Establishment of a human embryonic stem cell line with homozygous TP53 R248W mutant by TALEN mediated gene editing
An Xu, Ruoji Zhou, Jian Tu and 14 more
Stem Cell Research · 2018
doi:10.1016/j.scr.2018.04.013 (opens in a new tab)
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Abstract
Genetic mutations in TP53 contribute to multiple human cancers. Here we report the generation of a H1-p53(R248W/R248W) human embryonic stem cell line harboring a homozygous TP53 R248W mutation created by TALEN-mediated precise gene editing. The H1-p53(R248W/R248W) cell line maintains a normal karyotype, robust pluripotency gene expression, and the potential to differentiate to the three germ layers.
Abstract licence: CC BY-NC
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