Dedifferentiated endometrial adenocarcinoma with neuroendocrine differentiation and ballooning-cell features: Report of a rare entity with an unusual histology
Sara Makhdoum, MD, M. Ruhul Quddus, MD, M. Phil (Path), Michele M. Lomme, MD and 2 more
Human Pathology: Case Reports · 2019
doi:10.1016/j.ehpc.2019.01.002 (opens in a new tab)
We email you when a new notice or a question about this paper appears.
Abstract
A 63-year-old Caucasian woman underwent total hysterectomy with bilateral salpingo-oophorectomy due to abnormal uterine bleeding. Gross examination of the hysterectomy specimen revealed a large polypoid mass filling the endometrial cavity. Histological examination revealed a tumor with two unique morphologic patterns with no overlap or transition from one pattern to the other. The low-grade component consisted of FIGO grade 1 endometrioid adenocarcinoma with unusual “balloon-cell” change, while the high grade component was an undifferentiated carcinoma with neuroendocrine features. Both components exhibited MLH1 and MSH6 loss by immunohistochemistry. To our knowledge, the current case is only the 5th documented case of dedifferentiated endometrioid carcinoma with neuroendocrine features. Keywords: Endometrium, Dedifferentiated carcinoma, Neuroendocrine features, Balloon-cell change, Microsatellite instability
Abstract licence: CC BY-NC-ND
Reads
Read by people on this page
None yet.
Checked or read by AI through naulon
None yet.
A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.
Are you an author?
Is this your paper?
Claim it to add your note and be paid when agents cite it. Free.