No retraction, correction or concern found when last checked on Oct 30, 2026.
Intraciliary Calcium Oscillations Initiate Vertebrate Left-Right Asymmetry
Shiaulou Yuan, Lu Zhao, Martina Brueckner and 1 more
Current Biology · 2015
References 64
- 1.
Basu B, Brueckner M. Cilia multifunctional organelles at the center of vertebrate left-right asymmetry. Curr Top Dev Biol. 2008;85:151-174.
Not in our library10.1016/s0070-2153(08)00806-5
- 2.
- 3.
Brown NA, Wolpert L. The development of handedness in left/right asymmetry. Development. 1990;109:1-9.
Not in our library10.1242/dev.109.1.1
- 4.
Essner JJ, Amack JD, Nyholm MK, Harris EB, Yost HJ. Kupffer’s vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut. Development. 2005;132:1247-1260.
Not in our library10.1242/dev.01663
- 5.
Kramer-Zucker AG, Olale F, Haycraft CJ, Yoder BK, Schier AF, Drummond IA. Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer’s vesicle is required for normal organogenesis. Development. 2005;132:1907-1921.
Not in our library10.1242/dev.01772
- 6.
Nonaka S, Tanaka Y, Okada Y, Takeda S, Harada A, Kanai Y, Kido M, Hirokawa N. Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein [published erratum appears in Cell 1999 Oct 1;99(1):117]. Cell. 1998;95:829-837.
Not in our library10.1016/s0092-8674(00)81705-5
- 7.
Okabe N, Xu B, Burdine RD. Fluid dynamics in zebrafish Kupffer’s vesicle. Developmental dynamics: an official publication of the American Association of Anatomists. 2008;237:3602-3612.
Not in our library10.1002/dvdy.21730
- 8.
Nonaka S, Shiratori H, Saijoh Y, Hamada H. Determination of left-right patterning of the mouse embryo by artificial nodal flow. Nature. 2002;418:96-99.
Not in our library10.1038/nature00849
- 9.
McGrath J, Somlo S, Makova S, Tian X, Brueckner M. Two populations of node monocilia initiate left-right asymmetry in the mouse. Cell. 2003;114:61-73.
Not in our library10.1016/s0092-8674(03)00511-7
- 10.
Sarmah B, Latimer AJ, Appel B, Wente SR. Inositol polyphosphates regulate zebrafish left-right asymmetry. Developmental cell. 2005;9:133-145.
Not in our library10.1016/j.devcel.2005.05.002
- 11.
Tanaka Y, Okada Y, Hirokawa N. FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination. Nature. 2005;435:172-177.
Not in our library10.1038/nature03494
- 12.
Hadjantonakis AK, Pisano E, Papaioannou VE. Tbx6 regulates left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. PloS one. 2008;3:e2511.
Not in our library10.1371/journal.pone.0002511
- 13.
Nakamura T, Saito D, Kawasumi A, Shinohara K, Asai Y, Takaoka K, Dong F, Takamatsu A, Belo JA, Mochizuki A, et al. Fluid flow and interlinked feedback loops establish left-right asymmetric decay of Cerl2 mRNA. Nature communications. 2012;3:1322.
Not in our library10.1038/ncomms2319
- 14.
Yoshiba S, Shiratori H, Kuo IY, Kawasumi A, Shinohara K, Nonaka S, Asai Y, Sasaki G, Belo JA, Sasaki H, et al. Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2. Science. 2012;338:226-231.
Not in our library10.1126/science.1222538
- 15.
Takao D, Nemoto T, Abe T, Kiyonari H, Kajiura-Kobayashi H, Shiratori H, Nonaka S. Asymmetric distribution of dynamic calcium signals in the node of mouse embryo during left-right axis formation. Developmental biology. 2013;376:23-30.
Not in our library10.1016/j.ydbio.2013.01.018
- 16.
Hanaoka K, Qian F, Boletta A, Bhunia AK, Piontek K, Tsiokas L, Sukhatme VP, Guggino WB, Germino GG. Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature. 2000;408:990-994.
Not in our library10.1038/35050128
- 17.
Koulen P, Cai Y, Geng L, Maeda Y, Nishimura S, Witzgall R, Ehrlich BE, Somlo S. Polycystin-2 is an intracellular calcium release channel. Nature cell biology. 2002;4:191-197.
Not in our library10.1038/ncb754
- 18.
Pazour GJ, San Agustin JT, Follit JA, Rosenbaum JL, Witman GB. Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease. Current biology: CB. 2002;12:R378-380.
Not in our library10.1016/s0960-9822(02)00877-1
- 19.
Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, Li X, Elia AE, Lu W, Brown EM, Quinn SJ, et al. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet. 2003;33:129-137.
Not in our library10.1038/ng1076
- 20.
Pennekamp P, Karcher C, Fischer A, Schweickert A, Skryabin B, Horst J, Blum M, Dworniczak B. The ion channel polycystin-2 is required for left-right axis determination in mice. Current biology: CB. 2002;12:938-943.
Not in our library10.1016/s0960-9822(02)00869-2
- 21.
Praetorius HA, Spring KR. Bending the MDCK cell primary cilium increases intracellular calcium. J Membr Biol. 2001;184:71-79.
Not in our library10.1007/s00232-001-0075-4
- 22.
Jin X, Mohieldin AM, Muntean BS, Green JA, Shah JV, Mykytyn K, Nauli SM. Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli. Cellular and molecular life sciences: CMLS. 2013.
Not in our library10.1007/s00018-013-1483-1
- 23.
Su S, Phua SC, Derose R, Chiba S, Narita K, Kalugin PN, Katada T, Kontani K, Takeda S, Inoue T. Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia. Nature methods. 2013.
Not in our library10.1038/nmeth.2647
- 24.
Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE. Primary cilia are specialized calcium signalling organelles. Nature. 2013;504:311-314.
Not in our library10.1038/nature12833
- 25.
Caspary T, Larkins CE, Anderson KV. The graded response to Sonic Hedgehog depends on cilia architecture. Developmental cell. 2007;12:767-778.
Not in our library10.1016/j.devcel.2007.03.004
- 26.
Duldulao NA, Lee S, Sun Z. Cilia localization is essential for in vivo functions of the Joubert syndrome protein Arl13b/Scorpion. Development. 2009;136:4033-4042.
Not in our library10.1242/dev.036350
- 27.
DeCaen PG, Delling M, Vien TN, Clapham DE. Direct recording and molecular identification of the calcium channel of primary cilia. Nature. 2013;504:315-318.
Not in our library10.1038/nature12832
- 28.
Akerboom J, Chen TW, Wardill TJ, Tian L, Marvin JS, Mutlu S, Calderon NC, Esposti F, Borghuis BG, Sun XR, et al. Optimization of a GCaMP calcium indicator for neural activity imaging. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2012;32:13819-13840.
Not in our library10.1523/jneurosci.2601-12.2012
- 29.
Zhao Y, Araki S, Wu J, Teramoto T, Chang YF, Nakano M, Abdelfattah AS, Fujiwara M, Ishihara T, Nagai T, et al. An expanded palette of genetically encoded Ca(2)(+) indicators. Science. 2011;333:1888-1891.
Not in our library10.1126/science.1208592
- 30.
Leuenroth SJ, Okuhara D, Shotwell JD, Markowitz GS, Yu Z, Somlo S, Crews CM. Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease. Proceedings of the National Academy of Sciences of the United States of America. 2007;104:4389-4394.
Not in our library10.1073/pnas.0700499104
- 31.
Cantagrel V, Silhavy JL, Bielas SL, Swistun D, Marsh SE, Bertrand JY, Audollent S, Attie-Bitach T, Holden KR, Dobyns WB, et al. Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome. American journal of human genetics. 2008;83:170-179.
Not in our library10.1016/j.ajhg.2008.06.023
- 32.
Borovina A, Superina S, Voskas D, Ciruna B. Vangl2 directs the posterior tilting and asymmetric localization of motile primary cilia. Nature cell biology. 2010;12:407-412.
Not in our library10.1038/ncb2042
- 33.
Dolmetsch RE, Lewis RS. Signaling between intracellular Ca2+ stores and depletion-activated Ca2+ channels generates [Ca2+]i oscillations in T lymphocytes. The Journal of general physiology. 1994;103:365-388.
Not in our library10.1085/jgp.103.3.365
- 34.
Dolmetsch RE, Xu K, Lewis RS. Calcium oscillations increase the efficiency and specificity of gene expression. Nature. 1998;392:933-936.
Not in our library10.1038/31960
- 35.
Kreiling JA, Prabhat, Williams G, Creton R. Analysis of Kupffer’s vesicle in zebrafish embryos using a cave automated virtual environment. Developmental dynamics: an official publication of the American Association of Anatomists. 2007;236:1963-1969.
Not in our library10.1002/dvdy.21191
- 36.
Sun Z, Amsterdam A, Pazour GJ, Cole DG, Miller MS, Hopkins N. A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney. Development. 2004;131:4085-4093.
Not in our library10.1242/dev.01240
- 37.
Bisgrove BW, Snarr BS, Emrazian A, Yost HJ. Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer’s vesicle are required for specification of the zebrafish left-right axis. Dev Biol. 2005;287:274-288.
Not in our library10.1016/j.ydbio.2005.08.047
- 38.
Obara T, Mangos S, Liu Y, Zhao J, Wiessner S, Kramer-Zucker AG, Olale F, Schier AF, Drummond IA. Polycystin-2 immunolocalization and function in zebrafish. Journal of the American Society of Nephrology: JASN. 2006;17:2706-2718.
Not in our library10.1681/asn.2006040412
- 39.
Schottenfeld J, Sullivan-Brown J, Burdine RD. Zebrafish curly up encodes a Pkd2 ortholog that restricts left-side-specific expression of southpaw. Development. 2007;134:1605-1615.
Not in our library10.1242/dev.02827
- 40.
Giamarchi A, Feng S, Rodat-Despoix L, Xu Y, Bubenshchikova E, Newby LJ, Hao J, Gaudioso C, Crest M, Lupas AN, et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. The EMBO journal. 2010;29:1176-1191.
Not in our library10.1038/emboj.2010.18
- 41.
Fogelgren B, Lin SY, Zuo X, Jaffe KM, Park KM, Reichert RJ, Bell PD, Burdine RD, Lipschutz JH. The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes. PLoS genetics. 2011;7:e1001361.
Not in our library10.1371/journal.pgen.1001361
- 42.
Chen TW, Wardill TJ, Sun Y, Pulver SR, Renninger SL, Baohan A, Schreiter ER, Kerr RA, Orger MB, Jayaraman V, et al. Ultrasensitive fluorescent proteins for imaging neuronal activity. Nature. 2013;499:295-300.
Not in our library10.1038/nature12354
- 43.
Sullivan-Brown J, Schottenfeld J, Okabe N, Hostetter CL, Serluca FC, Thiberge SY, Burdine RD. Zebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants. Developmental biology. 2008;314:261-275.
Not in our library10.1016/j.ydbio.2007.11.025
- 44.
Austin-Tse C, Halbritter J, Zariwala MA, Gilberti RM, Gee HY, Hellman N, Pathak N, Liu Y, Panizzi JR, Patel-King RS, et al. Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia. American journal of human genetics. 2013;93:672-686.
Not in our library10.1016/j.ajhg.2013.08.015
- 45.
Lopes SS, Lourenco R, Pacheco L, Moreno N, Kreiling J, Saude L. Notch signalling regulates left-right asymmetry through ciliary length control. Development. 2010;137:3625-3632.
Not in our library10.1242/dev.054452
- 46.
Afzelius BA. A human syndrome caused by immotile cilia. Science. 1976;193:317-319.
Not in our library10.1126/science.1084576
- 47.
Pusl T, Wu JJ, Zimmerman TL, Zhang L, Ehrlich BE, Berchtold MW, Hoek JB, Karpen SJ, Nathanson MH, Bennett AM. Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium. J Biol Chem. 2002;277:27517-27527.
Not in our library10.1074/jbc.m203002200
- 48.
Pauls TL, Durussel I, Berchtold MW, Cox JA. Inactivation of individual Ca(2+)-binding sites in the paired EF-hand sites of parvalbumin reveals asymmetrical metal-binding properties. Biochemistry. 1994;33:10393-10400.
Not in our library10.1021/bi00200a021
- 49.
John LM, Mosquera-Caro M, Camacho P, Lechleiter JD. Control of IP(3)-mediated Ca2+ puffs in Xenopus laevis oocytes by the Ca2+-binding protein parvalbumin. The Journal of physiology. 2001;535:3-16.
Not in our library10.1111/j.1469-7793.2001.t01-2-00003.x
- 50.
Long S, Ahmad N, Rebagliati M. The zebrafish nodal-related gene southpaw is required for visceral and diencephalic left-right asymmetry. Development. 2003;130:2303-2316.
Not in our library10.1242/dev.00436
- 51.
Hashimoto H, Rebagliati M, Ahmad N, Muraoka O, Kurokawa T, Hibi M, Suzuki T. The Cerberus/Dan-family protein Charon is a negative regulator of Nodal signaling during left-right patterning in zebrafish. Development. 2004;131:1741-1753.
Not in our library10.1242/dev.01070
- 52.
Amack JD, Yost HJ. The T box transcription factor no tail in ciliated cells controls zebrafish left-right asymmetry. Current biology: CB. 2004;14:685-690.
Not in our library10.1016/j.cub.2004.04.002
- 53.
Shinohara K, Kawasumi A, Takamatsu A, Yoshiba S, Botilde Y, Motoyama N, Reith W, Durand B, Shiratori H, Hamada H. Two rotating cilia in the node cavity are sufficient to break left-right symmetry in the mouse embryo. Nature communications. 2012;3:622.
Not in our library10.1038/ncomms1624
- 54.
Kee HL, Dishinger JF, Blasius TL, Liu CJ, Margolis B, Verhey KJ. A size-exclusion permeability barrier and nucleoporins characterize a ciliary pore complex that regulates transport into cilia. Nature cell biology. 2012;14:431-437.
Not in our library10.1038/ncb2450
- 55.
Watanabe D, Saijoh Y, Nonaka S, Sasaki G, Ikawa Y, Yokoyama T, Hamada H. The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia. Development. 2003;130:1725-1734.
Not in our library10.1242/dev.00407
- 56.
Mochizuki T, Wu G, Hayashi T, Xenophontos SL, Veldhuisen B, Saris JJ, Reynolds DM, Cai Y, Gabow PA, Pierides A, et al. PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein. Science. 1996;272:1339-1342.
Not in our library10.1126/science.272.5266.1339
- 57.
Barr MM, Sternberg PW. A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans. Nature. 1999;401:386-389.
Not in our library10.1038/43913
- 58.
Gao Z, Ruden DM, Lu X. PKD2 cation channel is required for directional sperm movement and male fertility. Current biology: CB. 2003;13:2175-2178.
Not in our library10.1016/j.cub.2003.11.053
- 59.
Watnick TJ, Jin Y, Matunis E, Kernan MJ, Montell C. A flagellar polycystin-2 homolog required for male fertility in Drosophila. Current biology: CB. 2003;13:2179-2184.
Not in our library10.1016/j.cub.2003.12.002
- 60.
Dolmetsch RE, Lewis RS, Goodnow CC, Healy JI. Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Nature. 1997;386:855-858.
Not in our library10.1038/386855a0
- 61.
Uhlen P, Fritz N. Biochemistry of calcium oscillations. Biochemical and biophysical research communications. 2010;396:28-32.
Not in our library10.1016/j.bbrc.2010.02.117
- 62.
Boulware MJ, Marchant JS. Timing in cellular Ca2+ signaling. Current biology: CB. 2008;18:R769-R776.
Not in our library10.1016/j.cub.2008.07.018
- 63.
Maisonneuve C, Guilleret I, Vick P, Weber T, Andre P, Beyer T, Blum M, Constam DB. Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow. Development. 2009;136:3019-3030.
Not in our library10.1242/dev.038174
- 64.
Yuan S, Zhao L, Sun Z. Dissecting the functional interplay between the TOR pathway and the cilium in zebrafish. Methods in enzymology. 2013;525:159-189.
Not in our library10.1016/b978-0-12-397944-5.00009-2
Cited by papers we hold 4
- Chapter The Zebrafish Kupffer’s Vesicle: A Special Organ in a Model Organism to Study Human Diseases · 2020Not checked
- The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism. · 2018Not checked
- Primary Cilium-Dependent Signaling Mechanisms · 2017No notice
- Current Perspectives in Cardiac Laterality · 2016Not checked
Reads
Read by people on this page
None yet.
Checked or read by AI through naulon
None yet.
A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.
Are you an author?
Is this your paper?
Claim it to add your note and be paid when agents cite it. Free.