Genomic analysis of enterovirus D68, including one strain isolated from a child with Wilson's disease in Taiwan
Yeh-Sheng Chien, Shu-Ting Luo, Kuo-Chien Tsao and 4 more
Journal of the Formosan Medical Association · 2019
doi:10.1016/j.jfma.2018.09.021 (opens in a new tab)
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Abstract
North America experienced life-threatening outbreaks of enterovirus D68 (EV-D68) in 2014. We retrospectively detected EV-D68 from a child with Wilson's disease in 2008 in Taiwan. After comparing this EV-D68/Taiwan/2008 strain with EV-D68 genomes obtained from the public domain, it was classified as genome type 1-B; it is phylogenetically related to the predominant EV-D68 viruses that circulated in 2009 in Vietnam. It is necessary to strengthen EV-D68 detection globally, including in children with acute liver failure. Moreover, harmonization of genomic analysis of EV-D68 is desirable to understand global evolution of EV-D68. Keywords: Enterovirus D68, Genome study, Molecular epidemiology, Next-generation sequencing
Abstract licence: CC BY-NC-ND
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