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Cell biology of Candida albicans–host interactions

Alessandra da Silva Dantas, Kathy K Lee, Ingrida Raziunaite and 4 more

Current Opinion in Microbiology · 2016 · Review · CC BY

doi:10.1016/j.mib.2016.08.006

Abstract

Candida albicans is a commensal coloniser of most people and a pathogen of the immunocompromised or patients in which barriers that prevent dissemination have been disrupted. Both the commensal and pathogenic states involve regulation and adaptation to the host microenvironment. The pathogenic potential can be downregulated to sustain commensalism or upregulated to damage host tissue and avoid and subvert immune surveillance. In either case it seems as though the cell biology of this fungus has evolved to enable the establishment of different types of relationships with the human host. Here we summarise latest advances in the analysis of mechanisms that enable C. albicans to occupy different body sites whilst avoiding being eliminated by the sentinel activities of the human immune system.

References 68

1.
Kullberg B.J., Arendrup M.C. Invasive Candidiasis. N Engl J Med. 2015;373:1445-1456.
Not in our library10.1056/nejmra1315399
2.
Brown G.D., Denning D.W., Gow N.A.R., Levitz S.M., Netea M.G., White T.C. Hidden killers: human fungal infections. Sci Transl Med. 2012;4:165rv13.
Not in our library10.1126/scitranslmed.3004404
3.
Erwig L.P., Gow N.A.R. Interactions of fungal pathogens with phagocytes. Nat Rev Microbiol. 2016;14:163-176.
Not in our library10.1038/nrmicro.2015.21
4.
Sudbery P.E. Growth of Candida albicans hyphae. Nat Rev Immunol. 2011;9:737-748.
Not in our library10.1038/nrmicro2636
5.
The role of phenotypic switching in the basic biology and pathogenesis of Candida albicans · 2014
Not checked
6.
Netea M.G., Joosten L.A.B., van der Meer J.W.M., Kullberg B.-J., van de Veerdonk F.L. Immune defence against Candida fungal infections. Nat Rev Immunol. 2015;15:630-642.
Not in our library10.1038/nri3897
7.
Vautier S., Drummond R.A., Chen K., Murray G.I., Kadosh D., Brown A.J.P., Gow N.A.R., MacCallum D.M., Kolls J.K., Brown G.D. Candida albicans colonization and dissemination from the murine gastrointestinal tract: the influence of morphology and Th17 immunity. Cell Microbiol. 2015;17:445-450.
Not in our library10.1111/cmi.12388
8.
Pande K., Chen C., Noble S.M. Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism. Nat Genet. 2013;45:1088-1091.
Not in our library10.1038/ng.2710
9.
Neville B.A., d’Enfert C., Bougnoux M.-E. Candida albicans commensalism in the gastrointestinal tract. FEMS Yeast Res. 2015;15.
Not in our library10.1093/femsyr/fov081
10.
Yamaguchi N., Sonoyama K., Kikuchi H., Nagura T., Aritsuka T., Kawabata J. Gastric colonization of Candida albicans differs in mice fed commercial and purified diets. J Nutr. 2005;135:109-115.
Not in our library10.1093/jn/135.1.109
11.
Sokol H., Leducq V., Aschard H., Pham H.-P., Jegou S., Landman C., Cohen D., Liguori G., Bourrier A., Nion-Larmurier I. Fungal microbiota dysbiosis in IBD. Gut. 2016.
Not in our library10.1136/gutjnl-2015-310746
12.
Li Q., Wang C., Tang C., He Q., Li N., Li J. Dysbiosis of gut fungal microbiota is associated with mucosal inflammation in Crohn's disease. J Clin Gastroenterol. 2014;48:513-523.
Not in our library10.1097/mcg.0000000000000035
13.
Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation · 2014
No notice
14.
Iliev I.D., Funari V.A., Taylor K.D., Nguyen Q., Reyes C.N., Strom S.P., Brown J., Becker C.A., Fleshner P.R., Dubinsky M. Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis. Science. 2012;336:1314-1317.
Not in our library10.1126/science.1221789
15.
Underhill D.M., Iliev I.D. The mycobiota: interactions between commensal fungi and the host immune system. Nat Rev Immunol. 2014;14:405-416.
Not in our library10.1038/nri3684
16.
Zelante T., Iannitti R.G., Cunha C., De Luca A., Giovannini G., Pieraccini G., Zecchi R., D’Angelo C., Massi-Benedetti C., Fallarino F. Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. Immunity. 2013;39:372-385.
Not in our library10.1016/j.immuni.2013.08.003
17.
Kumar S., Bansal A., Chakrabarti A., Singhi S. Evaluation of efficacy of probiotics in prevention of candida colonization in a PICU — a randomized controlled trial. Crit Care Med. 2013;41:565-572.
Not in our library10.1097/ccm.0b013e31826a409c
18.
Brown A.J.P., Budge S., Kaloriti D., Tillmann A., Jacobsen M.D., Yin Z., Ene I.V., Bohovych I., Sandai D., Kastora S. Stress adaptation in a pathogenic fungus. J Exp Biol. 2014;217:144-155.
Not in our library10.1242/jeb.088930
19.
Hall R.A. Dressed to impress: impact of environmental adaptation on the Candida albicans cell wall. Mol Microbiol. 2015;97:7-17.
Not in our library10.1111/mmi.13020
20.
Metabolism impacts upon Candida immunogenicity and pathogenicity at multiple levels · 2014
No notice
21.
Childers D.S., Raziunaite I., Mol Avelar G., Mackie J., Budge S., Stead D., Gow N.A.R., Lenardon M.D., Ballou E.R., MacCallum D.M. The rewiring of ubiquitination targets in a pathogenic yeast promotes metabolic flexibility, host colonization and virulence. PLoS Pathog. 2016;12:e1005566.
Not in our library10.1371/journal.ppat.1005566
22.
The Evolutionary Rewiring of Ubiquitination Targets Has Reprogrammed the Regulation of Carbon Assimilation in the Pathogenic Yeast <named-content content-type="genus-species">Candida albicans</named-content> · 2012
Not checked
23.
Carbon source‐induced reprogramming of the cell wall proteome and secretome modulates the adherence and drug resistance of the fungal pathogen C andida albicans · 2012
No notice
24.
Lan C.-Y., Newport G., Murillo L.A., Jones T., Scherer S., Davis R.W., Agabian N. Metabolic specialization associated with phenotypic switching in Candida albicans. Proc Natl Acad Sci U S A. 2002;99:14907-14912.
Not in our library10.1073/pnas.232566499
25.
Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen · 2012
No notice
26.
Stage Specific Assessment of Candida albicans Phagocytosis by Macrophages Identifies Cell Wall Composition and Morphogenesis as Key Determinants · 2012
No notice
27.
Mannosylation in C andida albicans : role in cell wall function and immune recognition · 2013
No notice
28.
Crawford A., Wilson D. Essential metals at the host–pathogen interface: nutritional immunity and micronutrient assimilation by human fungal pathogens. FEMS Yeast Res. 2015;15.
Not in our library10.1093/femsyr/fov071
29.
Li C.X., Gleason J.E., Zhang S.X., Bruno V.M., Cormack B.P., Culotta V.C. Candida albicans adapts to host copper during infection by swapping metal cofactors for superoxide dismutase. Proc Natl Acad Sci U S A. 2015;112:E5336-E5342.
Not in our library10.1073/pnas.1513447112
30.
Schaller M., Borelli C., Korting H.C., Hube B. Hydrolytic enzymes as virulence factors of Candida albicans. Mycoses. 2005;48:365-377.
Not in our library10.1111/j.1439-0507.2005.01165.x
31.
Gropp K., Schild L., Schindler S., Hube B., Zipfel P.F., Skerka C. The yeast Candida albicans evades human complement attack by secretion of aspartic proteases. Mol Immunol. 2009;47:465-475.
Not in our library10.1016/j.molimm.2009.08.019
32.
Hube B., Monod M., Schofield D.A., Brown A.J., Gow N.A. Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans. Mol Microbiol. 1994;14:87-99.
Not in our library10.1111/j.1365-2958.1994.tb01269.x
33.
Svoboda E., Schneider A.E., Sándor N., Lermann U., Staib P., Kremlitzka M., Bajtay Z., Barz D., Erdei A., Józsi M. Secreted aspartic protease 2 of Candida albicans inactivates factor H and the macrophage factor H-receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18). Immunol Lett. 2015;168:13-21.
Not in our library10.1016/j.imlet.2015.08.009
34.
Secretory Aspartyl Proteinases Cause Vaginitis and Can Mediate Vaginitis Caused by <named-content content-type="genus-species">Candida albicans</named-content> in Mice · 2015
Not checked
35.
Pietrella D., Pandey N., Gabrielli E., Pericolini E., Perito S., Kasper L., Bistoni F., Cassone A., Hube B., Vecchiarelli A. Secreted aspartic proteases of Candida albicans activate the NLRP3 inflammasome. Eur J Immunol. 2013;43:679-692.
Not in our library10.1002/eji.201242691
36.
Gabrielli E., Pericolini E., Luciano E., Sabbatini S., Roselletti E., Perito S., Kasper L., Hube B., Vecchiarelli A. Induction of caspase-11 by aspartyl proteinases of Candida albicans and implication in promoting inflammatory response. Infect Immun. 2015;83:1940-1948.
Not in our library10.1128/iai.02895-14
37.
Wu H., Downs D., Ghosh K., Ghosh A.K., Staib P., Monod M., Tang J. Candida albicans secreted aspartic proteases 4-6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism. FASEB J Off Publ Fed Am Soc Exp Biol. 2013;27:2132-2144.
Not in our library10.1096/fj.12-214353
38.
Moyes D.L., Wilson D., Richardson J.P., Mogavero S., Tang S.X., Wernecke J., Höfs S., Gratacap R.L., Robbins J., Runglall M. Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature. 2016;532:64-68.
Not in our library10.1038/nature17625
39.
Naglik J.R., Moyes D.L., Wächtler B., Hube B. Candida albicans interactions with epithelial cells and mucosal immunity. Microbes Infect Inst Pasteur. 2011;13:963-976.
Not in our library10.1016/j.micinf.2011.06.009
40.
Yang W., Yan L., Wu C., Zhao X., Tang J. Fungal invasion of epithelial cells. Microbiol Res. 2014;169:803-810.
Not in our library10.1016/j.micres.2014.02.013
41.
A Biphasic Innate Immune MAPK Response Discriminates between the Yeast and Hyphal Forms of Candida albicans in Epithelial Cells · 2010
No notice
42.
Nobile C.J., Johnson A.J. Candida albicans biofilms and human disease. Annu Rev Microbiol. 2015;69:71-92.
Not in our library10.1146/annurev-micro-091014-104330
43.
Jacobsen I.D., Wilson D., Wächtler B., Brunke S., Naglik J.R., Hube B. Candida albicans dimorphism as a therapeutic target. Expert Rev Anti Infect Ther. 2012;10:85-93.
Not in our library10.1586/eri.11.152
44.
Goyer M., Loiselet A., Bon F., L’Ollivier C., Laue M., Holland G., Bonnin A., Dalle F. Intestinal cell tight junctions limit invasion of Candida albicans through active penetration and endocytosis in the early stages of the interaction of the fungus with the intestinal barrier. PloS One. 2016;11:e0149159.
Not in our library10.1371/journal.pone.0149159
45.
Candida glabrata Binding to Candida albicans Hyphae Enables Its Development in Oropharyngeal Candidiasis · 2016
No notice
46.
Candida albicans cell surface superoxide dismutases degrade host‐derived reactive oxygen species to escape innate immune surveillance · 2008
No notice
47.
Oxidative Stress Responses in the Human Fungal Pathogen, Candida albicans · 2015
No notice
48.
Quintin J., Saeed S., Martens J.H.A., Giamarellos-Bourboulis E.J., Ifrim D.C., Logie C., Jacobs L., Jansen T., Kullberg B.-J., Wijmenga C. Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes. Cell Host Microbe. 2012;12:223-232.
Not in our library10.1016/j.chom.2012.06.006
49.
Saeed S., Quintin J., Kerstens H.H.D., Rao N.A., Aghajanirefah A., Matarese F., Cheng S.-C., Ratter J., Berentsen K., van der Ent M.A. Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity. Science. 2014;345:1251086.
Not in our library10.1126/science.1251086
50.
Gow N.A.R., van de Veerdonk F.L., Brown A.J.P., Netea M.G. Candida albicans morphogenesis and host defence: discriminating invasion from colonization. Nat Rev Microbiol. 2012;10:112-122.
Not in our library10.1038/nrmicro2711
51.
Joly S., Ma N., Sadler J.J., Soll D.R., Cassel S.L., Sutterwala F.S. Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome. J Immunol Baltim Md 1950. 2009;183:3578-3581.
Not in our library10.4049/jimmunol.0901323
52.
Geiger J., Wessels D., Lockhart S.R., Soll D.R. Release of a potent polymorphonuclear leukocyte chemoattractant is regulated by white-opaque switching in Candida albicans. Infect Immun. 2004;72:667-677.
Not in our library10.1128/iai.72.2.667-677.2004
53.
Lohse M.B., Johnson A.D. Differential phagocytosis of white versus opaque Candida albicans by Drosophila and mouse phagocytes. PloS One. 2008;3:e1473.
Not in our library10.1371/journal.pone.0001473
54.
Miramón P., Kasper L., Hube B. Thriving within the host: Candida spp. interactions with phagocytic cells. Med Microbiol Immunol (Berl). 2013;202:183-195.
Not in our library10.1007/s00430-013-0288-z
55.
Modulation of Phagosomal pH by Candida albicans Promotes Hyphal Morphogenesis and Requires Stp2p, a Regulator of Amino Acid Transport · 2014
No notice
56.
Danhof H.A., Lorenz M.C. The Candida albicans ATO gene family promotes neutralization of the macrophage phagolysosome. Infect Immun. 2015;83:4416-4426.
Not in our library10.1128/iai.00984-15
57.
Munro C.A., Selvaggini S., de Bruijn I., Walker L., Lenardon M.D., Gerssen B., Milne S., Brown A.J.P., Gow N.A.R. The PKC, HOG and Ca2+ signalling pathways co-ordinately regulate chitin synthesis in Candida albicans. Mol Microbiol. 2007;63:1399-1413.
Not in our library10.1111/j.1365-2958.2007.05588.x
58.
Participation of Candida albicans transcription factor RLM1 in cell wall biogenesis and virulence. · 2014
Not checked
59.
Miramón P., Dunker C., Windecker H., Bohovych I.M., Brown A.J.P., Kurzai O., Hube B. Cellular responses of Candida albicans to phagocytosis and the extracellular activities of neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress. PloS One. 2012;7:e52850.
Not in our library10.1371/journal.pone.0052850
60.
Kaloriti D., Jacobsen M., Yin Z., Patterson M., Tillmann A., Smith D.A., Cook E., You T., Grimm M.J., Bohovych I. Mechanisms underlying the exquisite sensitivity of Candida albicans to combinatorial cationic and oxidative stress that enhances the potent fungicidal activity of phagocytes. mBio. 2014;5.
Not in our library10.1128/mbio.01334-14
61.
Kos I., Patterson M.J., Znaidi S., Kaloriti D., da Silva Dantas A., Herrero-de-Dios C.M., d’Enfert C., Brown A.J.P., Quinn J. Mechanisms underlying the delayed activation of the Cap1 transcription factor in Candida albicans following combinatorial oxidative and cationic stress important for phagocytic potency. mBio. 2016;7.
Not in our library10.1128/mbio.00331-16
62.
Bain J.M., Lewis L.E., Okai B., Quinn J., Gow N.A.R., Erwig L.-P. Non-lytic expulsion/exocytosis of Candida albicans from macrophages. Fungal Genet Biol. 2012;49:677-678.
Not in our library10.1016/j.fgb.2012.01.008
63.
Joly S., Eisenbarth S.C., Olivier A.K., Williams A., Kaplan D.H., Cassel S.L., Flavell R.A., Sutterwala F.S. Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans. J Immunol Baltim Md 1950. 2012;189:4713-4717.
Not in our library10.4049/jimmunol.1201715
64.
Krysan D.J., Sutterwala F.S., Wellington M. Catching fire: Candida albicans, macrophages, and pyroptosis. PLoS Pathog. 2014;10:e1004139.
Not in our library10.1371/journal.ppat.1004139
65.
Uwamahoro N., Verma-Gaur J., Shen H.-H., Qu Y., Lewis R., Lu J., Bambery K., Masters S.L., Vince J.E., Naderer T. The pathogen Candida albicans hijacks pyroptosis for escape from macrophages. mBio. 2014;5:e00003-e14.
Not in our library10.1128/mbio.00003-14
66.
Wellington M., Koselny K., Sutterwala F.S., Krysan D.J. Candida albicans triggers NLRP3-mediated pyroptosis in macrophages. Eukaryot. Cell. 2014;13:329-340.
Not in our library10.1128/ec.00336-13
67.
Global analysis of fungal morphology exposes mechanisms of host cell escape · 2015
No notice
68.
Gow N.A.R., Hube B. Importance of the Candida albicans cell wall during commensalism and infection. Curr Opin Microbiol. 2012;15:406-412.
Not in our library10.1016/j.mib.2012.04.005

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