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Host tolerance contributes to persistent viral shedding in COVID-19

De Chang, Zhu Chen, Fu-Sheng Wang and 4 more

EClinicalMedicine · 2020

doi:10.1016/j.eclinm.2020.100529 (opens in a new tab)

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Abstract

Host resistance and host tolerance are two main mechanisms by which the host responds to the infection. Host resistance refers to the ability of the host to eradicate the infection from the body by employing innate and adaptive immunity. In contrast, the host tolerance refers to the ability of the host to withstand the presence of pathogens without mounting an immune response or with a minimal immune response that is not detrimental to the host tissue [1]. Currently, it is unclear how these mechanisms play roles during current coronavirus disease 2019 (COVID-19).

Abstract licence: CC BY-NC-ND

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