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Manganese/NaOPh co-catalyzed C2-selective C–H conjugate addition of indoles to α,β-unsaturated carbonyls

Zelong Wang, Congyang Wang

Green Synthesis and Catalysis · 2021

doi:10.1016/j.gresc.2021.01.010 (opens in a new tab)

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Abstract

A manganese/NaOPh co-catalyzed C2-selective C–H conjugate addition of indoles to α,β-unsaturated carbonyls has been developed. The reaction features very high atom economy in which no stoichiometric reagents/additives were employed. The crucial role of sodium phenolate (NaOPh) as a synergetic catalyst was revealed in the reaction screening process and mechanistic experiments.

Abstract licence: CC BY-NC-ND

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