Prostacyclin Analogue–Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats
Shin Yajima, MD, PhD, Shigeru Miyagawa, MD, PhD, Satsuki Fukushima, MD, PhD and 12 more
JACC: Basic to Translational Science · 2019
doi:10.1016/j.jacbts.2018.12.006 (opens in a new tab)
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Abstract
Summary: Intravenously injected ONO-1301–containing nanoparticles (ONO-1301NPs), unlike an ONO-1301 solution, selectively accumulated in the ischemia/reperfusion (I/R)-injured myocardium of rats and contributed to the prolonged retention of ONO-1301 in the targeted myocardial tissue. In the ischemic area, proangiogenic cytokines were up-regulated and inflammatory cytokines were down-regulated upon ONO-1301NP administration. Consequently, ONO-1301NP–injected rats exhibited a smaller infarct size, better-preserved capillary networks, and a better-preserved myocardial blood flow at 24 h after I/R injury, compared with those in vehicle-injected or ONO-1301 solution–injected rats. ONO-1301NPs attenuate the myocardial I/R injury via proangiogenic and anti-inflammatory effects of the drug. Key Words: ischemia/reperfusion injury, nanoparticles, ONO-1301, prostacyclin
Abstract licence: CC BY-NC-ND
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