P19 TISSUE PRIMING OF PLASMACYTOID DENDRITIC CELLS ENHANCES THEIR PHAGOCYTOSIS AND LOWERS THE THRESHOLD FOR SUBSEQUENT TOLL-LIKE RECEPTOR 9 ACTIVATION
J. Ruben, G. Garcia-Romo, E. Breman and 4 more
Kidney International Reports · 2016
doi:10.1016/j.ekir.2016.09.025 (opens in a new tab)
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Abstract
Plasmacytoid dendritic cells (pDC) have a pivotal role in clearing viral infections, and can regulate tolerance or immunity depending on their activation status. We have previously demonstrated a strong influx of pDC in the tubulointerstitium of human renal allograft rejection biopsies. In experimental transplant models, pDC were demonstrated to be activators of indirect alloreactivity, suggesting they should be able to take up donor antigens. In this study, we investigated the capacity and requirements of human pDC to ingest and present donor antigen.
Abstract licence: CC BY-NC-ND
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