Ischemia-free liver transplantation. Is this the right answer to overpass organ shortage and post-liver transplant complications?

Liver transplantation (LT) results dramatically improved over the past years; nevertheless, the number of patients awaiting LT far exceeds the available grafts and waiting list mortality remains high. The use of so-called “extended criteria” donors (ECD) is proposed to improve the availability of donor allografts and reduce waiting list mortality [1]. Most ECD livers share the common denominator of being more vulnerable to ischemia-reperfusion injury (IRI) in comparison to standard grafts, hence carrying an increased risk of post-LT early allograft dysfunction (EAD), primary non-function and ischemic cholangiopathy [1, 2].

Abstract licence: CC BY-NC-ND

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