The Nucleolus under Stress

Abstract

Cells typically respond quickly to stress, altering their metabolism to compensate. In mammalian cells, stress signaling usually leads to either cell-cycle arrest or apoptosis, depending on the severity of the insult and the ability of the cell to recover. Stress also often leads to reorganization of nuclear architecture, reflecting the simultaneous inhibition of major nuclear pathways (e.g., replication and transcription) and activation of specific stress responses (e.g., DNA repair). In this review, we focus on how two nuclear organelles, the nucleolus and the Cajal body, respond to stress. The nucleolus senses stress and is a central hub for coordinating the stress response. We review nucleolar function in the stress-induced regulation of p53 and the specific changes in nucleolar morphology and composition that occur upon stress. Crosstalk between nucleoli and CBs is also discussed in the context of stress responses.

Cited by papers we hold 18

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• Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload · 2019
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• Phase-to-Phase With Nucleoli – Stress Responses, Protein Aggregation and Novel Roles of RNA · 2019
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• Evidence for and against Liquid-Liquid Phase Separation in the Nucleus · 2019
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• Compositional adaptability in NPM1-SURF6 scaffolding networks enabled by dynamic switching of phase separation mechanisms · 2018
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• Nucleolar Stress: hallmarks, sensing mechanism and diseases · 2018
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• TGFβ/Activin signalling is required for ribosome biogenesis and cell growth in Drosophila salivary glands · 2017
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• Ribosomal Proteins Control or Bypass p53 during Nucleolar Stress · 2017
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• Small nucleoli are a cellular hallmark of longevity · 2017
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• Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans · 2016
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• A redox mechanism underlying nucleolar stress sensing by nucleophosmin · 2016
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• Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress · 2016
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• Ribosomopathies: how a common root can cause a tree of pathologies · 2015
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• Identification and Characterization of a Novel Non-Structural Protein of Bluetongue Virus · 2011
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