Pharmacodynamic Effects of Vorapaxar in Patients With and Without Diabetes Mellitus
Francesco Franchi, MD, Fabiana Rollini, MD, Victor Kairouz, MD and 18 more
JACC: Basic to Translational Science · 2019
doi:10.1016/j.jacbts.2019.07.011 (opens in a new tab)
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Abstract
Summary: Vorapaxar reduces thrombotic cardiovascular events at the expense of increased bleeding. However, the differential pharmacodynamic (PD) effects of vorapaxar according to diabetes mellitus (DM) status are unknown. Moreover, although withdrawal of aspirin has emerged as a bleeding reduction strategy, the PD effects of stopping aspirin in patients treated with vorapaxar also are unknown. In this prospective PD investigation, vorapaxar was associated with reduced platelet-mediated thrombogenicity without affecting clot kinetics irrespective of DM status. However, platelet-mediated thrombogenicity increased after aspirin withdrawal, particularly among patients with DM. (Optimizing anti-Platelet Therapy In diabetes MellitUS-5 Study [OPTIMUS-5]; NCT02548650) Key Words: dual antiplatelet therapy, pharmacodynamics, platelets, thrombin, vorapaxar
Abstract licence: CC BY-NC-ND
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