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CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation

Silvia De Rubeis, Emanuela Pasciuto, Ka Wan Li and 14 more (opens in a new tab)

Neuron · 2013 · CC BY-NC-ND

doi:10.1016/j.neuron.2013.06.039 (opens in a new tab)

Abstract

The CYFIP1/SRA1 gene is located in a chromosomal region linked to various neurological disorders, including intellectual disability, autism, and schizophrenia. CYFIP1 plays a dual role in two apparently unrelated processes, inhibiting local protein synthesis and favoring actin remodeling. Here, we show that brain-derived neurotrophic factor (BDNF)-driven synaptic signaling releases CYFIP1 from the translational inhibitory complex, triggering translation of target mRNAs and shifting CYFIP1 into the WAVE regulatory complex. Active Rac1 alters the CYFIP1 conformation, as demonstrated by intramolecular FRET, and is key in changing the equilibrium of the two complexes. CYFIP1 thus orchestrates the two molecular cascades, protein translation and actin polymerization, each of which is necessary for correct spine morphology in neurons. The CYFIP1 interactome reveals many interactors associated with brain disorders, opening new perspectives to define regulatory pathways shared by neurological disabilities characterized by spine dysmorphogenesis.

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References 80

  1. 1.

    Aakalu G., Smith W.B., Nguyen N., Jiang C., Schuman E.M. Dynamic visualization of local protein synthesis in hippocampal neurons. Neuron. 2001;30:489-502.

    Not in our library10.1016/s0896-6273(01)00295-1 (opens in a new tab)

  2. 2.

    Albertazzi L., Arosio D., Marchetti L., Ricci F., Beltram F. Quantitative FRET analysis with the EGFP-mCherry fluorescent protein pair. Photochem. Photobiol. 2009;85:287-297.

    Not in our library10.1111/j.1751-1097.2008.00435.x (opens in a new tab)

  3. 3.

    Bagni C., Tassone F., Neri G., Hagerman R. Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics. J. Clin. Invest. 2012;122:4314-4322.

    Not in our library10.1172/jci63141 (opens in a new tab)

  4. 4.

    Bassell G.J., Warren S.T. Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function. Neuron. 2008;60:201-214.

    Not in our library10.1016/j.neuron.2008.10.004 (opens in a new tab)

  5. 5.

    Bear M.F., Huber K.M., Warren S.T. The mGluR theory of fragile X mental retardation. Trends Neurosci. 2004;27:370-377.

    Not in our library10.1016/j.tins.2004.04.009 (opens in a new tab)

  6. 6.

    Belmonte M.K., Bourgeron T. Fragile X syndrome and autism at the intersection of genetic and neural networks. Nat. Neurosci. 2006;9:1221-1225.

    Not in our library10.1038/nn1765 (opens in a new tab)

  7. 7.

    Bozdagi O., Sakurai T., Dorr N., Pilorge M., Takahashi N., Buxbaum J.D. Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in mice. PLoS ONE. 2012;7:e42422.

    Not in our library10.1371/journal.pone.0042422 (opens in a new tab)

  8. 8.

    Bramham C.R. Local protein synthesis, actin dynamics, and LTP consolidation. Curr. Opin. Neurobiol. 2008;18:524-531.

    Not in our library10.1016/j.conb.2008.09.013 (opens in a new tab)

  9. 9.

    Brown V., Jin P., Ceman S., Darnell J.C., O’Donnell W.T., Tenenbaum S.A., Jin X., Feng Y., Wilkinson K.D., Keene J.D. Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. Cell. 2001;107:477-487.

    Not in our library10.1016/s0092-8674(01)00568-2 (opens in a new tab)

  10. 10.

    Castets M., Schaeffer C., Bechara E., Schenck A., Khandjian E.W., Luche S., Moine H., Rabilloud T., Mandel J.L., Bardoni B. FMRP interferes with the Rac1 pathway and controls actin cytoskeleton dynamics in murine fibroblasts. Hum. Mol. Genet. 2005;14:835-844.

    Not in our library10.1093/hmg/ddi077 (opens in a new tab)

  11. 11.

    Chen C., Okayama H. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 1987;7:2745-2752.

    Not in our library10.1128/mcb.7.8.2745-2752.1987 (opens in a new tab)

  12. 12.

    Chen Z., Borek D., Padrick S.B., Gomez T.S., Metlagel Z., Ismail A.M., Umetani J., Billadeau D.D., Otwinowski Z., Rosen M.K. Structure and control of the actin regulatory WAVE complex. Nature. 2010;468:533-538.

    Not in our library10.1038/nature09623 (opens in a new tab)

  13. 13.

    Comery T.A., Harris J.B., Willems P.J., Oostra B.A., Irwin S.A., Weiler I.J., Greenough W.T. Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits. Proc. Natl. Acad. Sci. USA. 1997;94:5401-5404.

    Not in our library10.1073/pnas.94.10.5401 (opens in a new tab)

  14. 14.

    Cooper G.M., Coe B.P., Girirajan S., Rosenfeld J.A., Vu T.H., Baker C., Williams C., Stalker H., Hamid R., Hannig V. A copy number variation morbidity map of developmental delay. Nat. Genet. 2011;43:838-846.

    Not in our library10.1038/ng.909 (opens in a new tab)

  15. 15.

    Costa-Mattioli M., Sossin W.S., Klann E., Sonenberg N. Translational control of long-lasting synaptic plasticity and memory. Neuron. 2009;61:10-26.

    Not in our library10.1016/j.neuron.2008.10.055 (opens in a new tab)

  16. 16.

    Cruz-Martín A., Crespo M., Portera-Cailliau C. Delayed stabilization of dendritic spines in fragile X mice. J. Neurosci. 2010;30:7793-7803.

    Not in our library10.1523/jneurosci.0577-10.2010 (opens in a new tab)

  17. 17.

    Darnell J.C., Van Driesche S.J., Zhang C., Hung K.Y., Mele A., Fraser C.E., Stone E.F., Chen C., Fak J.J., Chi S.W. FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism. Cell. 2011;146:247-261.

    Not in our library10.1016/j.cell.2011.06.013 (opens in a new tab)

  18. 18.

    Dictenberg J.B., Swanger S.A., Antar L.N., Singer R.H., Bassell G.J. A direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome. Dev. Cell. 2008;14:926-939.

    Not in our library10.1016/j.devcel.2008.04.003 (opens in a new tab)

  19. 19.

    Doornbos M., Sikkema-Raddatz B., Ruijvenkamp C.A., Dijkhuizen T., Bijlsma E.K., Gijsbers A.C., Hilhorst-Hofstee Y., Hordijk R., Verbruggen K.T., Kerstjens-Frederikse W.S. Nine patients with a microdeletion 15q11.2 between breakpoints 1 and 2 of the Prader-Willi critical region, possibly associated with behavioural disturbances. Eur. J. Med. Genet. 2009;52:108-115.

    Not in our library10.1016/j.ejmg.2009.03.010 (opens in a new tab)

  20. 20.

    Eden S., Rohatgi R., Podtelejnikov A.V., Mann M., Kirschner M.W. Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature. 2002;418:790-793.

    Not in our library10.1038/nature00859 (opens in a new tab)

  21. 21.

    Ehninger D., Silva A.J. Genetics and neuropsychiatric disorders: treatment during adulthood. Nat. Med. 2009;15:849-850.

    Not in our library10.1038/nm0809-849 (opens in a new tab)

  22. 22.

    Farzin F., Perry H., Hessl D., Loesch D., Cohen J., Bacalman S., Gane L., Tassone F., Hagerman P., Hagerman R. Autism spectrum disorders and attention-deficit/hyperactivity disorder in boys with the fragile X premutation. J. Dev. Behav. Pediatr. 2006;27(2, Suppl):S137-S144.

    Not in our library10.1097/00004703-200604002-00012 (opens in a new tab)

  23. 23.

    Ferrari F., Mercaldo V., Piccoli G., Sala C., Cannata S., Achsel T., Bagni C. The fragile X mental retardation protein-RNP granules show an mGluR-dependent localization in the post-synaptic spines. Mol. Cell. Neurosci. 2007;34:343-354.

    Not in our library10.1016/j.mcn.2006.11.015 (opens in a new tab)

  24. 24.

    Fiala J.C., Spacek J., Harris K.M. Dendritic spine pathology: cause or consequence of neurological disorders? Brain Res. Brain Res. Rev. 2002;39:29-54.

    Not in our library10.1016/s0165-0173(02)00158-3 (opens in a new tab)

  25. 25.

    Galvez R., Greenough W.T. Sequence of abnormal dendritic spine development in primary somatosensory cortex of a mouse model of the fragile X mental retardation syndrome. Am. J. Med. Genet. A. 2005;135:155-160.

    Not in our library10.1002/ajmg.a.30709 (opens in a new tab)

  26. 26.

    Gao Y., Dickerson J.B., Guo F., Zheng J., Zheng Y. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc. Natl. Acad. Sci. USA. 2004;101:7618-7623.

    Not in our library10.1073/pnas.0307512101 (opens in a new tab)

  27. 27.

    Gingras A.C., Raught B., Sonenberg N. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu. Rev. Biochem. 1999;68:913-963.

    Not in our library10.1146/annurev.biochem.68.1.913 (opens in a new tab)

  28. 28.

    Grove M., Demyanenko G., Echarri A., Zipfel P.A., Quiroz M.E., Rodriguiz R.M., Playford M., Martensen S.A., Robinson M.R., Wetsel W.C. ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory. Mol. Cell. Biol. 2004;24:10905-10922.

    Not in our library10.1128/mcb.24.24.10905-10922.2004 (opens in a new tab)

  29. 29.

    Hatton D.D., Sideris J., Skinner M., Mankowski J., Bailey D.B., Roberts J., Mirrett P. Autistic behavior in children with fragile X syndrome: prevalence, stability, and the impact of FMRP. Am. J. Med. Genet. A. 2006;140A:1804-1813.

    Not in our library10.1002/ajmg.a.31286 (opens in a new tab)

  30. 30.

    Iossifov I., Ronemus M., Levy D., Wang Z., Hakker I., Rosenbaum J., Yamrom B., Lee Y.H., Narzisi G., Leotta A. De novo gene disruptions in children on the autistic spectrum. Neuron. 2012;74:285-299.

    Not in our library10.1016/j.neuron.2012.04.009 (opens in a new tab)

  31. 31.

    Irwin S.A., Patel B., Idupulapati M., Harris J.B., Crisostomo R.A., Larsen B.P., Kooy F., Willems P.J., Cras P., Kozlowski P.B. Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: a quantitative examination. Am. J. Med. Genet. 2001;98:161-167.

    Not in our library10.1002/1096-8628(20010115)98:2<161::aid-ajmg1025>3.0.co;2-b (opens in a new tab)

  32. 32.

    Irwin S.A., Idupulapati M., Gilbert M.E., Harris J.B., Chakravarti A.B., Rogers E.J., Crisostomo R.A., Larsen B.P., Mehta A., Alcantara C.J. Dendritic spine and dendritic field characteristics of layer V pyramidal neurons in the visual cortex of fragile-X knockout mice. Am. J. Med. Genet. 2002;111:140-146.

    Not in our library10.1002/ajmg.10500 (opens in a new tab)

  33. 33.

    Jacquemont S., Hagerman R.J., Hagerman P.J., Leehey M.A. Fragile-X syndrome and fragile X-associated tremor/ataxia syndrome: two faces of FMR1. Lancet Neurol. 2007;6:45-55.

    Not in our library10.1016/s1474-4422(06)70676-7 (opens in a new tab)

  34. 34.

    Kim Y., Sung J.Y., Ceglia I., Lee K.W., Ahn J.H., Halford J.M., Kim A.M., Kwak S.P., Park J.B., Ho Ryu S. Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology. Nature. 2006;442:814-817.

    Not in our library10.1038/nature04976 (opens in a new tab)

  35. 35.

    Klemmer P., Meredith R.M., Holmgren C.D., Klychnikov O.I., Stahl-Zeng J., Loos M., van der Schors R.C., Wortel J., de Wit H., Spijker S. Proteomics, ultrastructure, and physiology of hippocampal synapses in a fragile X syndrome mouse model reveal presynaptic phenotype. J. Biol. Chem. 2011;286:25495-25504.

    Not in our library10.1074/jbc.m110.210260 (opens in a new tab)

  36. 36.

    Kobayashi K., Kuroda S., Fukata M., Nakamura T., Nagase T., Nomura N., Matsuura Y., Yoshida-Kubomura N., Iwamatsu A., Kaibuchi K. p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase. J. Biol. Chem. 1998;273:291-295.

    Not in our library10.1074/jbc.273.1.291 (opens in a new tab)

  37. 37.

    Lebensohn A.M., Kirschner M.W. Activation of the WAVE complex by coincident signals controls actin assembly. Mol. Cell. 2009;36:512-524.

    Not in our library10.1016/j.molcel.2009.10.024 (opens in a new tab)

  38. 38.
    Genetic and Functional Analyses of SHANK2 Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders · 2012
    No notice
  39. 39.

    Liao L., Park S.K., Xu T., Vanderklish P., Yates J.R. Quantitative proteomic analysis of primary neurons reveals diverse changes in synaptic protein content in fmr1 knockout mice. Proc. Natl. Acad. Sci. USA. 2008;105:15281-15286.

    Not in our library10.1073/pnas.0804678105 (opens in a new tab)

  40. 40.

    Miyashiro K.Y., Beckel-Mitchener A., Purk T.P., Becker K.G., Barret T., Liu L., Carbonetto S., Weiler I.J., Greenough W.T., Eberwine J. RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice. Neuron. 2003;37:417-431.

    Not in our library10.1016/s0896-6273(03)00034-5 (opens in a new tab)

  41. 41.

    Murthy S.K., Nygren A.O., El Shakankiry H.M., Schouten J.P., Al Khayat A.I., Ridha A., Al Ali M.T. Detection of a novel familial deletion of four genes between BP1 and BP2 of the Prader-Willi/Angelman syndrome critical region by oligo-array CGH in a child with neurological disorder and speech impairment. Cytogenet. Genome Res. 2007;116:135-140.

    Not in our library10.1159/000097433 (opens in a new tab)

  42. 42.

    Naldini L., Blömer U., Gallay P., Ory D., Mulligan R., Gage F.H., Verma I.M., Trono D. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science. 1996;272:263-267.

    Not in our library10.1126/science.272.5259.263 (opens in a new tab)

  43. 43.

    Napoli I., Mercaldo V., Boyl P.P., Eleuteri B., Zalfa F., De Rubeis S., Di Marino D., Mohr E., Massimi M., Falconi M. The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell. 2008;134:1042-1054.

    Not in our library10.1016/j.cell.2008.07.031 (opens in a new tab)

  44. 44.

    Neves-Pereira M., Müller B., Massie D., Williams J.H., O’Brien P.C., Hughes A., Shen S.B., Clair D.S., Miedzybrodzka Z. Deregulation of EIF4E: a novel mechanism for autism. J. Med. Genet. 2009;46:759-765.

    Not in our library10.1136/jmg.2009.066852 (opens in a new tab)

  45. 45.

    Niere F., Wilkerson J.R., Huber K.M. Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression. J. Neurosci. 2012;32:5924-5936.

    Not in our library10.1523/jneurosci.4650-11.2012 (opens in a new tab)

  46. 46.

    Nishimura Y., Martin C.L., Vazquez-Lopez A., Spence S.J., Alvarez-Retuerto A.I., Sigman M., Steindler C., Pellegrini S., Schanen N.C., Warren S.T., Geschwind D.H. Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways. Hum. Mol. Genet. 2007;16:1682-1698.

    Not in our library10.1093/hmg/ddm116 (opens in a new tab)

  47. 47.

    Nowicki S.T., Tassone F., Ono M.Y., Ferranti J., Croquette M.F., Goodlin-Jones B., Hagerman R.J. The Prader-Willi phenotype of fragile X syndrome. J. Dev. Behav. Pediatr. 2007;28:133-138.

    Not in our library10.1097/01.dbp.0000267563.18952.c9 (opens in a new tab)

  48. 48.

    Papa M., Bundman M.C., Greenberger V., Segal M. Morphological analysis of dendritic spine development in primary cultures of hippocampal neurons. J. Neurosci. 1995;15:1-11.

    Not in our library10.1523/jneurosci.15-01-00001.1995 (opens in a new tab)

  49. 49.

    Park S., Park J.M., Kim S., Kim J.A., Shepherd J.D., Smith-Hicks C.L., Chowdhury S., Kaufmann W., Kuhl D., Ryazanov A.G. Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. Neuron. 2008;59:70-83.

    Not in our library10.1016/j.neuron.2008.05.023 (opens in a new tab)

  50. 50.

    Peebles C.L., Yoo J., Thwin M.T., Palop J.J., Noebels J.L., Finkbeiner S. Arc regulates spine morphology and maintains network stability in vivo. Proc. Natl. Acad. Sci. USA. 2010;107:18173-18178.

    Not in our library10.1073/pnas.1006546107 (opens in a new tab)

  51. 51.

    Penzes P., Cahill M.E., Jones K.A., VanLeeuwen J.E., Woolfrey K.M. Dendritic spine pathology in neuropsychiatric disorders. Nat. Neurosci. 2011;14:285-293.

    Not in our library10.1038/nn.2741 (opens in a new tab)

  52. 52.

    Petroulakis E., Wang E. Nerve growth factor specifically stimulates translation of eukaryotic elongation factor 1A-1 (eEF1A-1) mRNA by recruitment to polyribosomes in PC12 cells. J. Biol. Chem. 2002;277:18718-18727.

    Not in our library10.1074/jbc.m111782200 (opens in a new tab)

  53. 53.

    Phillips G.R., Huang J.K., Wang Y., Tanaka H., Shapiro L., Zhang W., Shan W.S., Arndt K., Frank M., Gordon R.E. The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitution. Neuron. 2001;32:63-77.

    Not in our library10.1016/s0896-6273(01)00450-0 (opens in a new tab)

  54. 54.

    Reiss A.L., Feinstein C., Toomey K.E., Goldsmith B., Rosenbaum K., Caruso M.A. Psychiatric disability associated with the fragile X chromosome. Am. J. Med. Genet. 1986;23:393-401.

    Not in our library10.1002/ajmg.1320230131 (opens in a new tab)

  55. 55.

    Richter J.D., Klann E. Making synaptic plasticity and memory last: mechanisms of translational regulation. Genes Dev. 2009;23:1-11.

    Not in our library10.1101/gad.1735809 (opens in a new tab)

  56. 56.

    Ripke S., Sanders A.R., Kendler K.S., Levinson D.F., Sklar P., Holmans P.A., Lin D.Y., Duan J., Ophoff R.A., Andreassen O.A., Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium. Genome-wide association study identifies five new schizophrenia loci. Nat. Genet. 2011;43:969-976.

    Not in our library10.1038/ng.940 (opens in a new tab)

  57. 57.

    Sahoo T., Peters S.U., Madduri N.S., Glaze D.G., German J.R., Bird L.M., Barbieri-Welge R., Bichell T.J., Beaudet A.L., Bacino C.A. Microarray based comparative genomic hybridization testing in deletion bearing patients with Angelman syndrome: genotype-phenotype correlations. J. Med. Genet. 2006;43:512-516.

    Not in our library10.1136/jmg.2005.036913 (opens in a new tab)

  58. 58.

    Sans N., Prybylowski K., Petralia R.S., Chang K., Wang Y.X., Racca C., Vicini S., Wenthold R.J. NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. Nat. Cell Biol. 2003;5:520-530.

    Not in our library10.1038/ncb990 (opens in a new tab)

  59. 59.

    Schenck A., Bardoni B., Moro A., Bagni C., Mandel J.L. A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P. Proc. Natl. Acad. Sci. USA. 2001;98:8844-8849.

    Not in our library10.1073/pnas.151231598 (opens in a new tab)

  60. 60.

    Schenck A., Bardoni B., Langmann C., Harden N., Mandel J.L., Giangrande A. CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein. Neuron. 2003;38:887-898.

    Not in our library10.1016/s0896-6273(03)00354-4 (opens in a new tab)

  61. 61.

    Schratt G.M., Nigh E.A., Chen W.G., Hu L., Greenberg M.E. BDNF regulates the translation of a select group of mRNAs by a mammalian target of rapamycin-phosphatidylinositol 3-kinase-dependent pathway during neuronal development. J. Neurosci. 2004;24:7366-7377.

    Not in our library10.1523/jneurosci.1739-04.2004 (opens in a new tab)

  62. 62.

    Shepherd J.D., Bear M.F. New views of Arc, a master regulator of synaptic plasticity. Nat. Neurosci. 2011;14:279-284.

    Not in our library10.1038/nn.2708 (opens in a new tab)

  63. 63.

    Soderling S.H., Guire E.S., Kaech S., White J., Zhang F., Schutz K., Langeberg L.K., Banker G., Raber J., Scott J.D. A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory. J. Neurosci. 2007;27:355-365.

    Not in our library10.1523/jneurosci.3209-06.2006 (opens in a new tab)

  64. 64.

    Sonenberg N., Hinnebusch A.G. Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell. 2009;136:731-745.

    Not in our library10.1016/j.cell.2009.01.042 (opens in a new tab)

  65. 65.

    Steffen A., Rottner K., Ehinger J., Innocenti M., Scita G., Wehland J., Stradal T.E. Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation. EMBO J. 2004;23:749-759.

    Not in our library10.1038/sj.emboj.7600084 (opens in a new tab)

  66. 66.

    Tada T., Sheng M. Molecular mechanisms of dendritic spine morphogenesis. Curr. Opin. Neurobiol. 2006;16:95-101.

    Not in our library10.1016/j.conb.2005.12.001 (opens in a new tab)

  67. 67.

    Takei N., Inamura N., Kawamura M., Namba H., Hara K., Yonezawa K., Nawa H. Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites. J. Neurosci. 2004;24:9760-9769.

    Not in our library10.1523/jneurosci.1427-04.2004 (opens in a new tab)

  68. 68.

    Takenawa T., Suetsugu S. The WASP-WAVE protein network: connecting the membrane to the cytoskeleton. Nat. Rev. Mol. Cell Biol. 2007;8:37-48.

    Not in our library10.1038/nrm2069 (opens in a new tab)

  69. 69.

    Tam G.W., van de Lagemaat L.N., Redon R., Strathdee K.E., Croning M.D., Malloy M.P., Muir W.J., Pickard B.S., Deary I.J., Blackwood D.H. Confirmed rare copy number variants implicate novel genes in schizophrenia. Biochem. Soc. Trans. 2010;38:445-451.

    Not in our library10.1042/bst0380445 (opens in a new tab)

  70. 70.

    Tashiro A., Yuste R. Regulation of dendritic spine motility and stability by Rac1 and Rho kinase: evidence for two forms of spine motility. Mol. Cell. Neurosci. 2004;26:429-440.

    Not in our library10.1016/j.mcn.2004.04.001 (opens in a new tab)

  71. 71.

    Turk J. Fragile X syndrome: lifespan developmental implications for those without as well as with intellectual disability. Curr. Opin. Psychiatry. 2011;24:387-397.

    Not in our library10.1097/yco.0b013e328349bb77 (opens in a new tab)

  72. 72.

    Valnegri P., Sala C., Passafaro M. Synaptic dysfunction and intellectual disability. Adv. Exp. Med. Biol. 2012;970:433-449.

    Not in our library10.1007/978-3-7091-0932-8_19 (opens in a new tab)

  73. 73.

    van der Zwaag B., Staal W.G., Hochstenbach R., Poot M., Spierenburg H.A., de Jonge M.V., Verbeek N.E., van ’t Slot R., van Es M.A., Staal F.J. A co-segregating microduplication of chromosome 15q11.2 pinpoints two risk genes for autism spectrum disorder. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 2010;153B:960-966.

    Not in our library10.1002/ajmg.b.31055 (opens in a new tab)

  74. 74.

    Vidal M., Cusick M.E., Barabási A.L. Interactome networks and human disease. Cell. 2011;144:986-998.

    Not in our library10.1016/j.cell.2011.02.016 (opens in a new tab)

  75. 75.

    von der Lippe C., Rustad C., Heimdal K., Rodningen O.K. 15q11.2 microdeletion - seven new patients with delayed development and/or behavioural problems. Eur. J. Med. Genet. 2010;54:357-360.

    Not in our library10.1016/j.ejmg.2010.12.008 (opens in a new tab)

  76. 76.

    Waung M.W., Pfeiffer B.E., Nosyreva E.D., Ronesi J.A., Huber K.M. Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate. Neuron. 2008;59:84-97.

    Not in our library10.1016/j.neuron.2008.05.014 (opens in a new tab)

  77. 77.

    Wiens K.M., Lin H., Liao D. Rac1 induces the clustering of AMPA receptors during spinogenesis. J. Neurosci. 2005;25:10627-10636.

    Not in our library10.1523/jneurosci.1947-05.2005 (opens in a new tab)

  78. 78.

    Zalfa F., Giorgi M., Primerano B., Moro A., Di Penta A., Reis S., Oostra B., Bagni C. The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses. Cell. 2003;112:317-327.

    Not in our library10.1016/s0092-8674(03)00079-5 (opens in a new tab)

  79. 79.

    Zhang H., Etherington L.A., Hafner A.S., Belelli D., Coussen F., Delagrange P., Chaouloff F., Spedding M., Lambert J.J., Choquet D., Groc L. Regulation of AMPA receptor surface trafficking and synaptic plasticity by a cognitive enhancer and antidepressant molecule. Mol. Psychiatry. 2013;18:471-484.

    Not in our library10.1038/mp.2012.80 (opens in a new tab)

  80. 80.

    Zhao Q., Li T., Zhao X., Huang K., Wang T., Li Z., Ji J., Zeng Z., Zhang Z., Li K. Rare CNVs and Tag SNPs at 15q11.2 are associated with schizophrenia in the Han Chinese population. Schizophr. Bull. 2012;39:712-719.

    Not in our library10.1093/schbul/sbr197 (opens in a new tab)

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