Detection of KIT mutations in core binding factor acute myeloid leukemia
Passant Badr, Ghada M Elsayed, Dalia Negm Eldin and 2 more
Leukemia Research Reports · 2018
doi:10.1016/j.lrr.2018.06.004 (opens in a new tab)
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Abstract
We have investigated the frequency and the effect of KIT mutations on the outcome of patients with CBF-AML. 69 patients (34 pediatrics and 35 adults) with CBF-AML were enrolled in the study. The frequency of KIT mutations was higher in adults compared to pediatrics (22.9% and 14.7%, p = 0.38) respectively. Leukocytosis ≥ 20 × 109 /L was significantly associated with pediatrics compared to adults. t(8;21)(q22;22) was significantly associated with thrombocytopenia in adults. We conclude that no significant difference is found between KIT mutated and unmutated CBF-AML in adults and pediatrics. Children with CBF-AML present with leukocytosis. t(8;21) is associated with thrombocytopenia. Keywords: CBF-AML, KIT mutations, FLT-3 mutations, HRM analysis
Abstract licence: CC BY-NC
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