Skip to content
naulon

No retraction, correction or concern found when last checked on Nov 1, 2026.

Neural Primacy of the Salience Processing System in Schizophrenia

Lena Palaniyappan, Molly Simmonite, Thomas P. White and 2 more

Neuron · 2013

doi:10.1016/j.neuron.2013.06.027

References 68

  1. 1.

    Barbas H. Complementary roles of prefrontal cortical regions in cognition, memory, and emotion in primates. Adv. Neurol. 2000;84:87-110.

    Not in our library

  2. 2.

    Brookes M.J., Liddle E.B., Hale J.R., Woolrich M.W., Luckhoo H., Liddle P.F., Morris P.G. Task induced modulation of neural oscillations in electrophysiological brain networks. Neuroimage. 2012;63:1918-1930.

    Not in our library10.1016/j.neuroimage.2012.08.012

  3. 3.

    Callicott J.H., Bertolino A., Mattay V.S., Langheim F.J.P., Duyn J., Coppola R., Goldberg T.E., Weinberger D.R. Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cereb. Cortex. 2000;10:1078-1092.

    Not in our library10.1093/cercor/10.11.1078

  4. 4.
  5. 5.

    Cole D.M., Oei N.Y.L., Soeter R.P., Both S., van Gerven J.M.A., Rombouts S.A.R.B., Beckmann C.F. Dopamine-dependent architecture of cortico-subcortical network connectivity. Cereb. Cortex. 2013;23:1509-1516.

    Not in our library10.1093/cercor/bhs136

  6. 6.

    Craig A.D.B. How do you feel—now? The anterior insula and human awareness. Nat. Rev. Neurosci. 2009;10:59-70.

    Not in our library10.1038/nrn2555

  7. 7.

    Dichter G.S., Bellion C., Casp M., Belger A. Impaired modulation of attention and emotion in schizophrenia. Schizophr. Bull. 2010;36:595-606.

    Not in our library10.1093/schbul/sbn118

  8. 8.

    Dickinson D., Ramsey M.E., Gold J.M. Overlooking the obvious: a meta-analytic comparison of digit symbol coding tasks and other cognitive measures in schizophrenia. Arch. Gen. Psychiatry. 2007;64:532-542.

    Not in our library10.1001/archpsyc.64.5.532

  9. 9.

    Dickinson D., Goldberg T.E., Gold J.M., Elvevåg B., Weinberger D.R. Cognitive factor structure and invariance in people with schizophrenia, their unaffected siblings, and controls. Schizophr. Bull. 2011;37:1157-1167.

    Not in our library10.1093/schbul/sbq018

  10. 10.

    Ellison-Wright I., Glahn D.C., Laird A.R., Thelen S.M., Bullmore E. The anatomy of first-episode and chronic schizophrenia: an anatomical likelihood estimation meta-analysis. Am. J. Psychiatry. 2008;165:1015-1023.

    Not in our library10.1176/appi.ajp.2008.07101562

  11. 11.

    Forget B., Pushparaj A., Le Foll B. Granular insular cortex inactivation as a novel therapeutic strategy for nicotine addiction. Biol. Psychiatry. 2010;68:265-271.

    Not in our library10.1016/j.biopsych.2010.01.029

  12. 12.

    Friston K.J. Functional and effective connectivity in neuroimaging: A synthesis. Hum. Brain Mapp. 1994;2:56-78.

    Not in our library

  13. 13.

    Garrity A.G., Pearlson G.D., McKiernan K., Lloyd D., Kiehl K.A., Calhoun V.D. Aberrant “default mode” functional connectivity in schizophrenia. Am. J. Psychiatry. 2007;164:450-457.

    Not in our library10.1176/ajp.2007.164.3.450

  14. 14.

    Glahn D.C., Laird A.R., Ellison-Wright I., Thelen S.M., Robinson J.L., Lancaster J.L., Bullmore E., Fox P.T. Meta-analysis of gray matter anomalies in schizophrenia: application of anatomic likelihood estimation and network analysis. Biol. Psychiatry. 2008;64:774-781.

    Not in our library10.1016/j.biopsych.2008.03.031

  15. 15.

    Glover G.H., Li T.Q., Ress D. Image-based method for retrospective correction of physiological motion effects in fMRI: RETROICOR. Magn. Reson. Med. 2000;44:162-167.

    Not in our library10.1002/1522-2594(200007)44:1<162::aid-mrm23>3.0.co;2-e

  16. 16.

    Goldman H.H., Skodol A.E., Lave T.R. Revising axis V for DSM-IV: a review of measures of social functioning. Am. J. Psychiatry. 1992;149:1148-1156.

    Not in our library10.1176/ajp.149.9.1148

  17. 17.

    Guller Y., Ferrarelli F., Shackman A.J., Sarasso S., Peterson M.J., Langheim F.J., Meyerand M.E., Tononi G., Postle B.R. Probing thalamic integrity in schizophrenia using concurrent transcranial magnetic stimulation and functional magnetic resonance imaging. Arch. Gen. Psychiatry. 2012;69:662-671.

    Not in our library10.1001/archgenpsychiatry.2012.23

  18. 18.

    Hamilton J.P., Chen G., Thomason M.E., Schwartz M.E., Gotlib I.H. Investigating neural primacy in Major Depressive Disorder: multivariate Granger causality analysis of resting-state fMRI time-series data. Mol. Psychiatry. 2011;16:763-772.

    Not in our library10.1038/mp.2010.46

  19. 19.

    Hasenkamp W., James G.A., Boshoven W., Duncan E. Altered engagement of attention and default networks during target detection in schizophrenia. Schizophr. Res. 2011;125:169-173.

    Not in our library10.1016/j.schres.2010.08.041

  20. 20.

    Javitt D.C. Sensory processing in schizophrenia: neither simple nor intact. Schizophr. Bull. 2009;35:1059-1064.

    Not in our library10.1093/schbul/sbp110

  21. 21.

    Johnston K., Levin H.M., Koval M.J., Everling S. Top-down control-signal dynamics in anterior cingulate and prefrontal cortex neurons following task switching. Neuron. 2007;53:453-462.

    Not in our library10.1016/j.neuron.2006.12.023

  22. 22.

    Kasparek T., Prikryl R., Rehulova J., Marecek R., Mikl M., Prikrylova H., Vanicek J., Ceskova E. Brain functional connectivity of male patients in remission after the first episode of schizophrenia. Hum. Brain Mapp. 2013;34:726-737.

    Not in our library10.1002/hbm.21469

  23. 23.
  24. 24.

    Koski L., Paus T. Functional connectivity of the anterior cingulate cortex within the human frontal lobe: a brain-mapping meta-analysis. Exp. Brain Res. 2000;133:55-65.

    Not in our library10.1007/s002210000400

  25. 25.

    Kurth F., Zilles K., Fox P.T., Laird A.R., Eickhoff S.B. A link between the systems: functional differentiation and integration within the human insula revealed by meta-analysis. Brain Struct. Funct. 2010;214:519-534.

    Not in our library10.1007/s00429-010-0255-z

  26. 26.

    Leckman J.F., Sholomskas D., Thompson W.D., Belanger A., Weissman M.M. Best estimate of lifetime psychiatric diagnosis: a methodological study. Arch. Gen. Psychiatry. 1982;39:879-883.

    Not in our library10.1001/archpsyc.1982.04290080001001

  27. 27.

    Lewis D.A., Hashimoto T., Volk D.W. Cortical inhibitory neurons and schizophrenia. Nat. Rev. Neurosci. 2005;6:312-324.

    Not in our library10.1038/nrn1648

  28. 28.

    Lewis C.M., Baldassarre A., Committeri G., Romani G.L., Corbetta M. Learning sculpts the spontaneous activity of the resting human brain. Proc. Natl. Acad. Sci. USA. 2009;106:17558-17563.

    Not in our library10.1073/pnas.0902455106

  29. 29.

    Liddle P.F., Ngan E.T.C., Duffield G., Kho K., Warren A.J. Signs and Symptoms of Psychotic Illness (SSPI): a rating scale. Br. J. Psychiatry. 2002;180:45-50.

    Not in our library10.1192/bjp.180.1.45

  30. 30.

    Mars R.B., Salle J., Rushworth M.F.S., Yeung N. Neural Basis of Motivational and Cognitive Control. 2012.

    Not in our library

  31. 31.

    Medalla M., Barbas H. Synapses with inhibitory neurons differentiate anterior cingulate from dorsolateral prefrontal pathways associated with cognitive control. Neuron. 2009;61:609-620.

    Not in our library10.1016/j.neuron.2009.01.006

  32. 32.

    Medford N., Critchley H.D. Conjoint activity of anterior insular and anterior cingulate cortex: awareness and response. Brain Struct. Funct. 2010;214:535-549.

    Not in our library10.1007/s00429-010-0265-x

  33. 33.

    Menon V., Uddin L.Q. Saliency, switching, attention and control: a network model of insula function. Brain Struct. Funct. 2010;214:655-667.

    Not in our library10.1007/s00429-010-0262-0

  34. 34.

    Meyer-Lindenberg A.S., Olsen R.K., Kohn P.D., Brown T., Egan M.F., Weinberger D.R., Berman K.F. Regionally specific disturbance of dorsolateral prefrontal-hippocampal functional connectivity in schizophrenia. Arch. Gen. Psychiatry. 2005;62:379-386.

    Not in our library10.1001/archpsyc.62.4.379

  35. 35.

    Miller E.K., Cohen J.D. An integrative theory of prefrontal cortex function. Annu. Rev. Neurosci. 2001;24:167-202.

    Not in our library10.1146/annurev.neuro.24.1.167

  36. 36.

    Minzenberg M.J., Laird A.R., Thelen S., Carter C.S., Glahn D.C. Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia. Arch. Gen. Psychiatry. 2009;66:811-822.

    Not in our library10.1001/archgenpsychiatry.2009.91

  37. 37.

    Molina V., Solera S., Sanz J., Sarramea F., Luque R., Rodríguez R., Jiménez-Arriero M.A., Palomo T. Association between cerebral metabolic and structural abnormalities and cognitive performance in schizophrenia. Psychiatry Res. 2009;173:88-93.

    Not in our library10.1016/j.pscychresns.2008.09.009

  38. 38.

    Nygård M., Eichele T., Løberg E.-M., Jørgensen H.A., Johnsen E., Kroken R.A., Berle J.Ø., Hugdahl K. Patients with schizophrenia fail to up-regulate task-positive and down-regulate task-negative brain networks: an fMRI study using an ICA analysis approach. Front Hum Neurosci. 2012;6:149.

    Not in our library10.3389/fnhum.2012.00149

  39. 39.

    Olson I.R., Plotzker A., Ezzyat Y. The Enigmatic temporal pole: a review of findings on social and emotional processing. Brain. 2007;130:1718-1731.

    Not in our library10.1093/brain/awm052

  40. 40.

    Palaniyappan L., Liddle P.F. Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction. J. Psychiatry Neurosci. 2012;37:17-27.

    Not in our library10.1503/jpn.100176

  41. 41.

    Palaniyappan L., White T.P., Liddle P.F. The concept of salience network dysfunction in schizophrenia: from neuroimaging observations to therapeutic opportunities. Curr. Top. Med. Chem. 2012;12:2324-2338.

    Not in our library10.2174/156802612805289881

  42. 42.

    Palaniyappan L., Al-Radaideh A., Mougin O., Gowland P., Liddle P.F. Combined white matter imaging suggests myelination defects in visual processing regions in schizophrenia. Neuropsychopharmacology. 2013;38:1808-1815.

    Not in our library10.1038/npp.2013.80

  43. 43.

    Posse S., Wiese S., Gembris D., Mathiak K., Kessler C., Grosse-Ruyken M.L., Elghahwagi B., Richards T., Dager S.R., Kiselev V.G. Enhancement of BOLD-contrast sensitivity by single-shot multi-echo functional MR imaging. Magn. Reson. Med. 1999;42:87-97.

    Not in our library10.1002/(sici)1522-2594(199907)42:1<87::aid-mrm13>3.0.co;2-o

  44. 44.

    Potkin S.G., Turner J.A., Brown G.G., McCarthy G., Greve D.N., Glover G.H., Manoach D.S., Belger A., Diaz M., Wible C.G., FBIRN. Working memory and DLPFC inefficiency in schizophrenia: the FBIRN study. Schizophr. Bull. 2009;35:19-31.

    Not in our library10.1093/schbul/sbn162

  45. 45.

    Preacher K.J., Hayes A.F. SPSS and SAS procedures for estimating indirect effects in simple mediation models. Behav. Res. Methods Instrum. Comput. 2004;36:717-731.

    Not in our library10.3758/bf03206553

  46. 46.

    Preacher K.J., Hayes A.F. Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behav. Res. Methods. 2008;40:879-891.

    Not in our library10.3758/brm.40.3.879

  47. 47.

    Pu W., Li L., Zhang H., Ouyang X., Liu H., Zhao J., Li L., Xue Z., Xu K., Tang H. Morphological and functional abnormalities of salience network in the early-stage of paranoid schizophrenia. Schizophr. Res. 2012;141:15-21.

    Not in our library10.1016/j.schres.2012.07.017

  48. 48.

    Reynolds G.P., Zhang Z.J., Beasley C.L. Neurochemical correlates of cortical GABAergic deficits in schizophrenia: selective losses of calcium binding protein immunoreactivity. Brain Res. Bull. 2001;55:579-584.

    Not in our library10.1016/s0361-9230(01)00526-3

  49. 49.

    Rodríguez-Sánchez J.M., Crespo-Facorro B., González-Blanch C., Perez-Iglesias R., Vázquez-Barquero J.L., PAFIP Group Study. Cognitive dysfunction in first-episode psychosis: the processing speed hypothesis. Br. J. Psychiatry Suppl. 2007;51:s107-s110.

    Not in our library10.1192/bjp.191.51.s107

  50. 50.

    Rose D., Pevalin D.J. A Researcher’s Guide to the National Statistics Socio-economic Classification. 2003.

    Not in our library

  51. 51.

    Ruiz S., Lee S., Soekadar S.R., Caria A., Veit R., Kircher T., Birbaumer N., Sitaram R. Acquired self-control of insula cortex modulates emotion recognition and brain network connectivity in schizophrenia. Hum. Brain Mapp. 2013;34:200-212.

    Not in our library10.1002/hbm.21427

  52. 52.

    Sadaghiani S., Scheeringa R., Lehongre K., Morillon B., Giraud A.-L., Kleinschmidt A. Intrinsic connectivity networks, alpha oscillations, and tonic alertness: a simultaneous electroencephalography/functional magnetic resonance imaging study. J. Neurosci. 2010;30:10243-10250.

    Not in our library10.1523/jneurosci.1004-10.2010

  53. 53.

    Schippers M.B., Renken R., Keysers C. The effect of intra- and inter-subject variability of hemodynamic responses on group level Granger causality analyses. Neuroimage. 2011;57:22-36.

    Not in our library10.1016/j.neuroimage.2011.02.008

  54. 54.

    Seeley W.W., Menon V., Schatzberg A.F., Keller J., Glover G.H., Kenna H., Reiss A.L., Greicius M.D. Dissociable intrinsic connectivity networks for salience processing and executive control. J. Neurosci. 2007;27:2349-2356.

    Not in our library10.1523/jneurosci.5587-06.2007

  55. 55.

    Seth A.K., Suzuki K., Critchley H.D. An interoceptive predictive coding model of conscious presence. Front. Psychol. 2011;2:395.

    Not in our library10.3389/fpsyg.2011.00395

  56. 56.

    Singer T., Critchley H.D., Preuschoff K. A common role of insula in feelings, empathy and uncertainty. Trends Cogn. Sci. 2009;13:334-340.

    Not in our library10.1016/j.tics.2009.05.001

  57. 57.

    Slotema C.W., Aleman A., Daskalakis Z.J., Sommer I.E. Meta-analysis of repetitive transcranial magnetic stimulation in the treatment of auditory verbal hallucinations: update and effects after one month. Schizophr. Res. 2012;142:40-45.

    Not in our library10.1016/j.schres.2012.08.025

  58. 58.

    Smith S.M., Miller K.L., Salimi-Khorshidi G., Webster M., Beckmann C.F., Nichols T.E., Ramsey J.D., Woolrich M.W. Network modelling methods for FMRI. Neuroimage. 2011;54:875-891.

    Not in our library10.1016/j.neuroimage.2010.08.063

  59. 59.

    Sridharan D., Levitin D.J., Menon V. A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks. Proc. Natl. Acad. Sci. USA. 2008;105:12569-12574.

    Not in our library10.1073/pnas.0800005105

  60. 60.

    Su L., Bowman H., Barnard P. Glancing and then looking: on the role of body, affect, and meaning in cognitive control. Front. Psychol. 2011;2:348.

    Not in our library10.3389/fpsyg.2011.00348

  61. 61.

    Tu P.-C., Hsieh J.-C., Li C.-T., Bai Y.-M., Su T.-P. Cortico-striatal disconnection within the cingulo-opercular network in schizophrenia revealed by intrinsic functional connectivity analysis: a resting fMRI study. Neuroimage. 2012;59:238-247.

    Not in our library10.1016/j.neuroimage.2011.07.086

  62. 62.

    Van Snellenberg J.X., Torres I.J., Thornton A.E. Functional neuroimaging of working memory in schizophrenia: task performance as a moderating variable. Neuropsychology. 2006;20:497-510.

    Not in our library10.1037/0894-4105.20.5.497

  63. 63.

    Vercammen A., Knegtering H., Liemburg E.J., den Boer J.A., Aleman A. Functional connectivity of the temporo-parietal region in schizophrenia: effects of rTMS treatment of auditory hallucinations. J. Psychiatr. Res. 2010;44:725-731.

    Not in our library10.1016/j.jpsychires.2009.12.011

  64. 64.

    Weinberger D.R., Berman K.F., Suddath R., Torrey E.F. Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins. Am. J. Psychiatry. 1992;149:890-897.

    Not in our library10.1176/ajp.149.7.890

  65. 65.

    White T.P., Joseph V., Francis S.T., Liddle P.F. Aberrant salience network (bilateral insula and anterior cingulate cortex) connectivity during information processing in schizophrenia. Schizophr. Res. 2010;123:105-115.

    Not in our library10.1016/j.schres.2010.07.020

  66. 66.

    Whitfield-Gabrieli S., Ford J.M. Default mode network activity and connectivity in psychopathology. Annu. Rev. Clin. Psychol. 2012;8:49-76.

    Not in our library10.1146/annurev-clinpsy-032511-143049

  67. 67.

    Zang Z.-X., Yan C.-G., Dong Z.-Y., Huang J., Zang Y.-F. Granger causality analysis implementation on MATLAB: a graphic user interface toolkit for fMRI data processing. J. Neurosci. Methods. 2012;203:418-426.

    Not in our library10.1016/j.jneumeth.2011.10.006

  68. 68.

    Zeidan F., Martucci K.T., Kraft R.A., Gordon N.S., McHaffie J.G., Coghill R.C. Brain mechanisms supporting the modulation of pain by mindfulness meditation. J. Neurosci. 2011;31:5540-5548.

    Not in our library10.1523/jneurosci.5791-10.2011

Cited by papers we hold 8

Reads

Read by people on this page

None yet.

Checked or read by AI through naulon

None yet.

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.

Are you an author?

Is this your paper?

Claim it to add your note and be paid when agents cite it. Free.