membrane protein US8A) is currently assigned (Table 2).

UL30A gene family

HHV5 and its closest relative (PnHV2) are members of the genus Cytomegalovirus in the subfamily Betaherpesvirinae. The UL28 coding region in these viruses was predicted several years ago to be spliced to an unidentified upstream exon. The layout of UL28 in relation to genes upstream is shown in Fig. 3a. A subsequent comparative analysis involving members or potential members of the genus Cytomegalovirus from Old and New World primates (HHV5, PnHV2, CeHV5 and CeHV8 for the former; AoHV1 and SaHV3 for the latter) strongly suggested that the upstream exon is UL29 (Fig. 3b). Reverse-transcription PCR (RT-PCR) confirmed the expression of the predicted spliced HHV5 RNA (as represented by the 450 bp RT-PCR product in Fig. 3a), as well as the unspliced RNA (as represented by the 600 bp product). The appropriate amendment to the HHV5 RefSeq was made early in 2009. The intron has also been detected independently. Thus, two previous coding regions (UL28 and UL29) present in primate members of the genus Cytomegalovirus have been conflated to a single gene (UL29).

During transcript mapping experiments, we mapped the major 5′-end upstream from HHV5 UL29 to a nucleotide position approximately 800 bp upstream from the translational initiation codon, and 300 bp upstream from the UL30 translational initiation codon (as represented by the 700 bp 5′-RACE product in Fig. 3a). This transcriptional initiation site is located an appropriate distance downstream from a candidate TATA box (Fig. 3c). Comparative analysis then led to the discovery of a potential coding region (UL30A) located in the 300 bp region between the transcriptional initiation site and the UL30 translational initiation codon. This region potentially encodes a protein that is conserved in other Old World primate members of the genus Cytomegalovirus and is related to protein UL30 (Fig. 3d). However, none of the UL30A coding regions in these viruses possesses an appropriately positioned translational initiation codon (ATG). It is possible that translational initiation occurs from a non-ATG codon, in this case ACG, which has been shown to function as an initiation codon in eukaryotic systems and viruses such as adeno-associated virus and Sendai virus. Indeed, a few respectable herpesvirus coding regions lack an ATG initiation codon and have been proposed to utilise a non-ATG codon; for example, that encoding HHV2 tegument protein UL16. The New World primate viruses that potentially belong to the genus Cytomegalovirus appear to have UL30A orthologues with ATG initiation codons, but lack UL30 orthologues (Fig. 3d). These findings indicate the presence of paralogues (UL30 and UL30A) that together constitute the novel UL30 gene family.

Conflict of interest

The author has no conflict of interest.

References 128

  1. 1.

    Afonso C.L., Tulman E.R., Lu Z., Zsak L., Rock D.L., Kutish G.F. The genome of turkey herpesvirus. J. Virol. 2001;75:971-978.

    Not in our library10.1128/jvi.75.2.971-978.2001

  2. 2.

    Albrecht J.-C. Primary structure of the Herpesvirus ateles genome. J. Virol. 2000;74:1033-1037.

    Not in our library10.1128/jvi.74.2.1033-1037.2000

  3. 3.

    Albrecht J.-C., Nicholas J., Biller D., Cameron K.R., Biesinger B., Newman C., Wittmann S., Craxton M.A., Coleman H., Fleckenstein B., Honess R.W. Primary structure of the herpesvirus saimiri genome. J. Virol. 1992;66:5047-5058.

    Not in our library10.1128/jvi.66.8.5047-5058.1992

  4. 4.

    Alexander L., Denekamp L., Knapp A., Auerbach M.R., Damania B., Desrosiers R.C. The primary sequence of rhesus monkey rhadinovirus isolate 26–95: sequence similarities to Kaposi's sarcoma-associated herpesvirus and rhesus monkey rhadinovirus isolate 17577. J. Virol. 2000;74:3388-3398.

    Not in our library10.1128/jvi.74.7.3388-3398.2000

  5. 5.

    Anderson C.W., Buzash-Pollert E. Can ACG serve as an initiation codon for protein synthesis in eucaryotic cells? Mol. Cell. Biol. 1985;5:3621-3624.

    Not in our library10.1128/mcb.5.12.3621-3624.1985

  6. 6.

    Aoki T., Hirono I., Kurokawa K., Fukuda H., Nahary R., Eldar A., Davison A.J., Waltzek T.B., Bercovier H., Hedrick R.P. Genome sequences of three koi herpesvirus isolates representing the expanding distribution of an emerging disease threatening koi and common carp worldwide. J. Virol. 2007;81:5058-5065.

    Not in our library10.1128/jvi.00146-07

  7. 7.

    Baer R., Bankier A.T., Biggin M.D., Deininger P.L., Farrell P.J., Gibson T.J., Hatfull G., Hudson G.S., Satchwell S.C., Séguin C., Tuffnell P.S., Barrell B.G. DNA sequence and expression of the B95-8 Epstein–Barr virus genome. Nature. 1984;310:207-211.

    Not in our library10.1038/310207a0

  8. 8.

    Bahr U., Darai G. Analysis and characterization of the complete genome of tupaia (tree shrew) herpesvirus. J. Virol. 2001;75:4854-4870.

    Not in our library10.1128/jvi.75.10.4854-4870.2001

  9. 9.

    Baumeister J., Klupp B.G., Mettenleiter T.C. Pseudorabies virus and equine herpesvirus 1 share a nonessential gene which is absent in other herpesviruses and located adjacent to a highly conserved gene cluster. J. Virol. 1995;69:5560-5567.

    Not in our library10.1128/jvi.69.9.5560-5567.1995

  10. 10.

    Becerra S.P., Koczot F., Fabisch P., Rose J.A. Synthesis of adeno-associated virus structural proteins requires both alternative mRNA splicing and alternative initiations from a single transcript. J. Virol. 1988;62:2745-2754.

    Not in our library10.1128/jvi.62.8.2745-2754.1988

  11. 11.

    Berkowitz C., Moyal M., Rösen-Wolff A., Darai G., Becker Y. Herpes simplex virus type 1 (HSV-1) UL56 gene is involved in viral intraperitoneal pathogenicity to immunocompetent mice. Arch. Virol. 1994;134:73-83.

    Not in our library10.1007/bf01379108

  12. 12.

    Bradley A.J., Lurain N.S., Ghazal P., Trivedi U., Cunningham C., Baluchova K., Gatherer D., Wilkinson G.W.G., Dargan D.J., Davison A.J. High-throughput sequence analysis of variants of human cytomegalovirus strains Towne and AD169. J. Gen. Virol. 2009;90:2375-2380.

    Not in our library10.1099/vir.0.013250-0

  13. 13.

    Brideau A.D., Banfield B.W., Enquist L.W. The Us9 gene product of pseudorabies virus, an alphaherpesvirus, is a phosphorylated, tail-anchored type II membrane protein. J. Virol. 1998;72:4560-4570.

    Not in our library10.1128/jvi.72.6.4560-4570.1998

  14. 14.

    Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., Horsnell T., Hutchison C.A., Kouzarides T., Martignetti J.A., Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G. Analysis of the protein coding content of the sequence of human cytomegalovirus strain AD169. Curr. Top. Microbiol. Immunol. 1990;154:125-169.

    Not in our library10.1007/978-3-642-74980-3_6

  15. 15.

    Cunningham C., Gatherer D., Hilfrich B., Baluchova K., Dargan D.J., Thomson M., Griffiths P.D., Wilkinson G.W.G., Schulz T.F., Davison A.J. Sequences of complete human cytomegalovirus genomes from infected cell cultures and clinical specimens. J. Gen. Virol. 2010;91:605-615.

    Not in our library10.1099/vir.0.015891-0

  16. 16.

    Curran J., Kolakofsky D. Ribosomal initiation from an ACG codon in the Sendai virus P/C mRNA. EMBO J. 1988;7:245-251.

    Not in our library10.1002/j.1460-2075.1988.tb02806.x

  17. 17.

    Davison A.J. Channel catfish virus: a new type of herpesvirus. Virology. 1992;186:9-14.

    Not in our library10.1016/0042-6822(92)90056-u

  18. 18.

    Davison A.J., Arvin A., Campidelli-Fiume G., Mocarski E., Moore P.S., Roizman B., Whitley R., Yamanishi K. Introduction: definition and classification of the human herpesviruses, comparative analysis of the genomes. Human Herpesviruses: Biology, Therapy and Immunoprophylaxis. 2007;10-26.

    Not in our library

  19. 19.

    Davison A.J., Scott J.E. The complete DNA sequence of varicella-zoster virus. J. Gen. Virol. 1986;67:1759-1816.

    Not in our library10.1099/0022-1317-67-9-1759

  20. 20.

    Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S. The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome. J. Gen. Virol. 2003;84:17-28.

    Not in our library10.1099/vir.0.18606-0

  21. 21.

    Davison A., Eberle R., Hayward G.S., McGeoch D.J., Minson A.C., Pellett P.E., Roizman B., Studdert M.J., Thiry E., Fauquet C.M., Mayo M.A., Maniloff J., Desselberger U., Ball L.A. Herpesviridae. Virus Taxonomy: Classification and Nomenclature of Viruses, Eighth Report of the International Committee on Taxonomy of Viruses. 2005.

    Not in our library

  22. 22.

    Davison A.J., Trus B.L., Cheng N., Steven A.C., Watson M.S., Cunningham C., Le Deuff R.-M., Renault T. A novel class of herpesvirus with bivalve hosts. J. Gen. Virol. 2005;86:41-53.

    Not in our library10.1099/vir.0.80382-0

  23. 23.

    Davison A.J., Cunningham C., Sauerbier W., McKinnell R.G. Genome sequences of two frog herpesviruses. J. Gen. Virol. 2006;87:3509-3514.

    Not in our library10.1099/vir.0.82291-0

  24. 24.

    Davison A.J., Eberle R., Ehlers B., Hayward G.S., McGeoch D.J., Minson A.C., Pellett P.E., Roizman B., Studdert M.J., Thiry E. The order Herpesvirales. Arch. Virol. 2009;154:171-177.

    Not in our library10.1007/s00705-008-0278-4

  25. 25.

    de Jesus O., Smith P.R., Spender L.C., Elgueta Karstegl C., Niller H.H., Huang D., Farrell P.J. Updated Epstein–Barr virus (EBV) DNA sequence and analysis of a promoter for the BART (CST, BARF0) RNAs of EBV. J. Gen. Virol. 2003;84:1443-1450.

    Not in our library10.1099/vir.0.19054-0

  26. 26.

    Delhon G., Moraes M.P., Lu Z., Afonso C.L., Flores E.F., Weiblen R., Kutish G.F., Rock D.L. Genome of bovine herpesvirus 5. J. Virol. 2003;77:10339-10347.

    Not in our library10.1128/jvi.77.19.10339-10347.2003

  27. 27.

    Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J. The genome sequence of herpes simplex virus type 2. J. Virol. 1998;72:2010-2021.

    Not in our library10.1128/jvi.72.3.2010-2021.1998

  28. 28.

    Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L., Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C., Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J. Genetic content of wild type human cytomegalovirus. J. Gen. Virol. 2004;85:1301-1312.

    Not in our library10.1099/vir.0.79888-0

  29. 29.

    Dolan A., Addison C., Gatherer D., Davison A.J., McGeoch D.J. The genome of Epstein–Barr virus type 2 strain AG876. Virology. 2006;350:164-170.

    Not in our library10.1016/j.virol.2006.01.015

  30. 30.

    Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N., Pellett P.E. Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A. J. Virol. 1999;73:8040-8052.

    Not in our library10.1128/jvi.73.10.8040-8052.1999

  31. 31.

    Dunn W., Chou C., Li H., Hai R., Patterson D., Stolc V., Zhu H., Liu F. Functional profiling of a human cytomegalovirus genome. Proc. Natl. Acad. Sci. U.S.A. 2003;100:14223-14228.

    Not in our library10.1073/pnas.2334032100

  32. 32.

    Ebeling A., Keil G., Nowak B., Fleckenstein B., Berthelot N., Sheldrick P. Genome structure and virion polypeptides of the primate herpesviruses Herpesvirus aotus types 1 and 3: comparison with human cytomegalovirus. J. Virol. 1983;45:715-726.

    Not in our library10.1128/jvi.45.2.715-726.1983

  33. 33.

    Ehlers B., Dural G., Yasmum N., Lembo T., de Thoisy B., Ryser-Degiorgis M.-P., Ulrich R.G., McGeoch D.J. Novel mammalian herpesviruses and lineages within the Gammaherpesvirinae: cospeciation and interspecies transfer. J. Virol. 2008;82:3509-3516.

    Not in our library10.1128/jvi.02646-07

  34. 34.

    Ensser A., Pflanz R., Fleckenstein B. Primary structure of the alcelaphine herpesvirus 1 genome. J. Virol. 1997;71:6517-6525.

    Not in our library10.1128/jvi.71.9.6517-6525.1997

  35. 35.

    Ensser A., Thurau M., Wittmann S., Fickenscher H. The genome of herpesvirus saimiri C488 which is capable of transforming human T cells. Virology. 2003;314:471-487.

    Not in our library10.1016/s0042-6822(03)00449-5

  36. 36.

    Fauquet C.M., Mayo M.A., Maniloff J., Desselberger U., Ball L.A. Virus Taxonomy: Classification and Nomenclature of Viruses, Eighth Report of the International Committee on Taxonony of Viruses. 2005.

    Not in our library

  37. 37.

    Fenner F. Classification and nomenclature of viruses. Second Report of the International Committee on Taxonomy of Viruses. Intervirology. 1976;7:1-115.

    Not in our library10.1159/000149938

  38. 38.

    Francki R.I.B., Fauquet C.M., Knudson D.L., Brown F. Classification and nomenclature of viruses, Fifth Report of the International Committee on Taxonomy of Viruses. Arch. Virol. 1991;Suppl. 2:103-110.

    Not in our library

  39. 39.

    Gailbreath K.L., Oaks J.L. Herpesviral inclusion body disease in owls and falcons is caused by the pigeon herpesvirus (columbid herpesvirus 1). J. Wildl. Dis. 2008;44:427-433.

    Not in our library10.7589/0090-3558-44.2.427

  40. 40.

    Georgopoulou U., Michaelidou B., Roizman B., Mavromara-Nazos P. Identification of a new transcriptional unit that yields a gene product within the unique sequences of the short component of the herpes simplex virus 1 genome. J. Virol. 1993;67:3961-3968.

    Not in our library10.1128/jvi.67.7.3961-3968.1993

  41. 41.

    Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M., Yamanishi K. Comparison of the complete DNA sequences of the Oka varicella vaccine and its parental virus. J. Virol. 2002;76:11447-11459.

    Not in our library10.1128/jvi.76.22.11447-11459.2002

  42. 42.

    Gompels U.A., Nicholas J., Lawrence G., Jones M., Thomson B.J., Martin M.E.D., Efstathiou S., Craxton M., Macaulay H.A. The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution. Virology. 1995;209:29-51.

    Not in our library10.1006/viro.1995.1228

  43. 43.

    Gray W.L., Starnes B., White M.W., Mahalingam R. The DNA sequence of the simian varicella virus genome. Virology. 2001;284:123-130.

    Not in our library10.1006/viro.2001.0912

  44. 44.

    Grose C., Tyler S., Peters G., Hiebert J., Stephens G.M., Ruyechan W.T., Jackson W., Storlie J., Tipples G.A. Complete DNA sequence analyses of the first two varicella–zoster virus glycoprotein E (D150N) mutant viruses found in North America: evolution of genotypes with an accelerated cell spread phenotype. J. Virol. 2004;78:6799-6807.

    Not in our library10.1128/jvi.78.13.6799-6807.2004

  45. 45.

    Hansen S.G., Strelow L.I., Franchi D.C., Anders D.G., Wong S.W. Complete sequence and genomic analysis of rhesus cytomegalovirus. J. Virol. 2003;77:6620-6636.

    Not in our library10.1128/jvi.77.12.6620-6636.2003

  46. 46.

    Hart J., Ackermann M., Jayawardane G., Russell G., Haig D.M., Reid H., Stewart J.P. Complete sequence and analysis of the ovine herpesvirus 2 genome. J. Gen. Virol. 2007;88:28-39.

    Not in our library10.1099/vir.0.82284-0

  47. 47.

    Hettema E.H., Valdez-Taubas J., Pelham H.R.B. Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins. EMBO J. 2004;23:1279-1288.

    Not in our library10.1038/sj.emboj.7600137

  48. 48.

    Hughes D.J., Kipar A., Milligan S.G., Cunningham C., Sanders M., Quail M.A., Rajandream M.A., Efstathiou S., Bowden R.J., Chastel C., Bennett M., Sample J.T., Barrell B., Davison A.J., Stewart J.P. Characterization of a novel wood mouse virus related to murid herpesvirus 4. J. Gen. Virol. 2010;91:867-879.

    Not in our library10.1099/vir.0.017327-0

  49. 49.

    Ingham R.J., Colwill K., Howard C., Dettwiler S., Lim C.S.H., Yu J., Hersi K., Raaijmakers J., Gish G., Mbamalu G., Taylor L., Yeung B., Vassilovski G., Amin M., Chen F., Matskova L., Winberg G., Ernberg I., Linding R., O’Donnell P., Starostine A., Keller W., Metalnikov P., Stark C., Pawson T. WW domains provide a platform for the assembly of multiprotein networks. Mol. Cell. Biol. 2005;25:7092-7106.

    Not in our library10.1128/mcb.25.16.7092-7106.2005

  50. 50.

    Isegawa Y., Mukai T., Nakano K., Kagawa M., Chen J., Mori Y., Sunagawa T., Kawanishi K., Sashihara J., Hata A., Zou P., Kosuge H., Yamanishi K. Comparison of the complete DNA sequences of human herpesvirus 6 variants A and B. J. Virol. 1999;73:8053-8063.

    Not in our library10.1128/jvi.73.10.8053-8063.1999

  51. 51.

    Izumiya Y., Jang H.K., Ono M., Mikami T. A complete genomic DNA sequence of Marek's disease virus type 2, strain HPRS24. Curr. Top. Microbiol. Immunol. 2001;255:191-221.

    Not in our library10.1007/978-3-642-56863-3_8

  52. 52.

    Kehm R., Lorentzen E., Rösen-Wolff A., Darai G. In vitro expression of UL56 gene of herpes simplex virus type 1; detection of UL56 gene product in infected cells and in virions. Virus Res. 1994;33:55-66.

    Not in our library10.1016/0168-1702(94)90017-5

  53. 53.

    Kehm R., Rösen-Wolff A., Darai G. Restitution of the UL56 gene expression of HSV-1 HFEM led to restoration of virulent phenotype; deletion of the amino acids 217 to 234 of the UL56 protein abrogates the virulent phenotype. Virus Res. 1996;40:17-31.

    Not in our library10.1016/0168-1702(96)80248-6

  54. 54.

    Kehm R., Gelderblom H.R., Darai G. Identification of the UL56 protein of herpes simplex virus type 1 within the virion by immuno electron microscopy. Virus Genes. 1998;17:49-53.

    Not in our library10.1023/a:1008053017716

  55. 55.

    Kingham B.F., Zelník V., Kopáček J., Majerčiak V., Ney E., Schmidt C.J. The genome of herpesvirus of turkeys: comparative analysis with Marek's disease viruses. J. Gen. Virol. 2001;82:1123-1135.

    Not in our library10.1099/0022-1317-82-5-1123

  56. 56.

    Klupp B.G., Hengartner C.J., Mettenleiter T.C., Enquist L.W. Complete, annotated sequence of the pseudorabies virus genome. J. Virol. 2004;78:424-440.

    Not in our library10.1128/jvi.78.1.424-440.2004

  57. 57.

    Koshizuka T., Goshima F., Takakuwa H., Nozawa N., Daikoku T., Koiwai O., Nishiyama Y. Identification and characterization of the UL56 gene product of herpes simplex virus type 2. J. Virol. 2002;76:6718-6728.

    Not in our library10.1128/jvi.76.13.6718-6728.2002

  58. 58.

    Koshizuka T., Kawaguchi Y., Nishiyama Y. Herpes simplex virus type 2 membrane protein UL56 associates with the kinesin motor protein KIF1A. J. Gen. Virol. 2005;86:527-533.

    Not in our library10.1099/vir.0.80633-0

  59. 59.

    Koshizuka T., Kawaguchi Y., Goshima F., Mori I., Nishiyama Y. Association of two membrane proteins encoded by herpes simplex virus type 2, UL11 and UL56. Virus Genes. 2006;32:153-163.

    Not in our library10.1007/s11262-005-6871-7

  60. 60.
    The complete unique long sequence and the overall genomic organization of the GA strain of Marek's disease virus · 2000
    Not checked
  61. 61.

    Li Y., Huang B., Ma X., Wu J., Li F., Ai W., Song M., Yang H. Molecular characterization of the genome of duck enteritis virus. Virology. 2009;391:151-161.

    Not in our library10.1016/j.virol.2009.06.018

  62. 62.

    Loparev V.N., Rubtcova E.N., Bostik V., Tzaneva V., Sauerbrei A., Robo A., Sattler-Dornbacher E., Hanovcova I., Stepanova V., Splino M., Eremin V., Koskiniemi M., Vankova O.E., Schmid D.S. Distribution of varicella-zoster virus (VZV) wild-type genotypes in northern and southern Europe: evidence for high conservation of circulating genotypes. Virology. 2009;383:216-225.

    Not in our library10.1016/j.virol.2008.10.026

  63. 63.

    Lyman M.G., Feierbach B., Curanovic D., Bisher M., Enquist L.W. Pseudorabies virus Us9 directs axonal sorting of viral capsids. J. Virol. 2007;81:11363-11371.

    Not in our library10.1128/jvi.01281-07

  64. 64.

    Macias M.J., Hyvonen M., Baraldi E., Schultz J., Sudol M., Saraste M., Oschkinat H. Structure of the WW domain of a kinase-associated protein complexed with a proline-rich peptide. Nature. 1996;382:646-649.

    Not in our library10.1038/382646a0

  65. 65.

    Martin-Serrano J., Eastman S.W., Chung W., Bieniasz P.D. HECT ubiquitin ligases link viral and cellular PPXY motifs to the vacuolar protein-sorting pathway. J. Cell Biol. 2005;168:89-101.

    Not in our library10.1083/jcb.200408155

  66. 66.

    Matthews R.E.F. Classification and nomenclature of viruses, Third Report of the International Committee on Taxonomy of Viruses. Intervirology. 1979;12:129-296.

    Not in our library10.1159/000149081

  67. 67.

    McGeoch D.J., Dolan A., Donald S., Rixon F.J. Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1. J. Mol. Biol. 1985;181:1-13.

    Not in our library10.1016/0022-2836(85)90320-1

  68. 68.

    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. 1988;69:1531-1574.

    Not in our library10.1099/0022-1317-69-7-1531

  69. 69.

    Megaw A.G., Rapaport D., Avidor B., Frenkel N., Davison A.J. The DNA sequence of the RK strain of human herpesvirus 7. Virology. 1998;244:119-132.

    Not in our library10.1006/viro.1998.9105

  70. 70.

    Minson A.C., Davison A., Eberle R., Desrosiers R.C., Fleckenstein B., McGeoch D.J., Pellett P.E., Roizman B., Studdert M.J., Van Regenmortel M.H.V., Fauquet C.M., Bishop D.H.L., Carstens E.B., Estes M.K., Lemon S.M., Maniloff J., Mayo M.A., McGeoch D.J., Pringle C.R., Wickner R.B. Family Herpesviridae. Virus Taxonomy: Classification and Nomenclature of Viruses, Seventh Report of the International Committee on Taxonomy of Viruses. 2000;203-225.

    Not in our library

  71. 71.

    Mitchell D.P., Savaryn J.P., Moorman N.J., Shenk T., Terhune S.S. Human cytomegalovirus UL28 and UL29 open reading frames encode a spliced mRNA and stimulate accumulation of immediate-early RNAs. J. Virol. 2009;83:10187-10197.

    Not in our library10.1128/jvi.00396-09

  72. 72.

    Mocaski E.S., Arvin A., Campidelli-Fiume G., Mocarski E., Moore P.S., Roizman B., Whitley R., Yamanishi K. Introduction: definition and classification of the human herpesviruses, comparative analysis of herpesvirus-common proteins. Human Herpesviruses: Biology, Therapy and Immunoprophylaxis. 2007;44-58.

    Not in our library

  73. 73.

    Murphy E., Yu D., Grimwood J., Schmutz J., Dickson M., Jarvis M.A., Hahn G., Nelson J.A., Myers R.M., Shenk T.E. Coding potential of laboratory and clinical strains of human cytomegalovirus. Proc. Natl. Acad. Sci. U.S.A. 2003;100:14976-14981.

    Not in our library10.1073/pnas.2136652100

  74. 74.

    Nash A.A., Dutia B.M., Stewart J.P., Davison A.J. Natural history of murine γ-herpesvirus infection. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2001;356:569-579.

    Not in our library10.1098/rstb.2000.0779

  75. 75.

    Nash T.C., Spivack J.G. The UL55 and UL56 genes of herpes simplex virus type 1 are not required for viral replication, intraperitoneal virulence, or establishment of latency in mice. Virology. 1994;204:794-798.

    Not in our library10.1006/viro.1994.1595

  76. 76.

    Neipel F., Albrecht J.-C., Fleckenstein B. Cell-homologous genes in the Kaposi's sarcoma-associated rhadinovirus human herpesvirus 8: determinants of its pathogenicity? J. Virol. 1997;71:4187-4192.

    Not in our library10.1128/jvi.71.6.4187-4192.1997

  77. 77.

    Nicholas J. Determination and analysis of the complete nucleotide sequence of human herpesvirus 7. J. Virol. 1996;70:5975-5989.

    Not in our library10.1128/jvi.70.9.5975-5989.1996

  78. 78.

    Niikura M., Dodgson J., Cheng H. Direct evidence of host genome acquisition by the alphaherpesvirus Marek's disease virus. Arch. Virol. 2006;151:537-549.

    Not in our library10.1007/s00705-005-0633-7

  79. 79.

    Norberg P., Liljeqvist J.-A., Bergström T., Sammons S., Schmid D.S., Loparev V.N. Complete-genome phylogenetic approach to varicella–zoster virus evolution: genetic divergence and evidence for recombination. J. Virol. 2006;80:9569-9576.

    Not in our library10.1128/jvi.00835-06

  80. 80.

    Nugent J., Birch-Machin I., Smith K.C., Mumford J.A., Swann Z., Newton J.R., Bowden R.J., Allen G.P., Davis-Poynter N. Analysis of equid herpesvirus 1 strain variation reveals a point mutation of the DNA polymerase strongly associated with neuropathogenic versus nonneuropathogenic disease outbreaks. J. Virol. 2006;80:4047-4060.

    Not in our library10.1128/jvi.80.8.4047-4060.2006

  81. 81.

    Peabody D.S. Translation initiation at non-AUG triplets in mammalian cells. J. Biol. Chem. 1989;264:5031-5035.

    Not in our library

  82. 82.

    Peles E., Rosen H., Darai G., Rösen-Wolff A., Becker Y. Importance of the HpaI-P sequence for herpes simplex virus-1 replication in the adrenal glands. Arch. Virol. 1990;113:151-163.

    Not in our library10.1007/bf01316669

  83. 83.

    Perelygina L., Zhu L., Zurkuhlen H., Mills R., Borodovsky M., Hilliard J.K. Complete sequence and comparative analysis of the genome of herpes B virus (Cercopithecine herpesvirus 1) from a rhesus monkey. J. Virol. 2003;77:6167-6177.

    Not in our library10.1128/jvi.77.11.6167-6177.2003

  84. 84.

    Peters G.A., Tyler S.D., Grose C., Severini A., Gray M.J., Upton C., Tipples G.A. A full-genome phylogenetic analysis of varicella–zoster virus reveals a novel origin of replication-based genotyping scheme and evidence of recombination between major circulating clades. J. Virol. 2006;80:9850-9860.

    Not in our library10.1128/jvi.00715-06

  85. 85.

    Pruitt K.D., Tatusova T., Maglott D.R. NCBI Reference Sequence Project: update and current status. Nucleic Acids Res. 2003;31:34-37.

    Not in our library10.1093/nar/gkg111

  86. 86.

    Rawlinson W.D., Farrell H.E., Barrell B.G. Analysis of the complete DNA sequence of murine cytomegalovirus. J. Virol. 1996;70:8833-8849.

    Not in our library10.1128/jvi.70.12.8833-8849.1996

  87. 87.

    Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J. Kaposi's sarcoma-associated herpesvirus immune modulation: an overview. J. Gen. Virol. 2006;87:1781-1804.

    Not in our library10.1099/vir.0.81919-0

  88. 88.

    Rivailler P., Cho Y.-G., Wang F. Complete genomic sequence of an Epstein–Barr virus-related herpesvirus naturally infecting a new world primate: a defining point in the evolution of oncogenic lymphocryptoviruses. J. Virol. 2002;76:12055-12068.

    Not in our library10.1128/jvi.76.23.12055-12068.2002

  89. 89.

    Rivailler P., Jiang H., Cho Y.-G., Quink C., Wang F. Complete nucleotide sequence of the rhesus lymphocryptovirus: genetic validation for an Epstein–Barr virus animal model. J. Virol. 2002;76:421-426.

    Not in our library10.1128/jvi.76.1.421-426.2002

  90. 90.

    Rivailler P., Kaur A., Johnson R.P., Wang F. Genomic sequence of rhesus cytomegalovirus 180.92: insights into the coding potential of rhesus cytomegalovirus. J. Virol. 2006;80:4179-4182.

    Not in our library10.1128/jvi.80.8.4179-4182.2006

  91. 91.

    Roizman B., Bartha A., Biggs P.M., Carmichael L.E., Granoff A., Hampar B., Kaplan A.S., Melendez L.V., Munk K., Nahmias A., Plummer G., Rajcani J., Rapp F., Terni M., de Thé G., Watson D.H., Wildy P. Provisional labels for herpesviruses. J. Gen. Virol. 1973;20:417-419.

    Not in our library10.1099/0022-1317-20-3-417

  92. 92.

    Roizman B., Carmichael L.E., Deinhardt F., de-Thé G., Nahmias A.J., Plowright W., Rapp F., Sheldrick P., Takahashi M., Wolf K. Herpesviridae: definition, provisional nomenclature, and taxonomy. Intervirology. 1981;16:201-217.

    Not in our library10.1159/000149269

  93. 93.

    Roizman B., Desrosiers R.C., Fleckenstein B., Lopez C., Minson A.C., Studdert M.J. The family Herpesviridae: an update. Arch. Virol. 1992;123:425-449.

    Not in our library10.1007/bf01317276

  94. 94.

    Rösen-Wolff A., Lamadé W., Berkowitz C., Becker Y., Darai G. Elimination of UL56 gene by insertion of LacZ cassette between nucleotide position 116030 to 121753 of the herpes simplex virus type 1 genome abrogates intraperitoneal pathogenicity in tree shrews and mice. Virus Res. 1991;20:205-221.

    Not in our library10.1016/0168-1702(91)90076-8

  95. 95.

    Russo J.J., Bohenzky R.A., Chien M.-C., Chen J., Yan M., Maddalena D., Parry J.P., Peruzzi D., Edelman I.S., Chang Y., Moore P.S. Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc. Natl. Acad. Sci. U.S.A. 1996;93:14862-14867.

    Not in our library10.1073/pnas.93.25.14862

  96. 96.

    Schleiss M.R., McGregor A., Choi K.Y., Date S.V., Cui X., McVoy M.A. Analysis of the nucleotide sequence of the guinea pig cytomegalovirus (GPCMV) genome. Virol. J. 2008;5:139.

    Not in our library10.1186/1743-422x-5-139

  97. 97.

    Schwyzer M., Ackermann M. Molecular virology of ruminant herpesviruses. Vet. Microbiol. 1996;53:17-29.

    Not in our library10.1016/s0378-1135(96)01231-x

  98. 98.

    Searles R.P., Bergquam E.P., Axthelm M.K., Wong S.W. Sequence and genomic analysis of a rhesus macaque rhadinovirus with similarity to Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8. J. Virol. 1999;73:3040-3053.

    Not in our library10.1128/jvi.73.4.3040-3053.1999

  99. 99.

    Sinzger C., Hahn G., Digel M., Katona R., Sampaio K.L., Messerle M., Hengel H., Koszinowski U., Brune W., Adler B. Cloning and sequencing of a highly productive, endotheliotropic virus strain derived from human cytomegalovirus TB40/E. J. Gen. Virol. 2008;89:359-368.

    Not in our library10.1099/vir.0.83286-0

  100. 100.

    Smith L.M., McWhorter A.R., Masters L.L., Shellam G.R., Redwood A.J. Laboratory strains of murine cytomegalovirus are genetically similar to but phenotypically distinct from wild strains of virus. J. Virol. 2008;82:6689-6696.

    Not in our library10.1128/jvi.00160-08

  101. 101.

    Spatz S.J., Rue C.A. Sequence determination of a mildly virulent strain (CU-2) of Gallid herpesvirus type 2 using 454 pyrosequencing. Virus Genes. 2008;36:479-489.

    Not in our library10.1007/s11262-008-0213-5

  102. 102.

    Spatz S.J., Petherbridge L., Zhao Y., Nair V. Comparative full-length sequence analysis of oncogenic and vaccine (Rispens) strains of Marek's disease virus. J. Gen. Virol. 2007;88:1080-1096.

    Not in our library10.1099/vir.0.82600-0

  103. 103.

    Spatz S.J., Zhao Y., Petherbridge L., Smith L.P., Baigent S.J., Nair V. Comparative sequence analysis of a highly oncogenic but horizontal spread-defective clone of Marek's disease virus. Virus Genes. 2007;35:753-766.

    Not in our library10.1007/s11262-007-0157-1

  104. 104.

    Spatz S.J., Rue C., Schumacher D., Osterrieder N. Clustering of mutations within the inverted repeat regions of a serially passaged attenuated gallid herpesvirus type 2 strain. Virus Genes. 2008;37:69-80.

    Not in our library10.1007/s11262-008-0242-0

  105. 105.

    Sugiura S., Goshima F., Takakuwa H., Sata T., Nakashima T., Nishiyama Y. Treatment of solid sarcomas in immunocompetent mice with novel, oncolytic herpes simplex viruses. Otolaryngol. Head Neck Surg. 2004;130:470-478.

    Not in our library10.1016/j.otohns.2004.01.001

  106. 106.

    Sun Y., Brown S.M. The open reading frames 1, 2, 71, and 75 are nonessential for the replication of equine herpesvirus type 1 in vitro. Virology. 1994;199:448-452.

    Not in our library10.1006/viro.1994.1143

  107. 107.

    Takakuwa H., Goshima F., Nozawa N., Yoshikawa T., Kimata H., Nakao A., Nawa A., Kurata T., Sata T., Nishiyama Y. Oncolytic viral therapy using a spontaneously generated herpes simplex virus type 1 variant for disseminated peritoneal tumor in immunocompetent mice. Arch. Virol. 2003;148:813-825.

    Not in our library10.1007/s00705-002-0944-x

  108. 108.

    Taus N.S., Herndon D.R., Traul D.L., Stewart J.P., Ackermann M., Li H., Knowles D.P., Lewis G.S., Brayton K.A. Comparison of ovine herpesvirus 2 genomes isolated from domestic sheep (Ovis aries) and a clinically affected cow (Bos bovis). J. Gen. Virol. 2007;88:40-45.

    Not in our library10.1099/vir.0.82285-0

  109. 109.

    Telford E.A.R., Watson M.S., McBride K., Davison A.J. The DNA sequence of equine herpesvirus-1. Virology. 1992;189:304-316.

    Not in our library10.1016/0042-6822(92)90706-u

  110. 110.

    Telford E.A.R., Watson M.S., Aird H.C., Perry J., Davison A.J. The DNA sequence of equine herpesvirus 2. J. Mol. Biol. 1995;249:520-528.

    Not in our library10.1006/jmbi.1995.0314

  111. 111.

    Telford E.A.R., Watson M.S., Perry J., Cullinane A.A., Davison A.J. The DNA sequence of equine herpesvirus-4. J. Gen. Virol. 1998;79:1197-1203.

    Not in our library10.1099/0022-1317-79-5-1197

  112. 112.

    Thureen D.R., Keeler C.L. Psittacid herpesvirus 1 and infectious laryngotracheitis virus: comparative genome sequence analysis of two avian alphaherpesviruses. J. Virol. 2006;80:7863-7872.

    Not in our library10.1128/jvi.00134-06

  113. 113.

    Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M., Vassilev V. Complete DNA sequences of two Oka strain varicella-zoster virus genomes. J. Virol. 2008;82:11023-11044.

    Not in our library10.1128/jvi.00777-08

  114. 114.

    Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F. The genome of a very virulent Marek's disease virus. J. Virol. 2000;74:7980-7988.

    Not in our library10.1128/jvi.74.17.7980-7988.2000

  115. 115.

    Tyler S.D., Peters G.A., Severini A. Complete genome sequence of cercopithecine herpesvirus 2 (SA8) and comparison with other simplexviruses. Virology. 2005;331:429-440.

    Not in our library10.1016/j.virol.2004.09.042

  116. 116.

    Tyler S.D., Severini A. The complete genome sequence of herpesvirus papio 2 (Cercopithecine herpesvirus 16) shows evidence of recombination events among various progenitor herpesviruses. J. Virol. 2006;80:1214-1221.

    Not in our library10.1128/jvi.80.3.1214-1221.2006

  117. 117.

    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y. Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus. Microbes Infect. 2007;9:142-149.

    Not in our library10.1016/j.micinf.2006.10.019

  118. 118.

    Ushijima Y., Koshizuka T., Goshima F., Kimura H., Nishiyama Y. Herpes simplex virus type 2 UL56 interacts with the ubiquitin ligase Nedd4 and increases its ubiquitination. J. Virol. 2008;82:5220-5233.

    Not in our library10.1128/jvi.02515-07

  119. 119.

    van Beurden S.J., Bossers A., Voorbergen-Laarman M.H., Haenen O.L., Peters S., Abma-Henkens M.H., Peeters B.P., Rottier P.J., Engelsma M.Y. Complete genome sequence and taxonomic position of anguillid herpesvirus 1. J. Gen. Virol. 2010;91:880-887.

    Not in our library10.1099/vir.0.016261-0

  120. 120.

    Van Regenmortel M.H. Virus species, a much overlooked but essential concept in virus classification. Intervirology. 1990;31:241-254.

    Not in our library10.1159/000150159

  121. 121.

    Van Regenmortel M.H. What is a virus? Arch. Virol. 1992;Suppl. 5:47-53.

    Not in our library10.1007/978-3-7091-6920-9_5

  122. 122.

    Vink C., Beuken E., Bruggeman C.A. Complete DNA sequence of the rat cytomegalovirus genome. J. Virol. 2000;74:7656-7665.

    Not in our library10.1128/jvi.74.16.7656-7665.2000

  123. 123.

    Virgin H.W., Latreille P., Wamsley P., Hallsworth K., Weck K.E., Dal Canto A.J., Speck S.H. Complete sequence and genomic analysis of murine gammaherpesvirus 68. J. Virol. 1997;71:5894-5904.

    Not in our library10.1128/jvi.71.8.5894-5904.1997

  124. 124.

    Wildy, P., 1971. First Report of the International Committee on Nomenclature of Viruses. Monographs in Virology, vol. 5. Karger, Basel, pp. 33–34.

    Not in our library

  125. 125.

    Wills J.W., Cameron C.E., Wilson C.B., Xiang Y., Bennett R.P., Leis J. An assembly domain of the Rous sarcoma virus Gag protein required late in budding. J. Virol. 1994;68:6605-6618.

    Not in our library10.1128/jvi.68.10.6605-6618.1994

  126. 126.

    Zeng M.-S., Li D.-J., Liu Q.-L., Song L.-B., Li M.-Z., Zhang R.-H., Yu X.-J., Wang H.-M., Ernberg I., Zeng Y.-X. Genomic sequence analysis of Epstein–Barr virus strain GD1 from a nasopharyngeal carcinoma patient. J. Virol. 2005;79:15323-15330.

    Not in our library10.1128/jvi.79.24.15323-15330.2005

  127. 127.

    Zimmermann W., Broll H., Ehlers B., Buhk H.-J., Rosenthal A., Goltz M. Genome sequence of bovine herpesvirus 4, a bovine Rhadinovirus, and identification of an origin of DNA replication. J. Virol. 2001;75:1186-1194.

    Not in our library10.1128/jvi.75.3.1186-1194.2001

  128. 128.

    Zhang Z., Rowe J., Wang W., Sommer M., Arvin A., Moffat J., Zhu H. Genetic analysis of varicella-zoster virus ORF0 to ORF4 using a novel luciferase bacterial artificial chromosome system. J. Virol. 2007;81:9024-9033.

    Not in our library10.1128/jvi.02666-06

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