P41 IL-33-MEDIATED EXPANSION OF TYPE 2 INNATE LYMPHOID CELLS AMELIORATES PROGRESSIVE GLOMERULOSCLEROSIS

Chronic kidney disease (CKD) affects around 10% of the western population and is a major risk factor for cardiovascular mortality. Regardless of the type of primary injury, glomerular damage regularly results in progressive glomerulosclerosis with proteinuria and deteriorating kidney function. Over the last years, innate lymphoid cells (ILC) have been shown to play an important role in the immune system’s response to different forms of infectious and non-infectious pathologies. Especially, IL-5- and IL-13-producing type 2 ILC (ILC2) have been implicated in repair mechanisms with the aim of restoring tissue integrity after injury.

Abstract licence: CC BY-NC-ND

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