A systematic review of brief nutrition interventions in adults

Mitochondria were stained using MitoTracker Red CMXRos.One-way ANOVA followed by Tukey's test was used to determine the differences.Results: PA upregulated the expression of both IL-6 (2.1 ± 0.3; p < 0.001) and TNFa (1.7 ± 0.1; p < 0.01) relative to BSA.Additionally, L-THE decreased TNFa mRNA levels (p < 0.05), but did not downregulate IL-6 expression compared to PA treated cells (p > 0.05).PA decreased mitochondria size and density compared to BSA and this effect was ameliorated when L-THE was added alongside PA.No improvement in mitochondria density or size were observed when EGCG was used in combination with PA.Conclusions: L-THE inhibits PA-induced TNFa upregulation and can putatively ameliorate high-fat diet-induced hypothalamic inflammation and obesity.

Abstract licence: CC BY-NC-ND

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