Does Insulin Resistance Trigger Natriuretic Peptide Deficiency?

A number of prospective studies have suggested that obesity and type 2 diabetes (T2D) promote a state of relative natriuretic peptide (NP) deficiency, so-called “natriuretic handicap” (Das et al., 2005; Wang et al., 2004). This observation led to the hypothesis that NP deficiency contributes to the susceptibility of obese individuals to hypertension. Considering that obesity/T2D are characterized by insulin resistance and that insulin resistance is a risk factor of hypertension, it has been proposed that insulin resistance triggers NP deficiency in obesity/T2D (Khan et al., 2011).

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