Re-evaluating the role of TPJ in attentional control: Contextual updating?

1The right temporo-parietal junction (TPJ) is widely considered to be a critical part of a right-lateralized ventral attentional control network that reorients attention toward the appearance of unexpected, but task-relevant objects. This view is almost ubiquitous within the field of attention and has been heavily drawn upon by other psychological domains (e.g., ). However, despite many demonstrations that TPJ responds to stimuli that are unexpected and task-relevant, there is little direct evidence for two specific aspects of the model: First, that TPJ activity triggers the reorientation of attention (in space, time, or by feature); and second, that TPJ function in attentional control is strictly right-lateralized.

2Understanding TPJ is important not only because attention is a core cognitive function that contributes to many other domains of information processing, but also because TPJ has been identified as a key structure in seemingly unrelated domains (e.g., memory, body representation, theory-of-mind). In all of these domains, the attentional account of TPJ has played a critical role to either explain function or fuel debate over functional specialization. In both cases, these cross-domain exchanges assume that the responses within TPJ are fundamentally dedicated to computations in either attentional reorienting or another domain. The argument follows that if the regions (or neurons) activated by both cognitive domains (or tasks) are the same, then one function must explain the other; if they are physically separate, then they can be independent modules (see Table 1 and Fig. 1 for peak coordinates of findings attributed to TPJ from different domains; see Fig. 2 for anatomical landmarks). However, a third possibility is that there is a domain-general computation in TPJ that is neither specific for attentional reorienting nor for a single other cognitive process such as ToM, but nevertheless critically underlies all of them (see also, ).

3The purpose of this review is to critically evaluate two core assumptions about the role of TPJ in attentional control in order to highlight the need to reconsider theories of TPJ function. As an alternative account, we then propose the “contextual updating” hypothesis in which the function of TPJ is to update internal models of the current behavioral context for the purpose of generating appropriate actions; contextual updating is therefore particularly important when unexpected stimuli occur. A similar idea has long existed within the event-related potentials (ERP) literature with respect to the P300 component, which is thought to have a number of neural sources including TPJ.

4While the contextual updating hypothesis implies an unitary account for TPJ function, we readily acknowledge that it is likely that there are multiple specialized sub-regions in “TPJ”. However, given the number of different cognitive and emotional processes that have been identified in the larger TPJ region and uncertainty regarding the anatomical separation of different functions (compare Figs. 1 and 2), we believe that it is currently still useful to identify common computational principles across domains rather than to fragment the region into separate cognitive modules. After all, we do not know what the dividing principles should be and they may very well violate the topical and task-based divisions we currently rely on to divide fields of study. Our approach is in line with other recent theories that provide integrative explanations for why TPJ may be found in multiple domains of study.

5The review is structured in five sections: the first reviews the evidence for the role of TPJ in attention based on human functional magnetic resonance imaging (fMRI) and neuropsychology; the second reconsiders the evidence for two commonly accepted characteristics of TPJ in attention; the third discusses the contextual updating hypothesis for TPJ with respect to studies of attention; the fourth section evaluates (necessarily in brief) the generalizability of the contextual updating hypothesis to other psychological domains; finally, in the fifth section, we discuss recent anatomical work that contributes importantly to the anatomical definitions for the region of cortex broadly referred to as TPJ.

6Perhaps the most prevalent theory of TPJ function, particularly in the right hemisphere, comes from Maurizio Corbetta and colleagues. In this theory, TPJ is part of a “ventral attentional control network” that also includes the inferior frontal gyrus and middle frontal gyrus. This ventral network is thought to be responsible for the reorientation of attention to behaviorally relevant, but currently unattended stimuli (note that the reorientation need not be spatial in nature). Stimulus-driven changes in attentional focus are frequently referred to as “bottom-up” reorientation and can be understood in contrast to “top-down” mechanisms that control voluntary attentional selection (for review see ). Early evidence for TPJ in reorienting attention came from variations of the Posner task in which spatial cues indicate the position of behaviorally relevant targets with a given probability. Greater right hemispheric TPJ activation occurred in response to invalidly cued targets. For example, found greater TPJ activation in response to invalid targets and moreover, invalid target activation was greater when the cue validity was 90% as compared to only 60% and that this corresponded with the size of the behavioral validity effects (i.e., the difference in RT between invalid and valid targets). This suggested that activation in right TPJ and the right frontal cortex was commensurate with the strength of the violation of expectations. Importantly, TPJ responses are not due to “bottom-up” sensory salience as task-irrelevant salient stimuli do not activate TPJ, but rather FEF and IPS.

7In addition to spatially “invalid” targets, TPJ is also sensitive to relevance defined by other stimulus dimensions such as: target-similarity, cues that indicate a need to shift spatial attention, as well as “surprising” stimuli that may reorient attention, albeit not in the spatial dimension. Although these stimuli are superficially dissimilar to a target in an invalidly cued spatial location, they are all external stimuli that trigger a shift in attention because they have features that are potentially relevant for a task-based decisions. Together, such results led to the idea that TPJ and the ventral attentional network are suppressed during “top-down” guided attentional processes, but are activated in order to “circuit-break” the voluntary attentional control system to reorient attention to unexpected, but relevant information.

8Support for the notion that right TPJ plays a crucial role in reorienting attention to unexpected sensory stimuli comes from spatial neglect. Spatial neglect is a neuropsychological phenomenon that is defined by behavioral symptoms of a deficit in spontaneously reorienting attention to stimulus information in the contralesional visual field. Spatial neglect cannot be attributed to either sensory or motor defects alone and is associated with damage primarily to the right inferior parietal cortex. For example, found that the region of greatest overlap for patients with neglect following middle cerebral artery (MCA) territory stroke was in the white matter just beneath the rostroventral portion of the right angular gyrus. Moreover, the lack of damage to this region was a good predictor of patients without neglect, suggesting that the inferior parietal cortex makes a critical contribution to stimulus-driven attentional orienting. Others, however, have argued that that the critical brain correlate of neglect is the right superior temporal sulcus (STS), lesion volume, or disruption within a network of multiple regions. TPJ damage, including portions of the inferior parietal lobe and STS, has recently also been linked to anosognosia in neglect when visuospatial deficits are controlled for, and perceptual awareness more generally. Going further, a recent theory hypothesizes that consciousness is a meta-process that extracts information from our own attentional states of which potentially separate parietal and temporal portions of the TPJ are critical. Taken together, the work on spatial neglect suggests that TPJ in the right-hemisphere encompasses areas that are critical for stimulus-driven attentional control and awareness.

9While the neuroimaging and neuropsychological data converge in support of the model of a right-hemispheric dominant ventral attentional control network that reorients attention by communicating with the dorsal network via frontal regions, there is also evidence that this model is unlikely to be correct in its entirety. Some of these concerns were raised originally by Corbetta and colleagues (e.g., ), while others have emerged more recently. The first issue involves the timing of activity in TPJ vs. nodes of the dorsal network such as FEF. The second involves the asymmetric characterization of contributions from left and right TPJ to attentional control processes. We review each of these in turn.

10If TPJ is to send a fast-latency “interrupt” signal to the dorsal network that reorients attention, it logically follows that TPJ must generate an earlier output signal in response to sensory inputs than the dorsal system regions. However, the evidence from electrophysiology and TMS suggests that FEF actually responds earlier, not later, to sensory information than TPJ. For example, the latency of stimulus-evoked responses in FEF range from 50 to 138 ms and when FEF TMS is applied with temporal precision using double pulse TMS time-locked to stimulus onset, it affects stimulus-driven attentional orienting 30–90 ms after stimulus onset. In addition, covert attentional capture effects appear to be even earlier than those signals associated with saccadic eye-movements. In contrast, TMS of TPJ has a later effect around 150 and 250 ms after stimulus appearance.

11The precise timing of repetitive TMS is harder to evaluate, but has been reported to impair visuospatial attention tasks when applied over the ventral posterior parietal cortex for 500 ms or longer. Additionally, human neurophysiological data on a perceptual phosphene induction task found TPJ gamma activity began 100 ms after direct electrical stimulation of occipital cortex (not stimulus onset) and lasted 200 ms with an approximate peak at 200 ms. However, the fact that temporally late TMS of TPJ impacts performance does not preclude the possibility that TPJ also sends an earlier signal. One possibility is that TPJ is involved in early and late phases of information processing. Using TMS, Chambers et al. (2004) found that a post-cue disruption of the right angular gyrus at 90–120 and 210–240 ms reduced accuracy for invalid targets in a cued attention task. Interestingly, they suggest that the early signal may reflect attentional disengagement (not reorienting). Thus, while TPJ may be involved in recurrent interactions with dorsal attentional control regions such as FEF, the anterior cingulate, and other regions of prefrontal cortex, the evidence does not suggest that there is an early signal from TPJ that causally reorients attention to a new location or feature.

12ERP data recorded from scalp EEG also provide some evidence that the signal associated with TPJ is likely to occur later than that of attentional orienting signals originating in FEF and other dorsal network regions. The ERP most associated with TPJ is the P3b subcomponent of the P300. The P300 is subdivided into the P3a, which has a frontal distribution and occurs in response to novelty and the P3b, which has a more posterior scalp distribution and occurs in response to targets. Although both the P3a and P3b likely have multiple neural sources, TPJ (particularly in the supramarginal gyrus) appears to be the most prominent source for the P3b, which usually occurs 300–500 ms after stimulus onset.

13The P300 literature suggests that its neural generators encode the post-perceptual stimulus category as defined by the current task, and that this occurs relatively late after stimulus onset. This is in contrast to the earlier timing of ERP components such as the N2pc and Pd that signal the shift of attention and the suppression of target-similar distracters, respectively. One long-standing theory is that the P300 reflects “contextual updating”, which involves the modification of one's internal model of the environment (e.g., task-based expectancies) based on an external stimulus. A related hypothesis is that the context updating refers specifically to information in working memory schemas. We further explore the relationship between contextual updating and existing findings in TPJ in Section 4.

14In sum, the electrophysiological, TMS and ERP data are not consistent with the idea that TPJ sends an early reorientation signal to FEF that then shifts attention to task-relevant information (e.g., ). Although it may be that TPJ plays an important role in attentional control and interacts recurrently with dorsal regions such as FEF, the data suggest that the role of TPJ is not specifically for early stimulus-driven attentional reorienting, but involves integrating internal representations of the task context with stimulus and response expectations.

15As noted above, neuropsychological work on attention found that the behavioral deficits in spatial attention were asymmetrical (e.g., in spatial neglect) following selective damage to each hemisphere. Those findings led to a number of different theories for why such asymmetries occurred. One prominent model hypothesizes that the right hemisphere controls shifts of attention to both sides of space, but that the left hemisphere only controls shifts to the right (Mesulam, 1981). Another, the opponent-processes model, postulates that each hemisphere controls contralateral shifts by inhibiting the other hemisphere, but that the orienting signal is stronger in the left hemisphere. Thus, damage to the right releases the strong orienting response in the left hemisphere to the right side of space, but damage to the left has only a modest effect on right hemisphere orienting to the left side of space (, although see ).

16A more recent model for neglect by suggests that the spatial asymmetries are due to impaired interactions between the ventral and dorsal attentional networks; they postulate that the non-spatial functions of the ventral attentional network, in particular TPJ, cause the interactions between the left and right hemisphere nodes of the dorsal network to become imbalanced. This model is closely linked to the idea that the ventral attentional network is right-lateralized, but that the dorsal network is bilateral. Consistent with this model, differences between the right and left superior longitudinal fasiculus III connecting BA40 to prefrontal regions of the dorsal attentional network have been identified and related to measurements of attentional selection.

17There appear to be clear hemispheric differences in attentional control, but there is also increasing evidence that the left TPJ plays an important role in control processes related to attention. For example, many studies in which right TPJ is found in response to task-relevant stimuli also report left lateralized activation in similar conditions, although the left hemisphere activation is rarely investigated in detail. A notable exception is a paper by in which both left and right TPJ activation were examined in a spatial cueing paradigm. Although the contrast between invalid minus valid targets produced the commonly reported right TPJ activation, they found upon closer inspection that left TPJ responded to both invalid and valid targets. This led them to hypothesize that left TPJ encodes targets that both match and that mismatch expectations whereas right TPJ only encodes mismatches. Such a pattern would lead to the cancelation of left TPJ in statistical maps based on the contrast of invalid minus valid targets. This hypothesis is consistent with bilateral activations in “oddball” target detection tasks.

18The left TPJ is also frequently activated in studies of memory. This has led to an influential theory of episodic memory retrieval in which the posterior parietal cortex and TPJ specifically, encodes attentional capture by contents of memory that are task-relevant and match the current retrieval cue. The left-lateralization may be due to hemispheric specializations between memory vs. perceptual processes, or the fact that memory studies frequently use verbal stimuli whereas standard visual attention tasks use only perceptual stimuli. Studies of patients with parietal damage suggest that the left posterior parietal cortex may be involved in the automatic awareness of retrieved information, which is maybe more analogous to the idea that the left TPJ encodes “matches” between internal templates and external stimuli. Furthermore, connectivity analyses using RTPJ as a seed region often results in activation of the homologous left hemisphere region suggesting that TPJ in the two hemispheres are highly interconnected. Thus, while it may be that left and right TPJ have specialized functional roles, future research is required to delineate the functional relationship between the two hemispheres.

19In the previous section we reviewed evidence against the idea that TPJ provides an early stimulus-driven signal that triggers attentional reorienting. However, the existing data also clearly indicate that TPJ is engaged in processing task-relevant stimuli, particularly when they are unexpected. Here we suggest that the observed effects in TPJ can be understood in terms of “contextual updating” (see above). Although there is an unresolved debate within the ERP literature regarding the exact context representations reflected by the P3a and P3b, we believe the contextual updating hypothesis provides a fitting framework for TPJ function. We therefore suggest that a candidate computation for TPJ might be one that updates an internal model of the current environmental context based on new sensory information; we hypothesize that the update initiates a task-appropriate (covert or overt) action and a change in expectations about upcoming events.

20The contextual updating hypothesis is consistent with extant findings of TPJ activation in standard attentional tasks. For example, invalid targets in the Posner paradigm are infrequent and violate expectations and therefore produce an update to stimulus-response mappings of what action to take and what to expect in the future. Similarly, a valid target would also be predicted to activate TPJ, albeit to a lesser degree, because it signals the need to make a context-appropriate response based on the new occurrence of a target stimulus, but there is no violation of expectations.

21The contextual updating hypothesis provides similar explanations for why target-colored distracters produce TPJ activation. The appearance of a target-colored object in the wrong location violates expectations of what is to happen and requires an update to the appropriate response: the target-present response must be withheld and possibly a “non-target” response be made (depending on the task). Also similar to the spatial cueing results, targets in feature-based attention tasks would also be expected to produce significant activations in TPJ as they indicate the need to make a context-appropriate response, albeit an expected one. Mismatches to expectations produce the largest responses because they represent the most significant updates to the internal model, but matches may also be taken as evidence for the existing mental model (for similar ideas see also, ). Likewise, the appearance of a cue, or any stimulus, that requires a change in attention to anticipate task-relevant information will be followed by a model update of where relevant stimuli are likely to appear and what responses are required. Many studies that do not clearly require a reorientation of attention, but nevertheless do produce TPJ activation contain stimuli that produce such a contextual update to immediate actions or future expectations.

22The contextual updating hypothesis also fits in well with the overall goal of organisms to establish predictive expectancies that facilitate behavioral actions. We do not suggest that TPJ is itself a module for predictive coding, but rather that TPJ is a hub within larger hierarchical networks that determine the context appropriate representation of sensory input (e.g., to update actions or expectations). In this sense, the specific function of TPJ is defined within the context of a network of regions. For example, TPJ is sometimes co-activated with the default mode network (DMN), but sometimes also with task-related networks serving perceptual, somatosensory, auditory processing and motor outputs using different effectors. For example, the appearance of a stimulus that predicted the onset of a target that required a right-handed response, produced increased functional connectivity between right TPJ and bilateral dorsal attentional control regions such as FEF and IPS and left motor cortex. In another task, a right TPJ region showed increased connectivity with somatosensory cortex contralateral to a touched hand and visual cortex when subjects experienced incongruent multisensory events (Silani et al., in press).

23The flexible integration between sensory, motor, and decisional regions can also be illustrated between domains. Fig. 3 provides a schematic illustration of how activations typically observed in attention and theory of mind may contribute to function-specific networks. The illustration depicts the attentional and ToM hubs as being overlapping anatomical neighbors, but the question of whether these functional modules are anatomically overlapping or distinct is still debated (e.g., see Fig. 1). More importantly, Fig. 3 depicts the hypothesis that there is context-specific coupling between TPJ (or subregions within TPJ) and other domain-specific brain regions that create task-specific networks. While TPJ may be composed of functionally distinct subparts, we would suggest that these regions are engaged in similar computations to update internal models in different behavioral and cognitive contexts. The possibility that the exact function of TPJ is itself defined by the context of the current task is intriguing and suggests that the context (which may be updated) involves the specific pattern of coupling between regions during a task.

24Although there are still many details that need to be specified with regard to the contextual updating hypothesis, the framework is a significant deviation from the current theories and therefore stands as a reasonable alternative hypothesis: instead of initiating “bottom-up” attentional reorienting, we hypothesize that TPJ has a more general post-perceptual function in evaluating and integrating stimulus information with internal models of task performance and expectations. We note that the contextual updating hypothesis does not leave attentional reorienting without a mechanism. It is reasonable that unattended, but relevant stimuli be assigned attentional priority through “dorsal attentional” network regions in a manner similar to other salient or relevant stimuli. More studies, perhaps using tasks in which the context changes over time, are needed to assess the two main predictions: that task-defined responses and violations of expectations will produce the largest responses in TPJ.

25Any theory of TPJ function must go beyond any one sub-discipline in order to account for its involvement in different cognitive processes. The contextual updating hypothesis is appealing because similar ideas have been suggested in many domains. For example, it has been proposed that right TPJ encodes an internal model of the body and engages in a “test-for-fit” process to determine whether sensory events belong to one's own body. This hypothesis was supported by the finding that TMS over right TPJ interfered with the integration of multisensory information into the representation of one's own body. Similarly, out-of-body experiences based on the incorporation of visual and tactile information have been associated with bilateral TPJ using fMRI and voxel-based lesion symptom mapping analyses. Although these data are in relation to a very different phenomena than attentional capture, they are similar in that they both involve the updating of an internal mental model (e.g., of one's own body, where to attend, or what action to take) by sensory events relevant to the current task.

26Similarly, the contextual updating hypothesis helps to reconcile the debate between TPJ as a cognitive module for theory-of-mind (ToM) and attention tasks by suggesting a common computation occurs in both situations. The contextual updating hypothesis specifically refers to the TPJ activation and does not suggest that attentional reorienting itself does not occur during ToM (i.e., attentional reorienting may be involved in ToM tasks). While there may be anatomically separate functional modules in the posterior parietal cortex that map onto existing cognitive domains, we argue that there is utility in considering contextual updating as a common computation in a variety of tasks that selectively activate TPJ. For example, in the Sally-Anne task, the key to ToM is the ability to infer what is in the mind of Sally, whose marble has been moved by Anne while she was out of the room. In order to correctly indicate that Sally will search for the marble where she left it (and not where the observer knows it to be), the observer must update his/her internal model of where the marble currently is to reflect the context when Sally left the room. Thus, the activation of TPJ during ToM may reflect an update in contextual representation that is necessary to take another person's perspective, but may not be the perspective taking, per se. Similar computations are involved in other ToM tasks that require subjects to encode stories, picture sequences, and games that require the ability to attribute thoughts, beliefs, and other mental states to another person. Such a perspective avoids the incompatibility of interpreting TPJ activations as strictly attentional reorienting or for theory-of-mind.

27Although a comprehensive review of other cognitive domains is beyond the scope of this current review, we note that the idea of contextual updating would be compatible with a number of other studies showing TPJ involvement in altruism and empathy, perspective taking and imitation, processing lies and evaluating the emotional states of oneself relative to another (Silani et al., in press). In all these studies, an internal schema or model of environmental stimuli or another person's behaviors or thoughts must be updated relative to one's own beliefs, thoughts or actions within the same context. Interestingly, when there is no need to update potentially conflicting representations of another person's beliefs relative one's own beliefs or behavior, right TPJ is no longer involved in attributing mental states to others.

28The broader characterization of TPJ in contextual updating is consistent with its role in attentional and social-cognitive domains. Although these situations are superficially very different, they all involve a stimulus-triggered event update of internal mental models of the external environment (or person), which are then used to predict future outcomes (i.e., one's own behaviors, another person's behaviors or beliefs, or stimulus occurrences). A challenge for future studies of TPJ will be to provide insight into how the general function of contextual updating is made specific for a highly variable range of tasks and cognitive domains (e.g., through learning).

29A critical aspect of the discussion about TPJ relates to its anatomical location. Thus far, we have used the term TPJ loosely to refer to a cluster of regions in the inferior parietal lobule extending into the superior temporal gyrus (see Figs. 1 and 2). One possible reason for the variability in location is that TPJ is typically defined in fMRI through functional localization in an individual or an experiment-wide group analysis. The identification of functional regions in this manner is common practice in much of the human neuroimaging literature and is used routinely to define perceptual areas with boundaries that vary from individual-to-individual. However, localization of TPJ in humans is complicated by a lack of standard anatomical or functional definitions. Additionally, there is controversy over the existence of a non-human primate homologoue, which precludes use of monkey models to constrain the human work.

30Nevertheless, there are general conventions and TPJ is typically described as being near “the posterior sector of the superior temporal sulcus (STS) and gyrus (STG) and the ventral part of the supramarginal gyrus (SMG)” p. 307 (cf. Fig. 1). More precise definitions have been offered, but have not been systematically applied in the literature. The consequence of this non-uniformity is that the coordinates of TPJ can vary considerably between studies within the region of the inferior parietal lobe, including the inferior supramarginal gyrus, angular gyrus, and/or posterior portions of the superior temporal sulcus and gyrus. Although these differences can be seemingly small from study-to-study, they have played a critical role in the debate regarding functional specialization. In this review, we did not select studies based on the reported anatomical location, but rather included as many as we could that self-identified as TPJ (see Fig. 1).

31One exciting recent development has been creation of a new cytoarchitectonic maps based on postmortem human brains. Whereas Brodmann's areas 40 and 39 corresponded to the supramarginal and angular gyrus, respectively, Caspers and colleagues have now subdivided the inferior parietal lobe into seven areas (see Fig. 2B). These include five in BA 40 and two in BA 39. Moreover, the individual brains from the cytoarchitectonic parcellation of the inferior parietal lobe have been normalized into stereotaxic space to generate maximum probability maps for each cortical subdivision. It is now possible to assess the likelihood of any functional or structural result being in each cortical subarea using these maps, which will significantly facilitate more precise descriptions of TPJ anatomy despite interindividual variability in microanatomy and a lack of macroanatomical markers. Several studies have already begun to use these maps to establish differences in connectivity and precise functional localization using diffusion tensor imaging (DTI) and resting state functional connectivity (rs-fcMRI) analyses. These studies have shown specialization in connectivity for the newly defined subareas, much of which is consistent with previous findings that regions of the posterior parietal cortex have highly diverse connections with medial temporal lobe regions, frontal and temporal cortex.

32Interestingly, studies that have used the cytoarchtectonic parcelation scheme to identify fMRI activations in TPJ, have been more mixed. For example, in a cued attention task, invalid targets activated both PGa and PFm, regions in the anterior portion of the angular gyrus and posterior supramarginal gyrus. This is consistent overall with the characterization of TPJ as being at the intersection of the two gyri bordering the superior temporal sulcus, but also suggests that the mapping between anatomical divisions and functional localization is imperfect. This can be due to the insufficient spatial resolution of fMRI, imprecision in tasks relative to the computation of that region, interindividual variability and the application of spatial normalization techniques, or to the fact that higher-order cognitive activity may not subdivide cleanly along anatomical borders. This work suggests that understanding the role of each subdivision in cognition may require convergent methodologies that can isolate the differences in anatomy, local functional representations, stable anatomical connections, as well as potentially more flexible functional network connectivity. Nevertheless, the new anatomical divisions between regions of the inferior parietal cortex and potentially the temporal lobe, will aid finer classification of imaging results and targets for brain stimulation.

33Regions of the inferior parietal lobe within the supramarginal and angular gyri have commonly been referred to collectively as the temporoparietal junction. In the extant literature on attention, the exact location of TPJ has varied between studies considerably since the definition is frequently based on functional contrasts across a group rather than individual functional or anatomical locations. It is possible that different studies are actually referring to different subregions that are near anatomical neighbors. Although it may well be the case that the results we reviewed will someday be discovered to be anatomically distinct, the review was aimed at addressing the question of what common computation the results attributed to TPJ might perform; even if the specific nature of representations between subregions are separable, neighbors are likely to be computationally similar.

34Here we have proposed that a likely framework for TPJ function can be found in the idea of contextual updating: that the purpose of TPJ is to update internal models of the environment (including other people) for the purpose of constructing appropriate expectations and responses. These may occur for attention to simple stimuli as well as for understanding social cognition and our bodies. The anatomical connectivity between TPJ and the medial temporal lobe and frontal regions situates it well to integrate internal (or memory) representations of the current context with context-appropriate sensory-to-motor transformations. Such a framework describes well the myriad deficits that are involved with brain damage to this region and the many different tasks that produce activation in this region, but there is still much to be done to characterize the functional profile of TPJ as well its anatomical demarcations. Nevertheless, we hypothesize that the context of current events and behavioral goals will be critical to the function of this region. Much is still to be discovered about the function of TPJ, but the evidence indicates that we need to reevaluate the idea that it is involved in sending a fast-latency interrupt signal to dorsal attentional control regions and that its function is right-lateralized.