P37 ASSESING THE ROLE OF B7-1 IN DIABETIC NEPHROPATHY
M. Herrera, M. Soderberg, S. Haesman and 2 more
Kidney International Reports · 2016
doi:10.1016/j.ekir.2016.09.043 (opens in a new tab)
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Abstract
Diabetic Nephropathy (DN) remains an unmet medical challenge as its prevalence is projected to continue to increase and specific medicines for treatment remain undeveloped. Activation of the immune system, in particular T-cells, is emerging as a possible mechanism underlying DN disease progression in humans and animal models. We hypothesized that inhibition of T-cell activation will ameliorate DN. Interaction of B7-1 (CD80) on the surface of antigen presenting cells with its binding partners, CTLA4 (CD152) and CD28 on T-cells, is essential for T-cell activation.
Abstract licence: CC BY-NC-ND
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