A case of relapsed anti-glomerular basement membrane glomerulonephritis complicated by IgG4-related disease

A case of relapsed anti-glomerular basement membrane glomerulonephritis complicated by IgG4-related diseaseUn caso de glomerulonefritis recidivante de la membrana basal antiglomerular complicada por una enfermedad relacionada con la IgG4Dear Editor, Anti-glomerular basement membrane (GBM) glomerulonephritis is an autoimmune disease triggered by autoantibodies against the NC1 domain of the ␣3 chain of type IV collagen (␣3(IV)NC1).Anti-GBM glomerulonephritis rarely relapse after remission.1,2 Rare cases of anti-GBM glomerulonephritis complicated by IgG4-related disease (IgG4-RD) have been reported.3 Here, we report a rare case of anti-GBM glomerulonephritis complicated by type 1 autoimmune pancreatitis (AIP), a pancreatic manifestation of IgG4-RD, in a patient who experienced a relapse after remission.

Abstract licence: CC BY-NC-ND

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   Patients double-seropositive for ANCA and anti-GBM antibodies have varied renal survival, frequency of relapse, and outcomes compared to single-seropositive patients · 2017

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