A case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis
Yutaka Takahara, Kouichi Yamamura, Saki Matsuura and 12 more
Respiratory Medicine Case Reports · 2020
doi:10.1016/j.rmcr.2020.101124 (opens in a new tab)
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Abstract
A 53-year-old woman was referred to our hospital for detailed examination of abnormal chest shadows recognized on CT imaging. Transbronchial lung biopsy of a right S6 nodular shadow led to a diagnosis of lung adenocarcinoma. FDG-PET-CT showed FDG accumulation in the Th11 and L2 vertebral bodies and osteoblastic bone lesions. Since osteoblastic bone metastasis in lung cancer is extremely rare, CT-guided bone biopsy was performed. The tumor was diagnosed as ROS1-rearranged lung adenocarcinoma, for which crizotinib was administered, which led to improvement of both the primary and metastatic lesions. We report here a rare case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis of lung cancer.
Abstract licence: CC BY-NC
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