Protein Kinase Cβ: Linking Intestine Fibroblast Growth Factor 15 to Hepatic Extracellular Signal Regulated Kinase 1/2 Signaling in Bile Acid and Cholesterol Homeostasis

Cholesterol homeostasis is maintained by balancing cholesterol input from diet and de novo synthesis and output via conversion to bile acids in the liver and sterol hormones in steroidogenic tissues. About 50% of cholesterol is converted to bile acids, which facilitates biliary secretion of another 40% of cholesterol. Thus, bile acid synthesis and metabolism is critical for maintaining whole-body cholesterol homeostasis. Most bile acids (∼95%) in the gastrointestinal system are reabsorbed in the ileum and transported back to the liver to inhibit the transcription of cholesterol 7α-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis.

Abstract licence: CC BY-NC-ND

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