Screening dataset of food components that enhance transcriptional activity of PGC1-beta
Shiho Nakai, Ran Uchitomi, Rintaro Matsuda and 3 more
Data in Brief · 2019
doi:10.1016/j.dib.2019.103814 (opens in a new tab)
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Abstract
PGC-1β is a transcriptional co-activator of nuclear receptors, which acts to increase energy expenditure. PGC-1β fused to GAL4 DNA-binding domain transfected in HEK293T cells showed a reporter luciferase activity. We screened food-derived and natural compounds using a reporter assay system to measure the transcriptional activity of PGC-1β.We found that soy-derived isoflavones, genistein and daidzein, and several resveratrols activated PGC-1β, see “Genistein, daidzein, and resveratrols stimulate PGC-1β-mediated gene expression” [1]. The list of 166 compounds and their reporter activity is shown here. Keywords: Screening, Reporter assay, Transcriptional activity
Abstract licence: CC BY-NC
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