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Unilateral Carotid Body Resection in Resistant Hypertension
Krzysztof Narkiewicz, Laura E.K. Ratcliffe, Emma C. Hart and 16 more
JACC: Basic to Translational Science · 2016 · CC BY-NC-ND
doi:10.1016/j.jacbts.2016.06.004
Abstract
Animal and human data indicate pathological afferent signaling emanating from the carotid body that drives sympathetically mediated elevations in blood pressure in conditions of hypertension. This first-in-man, proof-of-principle study tested the safety and feasibility of unilateral carotid body resection in 15 patients with drug-resistant hypertension. The procedure proved to be safe and feasible. Overall, no change in blood pressure was found. However, 8 patients showed significant reductions in ambulatory blood pressure coinciding with decreases in sympathetic activity. The carotid body may be a novel target for treating an identifiable subpopulation of humans with hypertension.
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