HDAC inhibitors improve CRISPR-Cas9 mediated prime editing and base editing

(Molecular Therapy: Nucleic Acids 29, 36–46; September 2022) In the originally published version of this article, a statement of the co-first authorship was missed; Nan Liu, Lifang Zhou, and Guifeng Lin contributed equally to this work. This has been corrected online, and the authors regret this error. HDAC inhibitors improve CRISPR-Cas9 mediated prime editing and base editingLiu et al.Molecular Therapy - Nucleic AcidsJune 1, 2022In BriefCRISPR-Cas9-derived prime editors and base editors are powerful tools in precise genome editing. We demonstrate that HDAC inhibition increases the efficiency of prime editors and base editors, which advances our understanding of regulating endogenous mechanisms to improve genome editing. Full-Text PDF Open Access

Abstract licence: CC BY-NC

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