Skip to content
naulon

No retraction, correction or concern found when last checked on Nov 4, 2026.

Medial and orbital frontal cortex in decision-making and flexible behavior

Miriam C. Klein-Flügge, Alessandro Bongioanni, Matthew F.S. Rushworth

Neuron · 2022 · Review

doi:10.1016/j.neuron.2022.05.022

References 247

  1. 1.

    Abitbol R, Lebreton M, Hollard G, Richmond BJ, Bouret S, Pessiglione M. Neural mechanisms underlying contextual dependency of subjective values: converging evidence from monkeys and humans. J Neurosci. 2015;35:2308-2320.

    Not in our library10.1523/jneurosci.1878-14.2015

  2. 2.

    Agetsuma M, Aizawa H, Aoki T, Nakayama R, Takahoko M, Goto M, Sassa T, Amo R, Shiraki T, Kawakami K, et al. The habenula is crucial for experience-dependent modification of fear responses in zebrafish. Nat Neurosci. 2010;13:1354-1356.

    Not in our library10.1038/nn.2654

  3. 3.

    Amemori K, Graybiel AM. Localized microstimulation of primate pregenual cingulate cortex induces negative decision-making. Nat Neurosci. 2012;15:776-785.

    Not in our library10.1038/nn.3088

  4. 4.

    Amemori S, Graybiel AM, Amemori K. Causal Evidence for Induction of Pessimistic Decision-Making in Primates by the Network of Frontal Cortex and Striosomes. Front Neurosci. 2021;15:741.

    Not in our library10.3389/fnins.2021.649167

  5. 5.

    Amo R, Fredes F, Kinoshita M, Aoki R, Aizawa H, Agetsuma M, Aoki T, Shiraki T, Kakinuma H, Matsuda M, et al. The habenulo-raphe serotonergic circuit encodes an aversive expectation value essential for adaptive active avoidance of danger. Neuron. 2014;84:1034-1048.

    Not in our library10.1016/j.neuron.2014.10.035

  6. 6.

    An X, Bandler R, Ongur D, Price JL. Prefrontal cortical projections to longitudinal columns in the midbrain periaqueductal gray in macaque monkeys. J Comp Neurol. 1998;401:455-479.

    Not in our library

  7. 7.

    Ashwell KWS, McAllan BM, Mai JK, Paxinos G. Cortical cyto- and chemoarchitecture in three small Australian marsupial carnivores: Sminthopsis macroura, Antechinus stuartii and Phascogale calura. Brain Behav Evol. 2008;72:215-232.

    Not in our library10.1159/000165101

  8. 8.

    Badre D, Doll BB, Long NM, Frank MJ. Rostrolateral prefrontal cortex and individual differences in uncertainty-driven exploration. Neuron. 2012;73:595-607.

    Not in our library10.1016/j.neuron.2011.12.025

  9. 9.

    Ballesta S, Shi W, Conen KE, Padoa-Schioppa C. Values encoded in orbitofrontal cortex are causally related to economic choices. Nature. 2020;588:450-453.

    Not in our library10.1038/s41586-020-2880-x

  10. 10.

    Banerjee A, Parente G, Teutsch J, Lewis C, Voigt FF, Helmchen F. Value-guided remapping of sensory cortex by lateral orbitofrontal cortex. Nature. 2020;585:245-250.

    Not in our library10.1038/s41586-020-2704-z

  11. 11.

    Bang D, Fleming SM. Distinct encoding of decision confidence in human medial prefrontal cortex. Proc Natl Acad Sci. 2018;115:6082-6087.

    Not in our library10.1073/pnas.1800795115

  12. 12.

    Bao X, Gjorgieva E, Shanahan LK, Howard JD, Kahnt T, Gottfried JA. Grid-like Neural Representations Support Olfactory Navigation of a Two-Dimensional Odor Space. Neuron. 2019;102:1066-1075.

    Not in our library10.1016/j.neuron.2019.03.034

  13. 13.

    Barack DL, Platt ML. Neuronal Activity in the Posterior Cingulate Cortex Signals Environmental Information and Predicts Behavioral Variability during Trapline Foraging. J Neurosci Off J Soc Neurosci. 2021;41:2703-2712.

    Not in our library10.1523/jneurosci.0305-20.2020

  14. 14.

    Barack DL, Chang SWC, Platt ML. Posterior Cingulate Neurons Dynamically Signal Decisions to Disengage during Foraging. Neuron. 2017;96:339-347.

    Not in our library10.1016/j.neuron.2017.09.048

  15. 15.

    Baram AB, Muller TH, Nili H, Garvert MM, Behrens TEJ. Entorhinal and ventromedial prefrontal cortices abstract and generalize the structure of reinforcement learning problems. Neuron. 2021;109:713-723.

    Not in our library10.1016/j.neuron.2020.11.024

  16. 16.

    Barron HC, Dolan RJ, Behrens TE. Online evaluation of novel choices by simultaneous representation of multiple memories. Nat Neurosci. 2013;16:1492-1498.

    Not in our library10.1038/nn.3515

  17. 17.

    Bartolo R, Averbeck BB. Prefrontal Cortex Predicts State Switches during Reversal Learning. Neuron. 2020;106:1044-1054.

    Not in our library10.1016/j.neuron.2020.03.024

  18. 18.

    Bartra O, McGuire JT, Kable JW. The valuation system: a coordinate-based meta-analysis of BOLD fMRI experiments examining neural correlates of subjective value. Neuroimage. 2013;76:412-427.

    Not in our library10.1016/j.neuroimage.2013.02.063

  19. 19.

    Behrens TE, Woolrich MW, Walton ME, Rushworth MF. Learning the value of information in an uncertain world. Nat Neurosci. 2007;10:1214-1221.

    Not in our library10.1038/nn1954

  20. 20.

    Behrens TE, Hunt LT, Woolrich MW, Rushworth MF. Associative learning of social value. Nature. 2008;456:245-249.

    Not in our library10.1038/nature07538

  21. 21.

    Behrens TEJ, Muller TH, Whittington JCR, Mark S, Baram AB, Stachenfeld KL, Kurth-Nelson Z. What Is a Cognitive Map? Organizing Knowledge for Flexible Behavior. Neuron. 2018;100:490-509.

    Not in our library10.1016/j.neuron.2018.10.002

  22. 22.

    Bernacchia A, Seo H, Lee D, Wang XJ. A reservoir of time constants for memory traces in cortical neurons. Nat Neurosci. 2011;14:366-372.

    Not in our library10.1038/nn.2752

  23. 23.

    Blanchard TC, Hayden BY. Neurons in dorsal anterior cingulate cortex signal postdecisional variables in a foraging task. J Neurosci. 2014;34:646-655.

    Not in our library10.1523/jneurosci.3151-13.2014

  24. 24.

    Bongioanni A, Folloni D, Verhagen L, Sallet J, Klein-Flügge MC, Rushworth MFS. Activation and disruption of a neural mechanism for novel choice in monkeys. Nature. 2021;591:270-274.

    Not in our library10.1038/s41586-020-03115-5

  25. 25.
  26. 26.

    Boorman ED, Behrens TE, Woolrich MW, Rushworth MF. How green is the grass on the other side? Frontopolar cortex and the evidence in favor of alternative courses of action. Neuron. 2009;62:733-743.

    Not in our library10.1016/j.neuron.2009.05.014

  27. 27.

    Boorman ED, Rushworth MF, Behrens T. Ventromedial prefrontal and anterior cingulate cortex adopt choice and default reference frames during sequential multialternative choice. J Neurosci. 2013;33:2242-2253.

    Not in our library10.1523/jneurosci.3022-12.2013

  28. 28.

    Boorman ED, Rajendran VG, O’Reilly JX, Behrens TE. Two Anatomically and Computationally Distinct Learning Signals Predict Changes to Stimulus-Outcome Associations in Hippocampus. Neuron. 2016;89:1343-1354.

    Not in our library10.1016/j.neuron.2016.02.014

  29. 29.

    Bromberg-Martin ES, Hikosaka O. Midbrain dopamine neurons signal preference for advance information about upcoming rewards. Neuron. 2009;63:119-126.

    Not in our library10.1016/j.neuron.2009.06.009

  30. 30.

    Burke CJ, Brünger C, Kahnt T, Park SQ, Tobler PN. Neural integration of risk and effort costs by the frontal pole: only upon request. J Neurosci Off J Soc Neurosci. 2013;33:1706-1713a.

    Not in our library10.1523/jneurosci.3662-12.2013

  31. 31.
  32. 32.

    Cai X, Padoa-Schioppa C. Contributions of orbitofrontal and lateral prefrontal cortices to economic choice and the good-to-action transformation. Neuron. 2014;81:1140-1151.

    Not in our library10.1016/j.neuron.2014.01.008

  33. 33.

    Camille N, Griffiths CA, Vo K, Fellows LK, Kable JW. Ventromedial frontal lobe damage disrupts value maximization in humans. J Neurosci. 2011;31:7527-7532.

    Not in our library10.1523/jneurosci.6527-10.2011

  34. 34.

    Cavanagh SE, Wallis JD, Kennerley SW, Hunt LT. Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice. ELife. 2016;5:e18937.

    Not in our library10.7554/elife.18937

  35. 35.

    Charnov EL. Optimal foraging: the marginal value theorem. Theor Popul Biol. 1976;9:129-136.

    Not in our library10.1016/0040-5809(76)90040-x

  36. 36.

    Chau BK, Kolling N, Hunt LT, Walton ME, Rushworth MF. A neural mechanism underlying failure of optimal choice with multiple alternatives. Nat Neurosci. 2014;17:463-470.

    Not in our library10.1038/nn.3649

  37. 37.
  38. 38.

    Chau BK, Law C-K, Lopez-Persem A, Klein-Flügge MC, Rushworth MF. Consistent patterns of distractor effects during decision making. ELife. 2020;9:e53850.

    Not in our library10.7554/elife.53850

  39. 39.

    Chen D, Kunz L, Lv P, Zhang H, Zhou W, Liang S, Axmacher N, Wang L. Theta oscillations coordinate grid-like representations between ventromedial prefrontal and entorhinal cortex. Sci Adv. 2021;7:eabj0200.

    Not in our library10.1126/sciadv.abj0200

  40. 40.

    Chiba T, Kayahara T, Nakano K. Efferent projections of infralimbic and prelimbic areas of the medial prefrontal cortex in the Japanese monkey, Macaca fuscata. Brain Res. 2001;888:83-101.

    Not in our library10.1016/s0006-8993(00)03013-4

All 247 references

Cited by papers we hold 1

Reads

Read by people on this page

None yet.

Checked or read by AI through naulon

None yet.

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.

Are you an author?

Is this your paper?

Claim it to add your note and be paid when agents cite it. Free.