Fundus-controlled perimetry (microperimetry): Application as outcome measure in clinical trials

Abstract

Fundus-controlled perimetry (FCP, also called 'microperimetry') allows for spatially-resolved mapping of visual sensitivity and measurement of fixation stability, both in clinical practice as well as research. The accurate spatial characterization of visual function enabled by FCP can provide insightful information about disease severity and progression not reflected by best-corrected visual acuity in a large range of disorders. This is especially important for monitoring of retinal diseases that initially spare the central retina in earlier disease stages. Improved intra- and inter-session retest-variability through fundus-tracking and precise point-wise follow-up examinations even in patients with unstable fixation represent key advantages of these technique. The design of disease-specific test patterns and protocols reduces the burden of extensive and time-consuming FCP testing, permitting a more meaningful and focused application. Recent developments also allow for photoreceptor-specific testing through implementation of dark-adapted chromatic and photopic testing. A detailed understanding of the variety of available devices and test settings is a key prerequisite for the design and optimization of FCP protocols in future natural history studies and clinical trials. Accordingly, this review describes the theoretical and technical background of FCP, its prior application in clinical and research settings, data that qualify the application of FCP as an outcome measure in clinical trials as well as ongoing and future developments.

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References 295

1. 1.

   Alexander P, Mushtaq F, Osmond C, Amoaku W, 2012. Microperimetric changes in neovascular age-related macular degeneration treated with ranibizumab. Eye 26, 678–683..

   Not in our library10.1038/eye.2012.7

2. 2.

   Alonso-Plasencia M, Abreu-González R, Gómez-Culebras MA, 2019. Structure–function correlation using oct angiography and microperimetry in diabetic retinopathy. Clin. Ophthalmol 13, 2181–2188..

   Not in our library10.2147/opth.s220877

3. 3.

   Altpeter EK, Blanke BR, Leo-Kottler B, Nguyen XN, Trauzettel-Klosinski S, 2013. Evaluation of fixation pattern and reading ability in patients with Leber hereditary optic neuropathy. J. neuro-ophthalmology Off. J. North Am. Neuro-Ophthalmology Soc 33, 344–348..

   Not in our library10.1097/wno.0b013e31829d1f5b

4. 4.

   Amore FM, Fasciani R, Silvestri V, Crossland MD, de Waure C, Cruciani F, Reibaldi A, 2013. Relationship between fixation stability measured with MP-1 and reading performance. Ophthalmic Physiol. Optic 33, 611–617..

   Not in our library10.1111/opo.12048

5. 5.

   Anderson RS, 2006. The psychophysics of glaucoma: improving the structure/function relationship. Prog. Retin. Eye Res 25, 79–97..

   Not in our library10.1016/j.preteyeres.2005.06.001

6. 6.

   Artes PH, Iwase A, Ohno Y, Kitazawa Y, Chauhan BC, 2002. Properties of perimetric threshold estimates from full threshold, SITA standard, and SITA fast strategies. Invest. Ophthalmol. Vis. Sci 43, 2654–2659.

   Not in our library

7. 7.

   Foerster R, Aubert H, 1857. Untersuchungen über den Raumsinn der Retina. Arch. für Opthalmologie 3, 1–37..

   Not in our library10.1007/bf02720715

8. 8.

   Aulhorn E, Harms H, 2015. Early visual field defects in glaucoma, in: Glaucoma, pp. 151–186..

   Not in our library10.1159/000389404

9. 9.

   Aulhorn E, Harms H, Raabe M, 1966. Die lichtunterschiedsempfindlichkeit als funktion der umfeldleuchtdichte. Doc. Ophthalmol 20, 537–556..

   Not in our library10.1007/bf00165440

10. 10.

    Bach M, Schäfer K, 2016. Visual acuity testing: feedback affects neither outcome nor reproducibility, but leaves participants happier. PloS One 11. e0147803–e0147803.

    Not in our library10.1371/journal.pone.0147803

11. 11.

    Balasubramanian S, Uji A, Lei J, Velaga S, Nittala M, Sadda SV, 2017. Interdevice comparison of retinal sensitivity assessments in a healthy population: the CenterVue MAIA and the Nidek MP-3 microperimeters. Br. J. Ophthalmol 102, 109–113..

    Not in our library10.1136/bjophthalmol-2017-310258

12. 12.

    Barboni MTS, Szepessy Z, Ventura DF, Németh J, 2018. Individual test point fluctuations of macular sensitivity in healthy eyes and eyes with age-related macular degeneration measured with microperimetry. Transl. Vis. Sci. Technol 7, 25..

    Not in our library10.1167/tvst.7.2.25

13. 13.

    Barteselli G, Bartsch DU, Viola F, Mojana F, Pellegrini M, Hartmann KI, Benatti E, Leicht S, Ratiglia R, Staurenghi G, Weinreb RN, Freeman WR, 2013. Accuracy of the heidelberg spectralis in the alignment between near-infrared image and tomographic scan in a model eye: a multicenter study. Am. J. Ophthalmol 156, 588–592..

    Not in our library10.1016/j.ajo.2013.04.030

14. 14.

    Bellmann C, Feely M, Crossland MD, Kabanarou SA, Rubin GS, 2004. Fixation stability using central and pericentral fixation targets in patients with age-related macular degeneration. Ophthalmology 111, 2265–2270..

    Not in our library10.1016/j.ophtha.2004.06.019

15. 15.

    Bjerrum JP, 1889. Om en tilføjelse til den sædvanlige synsfeltundersøgelse samt om synsfeltet ved glaukom. Nord. Ophthalmol. Tidsskr 2, 141–185.

    Not in our library

16. 16.

    Bolz M, Simader C, Ritter M, Ahlers C, Benesch T, Prünte C, Schmidt-Erfurth U, 2010. Morphological and functional analysis of the loading regimen with intravitreal ranibizumab in neovascular age-related macular degeneration. Br. J. Ophthalmol 94, 185–189..

    Not in our library10.1136/bjo.2008.143974

17. 17.

    Bowl W, Lorenz B, Jäger M, Friedburg C, 2013. Improving detection of mild loss of retinal light increment sensitivity at the posterior pole with the Microperimeter MP1. Investig. Ophthalmol. Vis. Sci 54, 4666–4674..

    Not in our library10.1167/iovs.12-11241

18. 18.

    Buckley TMW, Jolly JK, Menghini M, Wood LJ, Nanda A, MacLaren RE, 2020. Test-retest repeatability of microperimetry in patients with retinitis pigmentosa caused by mutations in RPGR. Clin. Exp. Ophthalmol 48, 714–715..

    Not in our library10.1111/ceo.13753

19. 19.

    Burns SA, Webb TRH, 1995. Optical Generation of the Visual Stimulus. In: Handbook of Optics, Volume I, Fundamentals, Techniques, and Design. McGRAW-HILL, INC., pp. 28.1–28.28

    Not in our library

20. 20.

    Cassels NK, Wild JM, Margrain TH, Blyth C, Chong V, Acton JH, 2019. Microperimetry in age-related macular degeneration: an evidence-base for pattern deviation probability analysis in microperimetry. Transl. Vis. Sci. Technol 8, 48..

    Not in our library10.1167/tvst.8.6.48

21. 21.

    Cehajic-Kapetanovic J, Xue K, Martinez-Fernandez de la Camara C, Nanda A, Davies A, Wood LJ, Salvetti AP, Fischer MD, Aylward JW, Barnard AR, Jolly JK, Luo E, Lujan BJ, Ong T, Girach A, Black GCM, Gregori NZ, Davis JL, Rosa PR, Lotery AJ, Lam BL, Stanga PE, MacLaren RE, 2020. Initial results from a first-in-human gene therapy trial on X-linked retinitis pigmentosa caused by mutations in RPGR. Nat. Med 26, 354–359..

    Not in our library10.1038/s41591-020-0763-1

22. 22.

    Charbel Issa P, Helb HM, Rohrschneider K, Holz FG, Scholl HPN, 2007. Microperimetric assessment of patients with type 2 idiopathic macular telangiectasia. Investig. Ophthalmol. Vis. Sci 48, 3788–3795..

    Not in our library10.1167/iovs.06-1272

23. 23.

    Charbel Issa P, Gillies MC, Chew EY, Bird AC, Heeren TFC, Peto T, Holz FG, Scholl HPN, 2013. Macular telangiectasia type 2. Prog. Retin. Eye Res 34, 49–77..

    Not in our library10.1016/j.preteyeres.2012.11.002

24. 24.

    Charng J, Lamey TM, Thompson JA, McLaren TL, Attia MS, McAllister IL, Constable IJ, Mackey DA, De Roach JN, Chen FK, 2020a. Edge of scotoma sensitivity as a microperimetry clinical trial end point in USH2A retinopathy. Transl. Vis. Sci. Technol 9, 9..

    Not in our library10.1167/tvst.9.10.9

25. 25.

    Charng J, Sanfilippo PG, Attia MS, Dolliver M, Arunachalam S, Chew AL, Wong EN, Mackey DA, Chen FK, 2020b. Interpreting MAIA microperimetry using age- and retinal loci-specific reference thresholds. Transl. Vis. Sci. Technol 9, 19..

    Not in our library10.1167/tvst.9.7.19

26. 26.

    Chen FK, Patel PJ, Xing W, Bunce C, Egan C, Tufail AT, Coffey PJ, Rubin GS, da Cruz L, 2009. Test-retest variability of microperimetry using the Nidek MP1 in patients with macular disease. Investig. Ophthalmol. Vis. Sci 50, 3464–3472..

    Not in our library10.1167/iovs.08-2926

27. 27.

    Chen FK, Patel PJ, Webster AR, Coffey PJ, Tufail A, Da Cruz L, 2011. Nidek MP1 is able to detect subtle decline in function in inherited and age-related atrophic macular disease with stable visual acuity. Retina 31, 371–379..

    Not in our library10.1097/iae.0b013e3181e46af3

28. 28.

    Chen KG, Alvarez JA, Yazdanie M, Papudesu C, Wong WT, Wiley HE, Keenan TD, Chew EY, Ferris FL, Cukras CA, 2019. Longitudinal study of dark adaptation as a functional outcome measure for age-related macular degeneration. Ophthalmology 126, 856–865..

    Not in our library10.1016/j.ophtha.2018.09.039

29. 29.

    Chew EY, Clemons TE, Jaffe GJ, Johnson CA, Farsiu S, Lad EM, Guymer R, Rosenfeld P, Hubschman JP, Constable I, Wiley H, Singerman LJ, Gillies M, Comer G, Blodi B, Eliott D, Yan J, Bird A, Friedlander M, 2019. Effect of ciliary neurotrophic factor on retinal neurodegeneration in patients with macular telangiectasia type 2: a randomized clinical trial. Ophthalmology 126, 540–549..

    Not in our library10.1016/j.ophtha.2018.09.041

30. 30.

    Cideciyan AV, Swider M, Aleman TS, Sumaroka A, Schwartz SB, Roman MI, Milam AH, Bennett J, Stone EM, Jacobson SG, 2005. ABCA4-associated retinal degenerations spare structure and function of the human parapapillary retina. Investig. Ophthalmol. Vis. Sci 46, 4739–4746..

    Not in our library10.1167/iovs.05-0805

31. 31.

    Cideciyan AV, Aleman TS, Boye SL, Schwartz SB, Kaushal S, Roman AJ, Pang JJ, Sumaroka A, Windsor EAM, Wilson JM, Flotte TR, Fishman GA, Heon E, Stone EM, Byrne BJ, Jacobson SG, Hauswirth WW, 2008. Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics. Proc. Natl. Acad. Sci. U.S.A 105, 15112–15117..

    Not in our library10.1073/pnas.0807027105

32. 32.

    Cideciyan AV, Swider M, Aleman TS, Tsybovsky Y, Schwartz SB, Windsor EAM, Roman AJ, Sumaroka A, Steinberg JD, Jacobson SG, Stone EM, Palczewski K, 2009. ABCA4 disease progression and a proposed strategy for gene therapy. Hum. Mol. Genet 18, 931–941..

    Not in our library10.1093/hmg/ddn421

33. 33.

    Cideciyan AV, Swider M, Aleman TS, Feuer WJ, Schwartz SB, Russell RC, Steinberg JD, Stone EM, Jacobson SG, 2012. Macular function in macular degenerations: repeatability of microperimetry as a potential outcome measure for ABCA4-associated retinopathy trials. Investig. Ophthalmol. Vis. Sci 53, 841–852..

    Not in our library10.1167/iovs.11-8415

34. 34.

    Cideciyan AV, Roman AJ, Jacobson SG, Yan B, Pascolini M, Charng J, Pajaro S, Nirenberg S, 2016. Developing an outcome measure with high luminance for optogenetics treatment of severe retinal degenerations and for gene therapy of cone diseases. Investig. Ophthalmol. Vis. Sci 57, 3211–3221..

    Not in our library10.1167/iovs.16-19586

35. 35.

    Cocce KJ, Stinnett SS, Luhmann UFO, Vajzovic L, Horne A, Schuman SG, Toth CA, Cousins SW, Lad EM, 2018. Visual function metrics in early and intermediate dry age-related macular degeneration for use as clinical trial endpoints. Am. J. Ophthalmol 189, 127–138..

    Not in our library10.1016/j.ajo.2018.02.012

36. 36.

    Comyn O, Sivaprasad S, Peto T, Neveu MM, Holder GE, Xing W, Bunce CV, Patel PJ, Egan CA, Bainbridge JW, Hykin PG, 2014. A randomized trial to assess functional and structural effects of ranibizumab versus laser in diabetic macular edema (the LUCIDATE Study). Am. J. Ophthalmol 157, 960–970..

    Not in our library10.1016/j.ajo.2014.02.019

37. 37.

    Convento E, Midena E, Dorigo MT, Maritan V, Cavarzeran F, Fregona IA, 2006. Peripapillary fundus perimetry in eyes with glaucoma. Br. J. Ophthalmol 90, 1398–1403..

    Not in our library10.1136/bjo.2006.092973

38. 38.

    Corvi F, Pellegrini M, Belotti M, Bianchi C, Staurenghi G, 2019. Scotopic and fast mesopic microperimetry in eyes with drusen and reticular pseudodrusen. Retina 39, 2378–2383..

    Not in our library10.1097/iae.0000000000002335

39. 39.

    Crabb DP, Garway-Heath DF, 2012. Intervals between visual field tests when monitoring the glaucomatous patient: wait-and-see approach. Invest. Ophthalmol. Vis. Sci 53, 2770–2776..

    Not in our library10.1167/iovs.12-9476

40. 40.

    Crossland M, Rubin GS, 2014. Retinal fixation and microperimetry. In: Midena E (Ed.), Microperimetry and Multimodal Retinal Imaging. Springer Berlin Heidelberg, Berlin, Heidelberg, pp. 5–11..

    Not in our library10.1007/978-3-642-40300-2_2

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