Virological confirmation of concurrent dengue virus serotypes 1 and 4 by virus isolation using Fc-gamma receptor-expressing BHK cells
Meng Ling Moi, Yasuko Honma, Satomi Mori and 10 more
International Journal of Infectious Diseases · 2015
doi:10.1016/j.ijid.2015.02.004 (opens in a new tab)
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Abstract
Dengue virus (DENV) is estimated to infect approximately 400 million people annually. In 2014, 160 cases of autochthonous and 173 imported DENV infection cases were confirmed in Japan.1 Concurrent infection by two DENV serotypes is not an uncommon event in dengue hyperendemic areas where several DENV serotypes co-circulate.2 However, neither of the studies by previous investigators has clearly confirmed concurrent infection by virus isolation and separation.2,3 In the present study, we identified and confirmed a case of concurrent DENV-1 and DENV-4 infection in a patient by a method of virus isolation and separation for concurrent infection, using an Fc-gamma receptor (FcγR)-expressing BHK cell line.
Abstract licence: CC BY-NC-ND
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