Mesenchymal stromal cells as a potential therapeutic for neurological disorders
Takeo Mukai, Arinobu Tojo, Tokiko Nagamura-Inoue
Regenerative Therapy · 2018
doi:10.1016/j.reth.2018.08.001 (opens in a new tab)
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Abstract
Several studies have reported that mesenchymal stromal/stem cells (MSCs) restore neurological damage through their secretion of paracrine factors or their differentiation to neuronal cells. Based on these studies, many clinical trials have been conducted using MSCs for neurological disorders, and their safety and efficacy have been reported. In this review, we provide a brief introduction to MSCs, especially umbilical cord derived-MSCs (UC-MSCs), in terms of characteristics, isolation, and cryopreservation, and discuss the recent progress in regenerative therapies using MSCs for various neurological disorders. Keywords: Mesenchymal stromal cell, Umbilical cord, Neurological disorders, Cerebral palsy, Neurotrophic factor
Abstract licence: CC BY-NC-ND
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