IodiNe Subtraction mapping in the diagnosis of Pulmonary chronIc thRomboEmbolic disease (INSPIRE): Rationale and methodology of a cross-sectional observational diagnostic study
Yousef Shahin, Christopher Johns, Kavitasagary Karunasaagarar and 2 more
Contemporary Clinical Trials Communications · 2019
doi:10.1016/j.conctc.2019.100417 (opens in a new tab)
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Abstract
Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe but treatable disease that is commonly underdiagnosed. Computed tomography lung subtraction iodine mapping (CT-LSIM) in addition to standard CT pulmonary angiography (CTPA) may improve the evaluation of suspected chronic pulmonary embolism and improve the diagnostic pick up rate. We aim to recruit 100 patients suspected of having CTEPH and perform CT-LSIM scans in addition to the current gold standard test of nuclear medicine test (lung single photon emission computed tomography (SPECT) imaging) as a pilot study which will contribute to and inform the definitive trial. The diagnostic accuracy of CT-LSIM and lung SPECT will be compared. The primary outcome of the full definitive study is non-inferiority of CT-LSIM versus lung SPECT imaging. Keywords: INSPIRE, Pulmonary embolism, Chronic thromboembolic disease, Iodine subtraction, CTLSIM
Abstract licence: CC BY-NC
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