Spheroidal and nanocrystal structures created from carbodiimide crosslinking reaction with RADA16
Jorge Monreal, Robert Hyde
Journal of Science: Advanced Materials and Devices · 2017
doi:10.1016/j.jsamd.2017.05.008 (opens in a new tab)
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Abstract
RADA16 is a widely studied polypeptide known for its ability to self-assemble into β-sheets that form nanofibers. Here we show that it is possible to self-crosslink the molecule via 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) as aqueous solutions. The product results in a mix of nanocrystals and near micron-size spherules. SEM and TEM pictures provide a view of the structures and nano tracking analysis gives their size distributions. FTIR analysis provides evidence for the existence of a crosslinking reaction.
Abstract licence: CC BY-NC-ND
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