Olfactory Stimulation Regulates the Birth of Neurons That Express Specific Odorant Receptors

In mammals, olfactory sensory neurons (OSNs) are born throughout life, ostensibly solely to replace damaged OSNs. During differentiation, each OSN precursor "chooses," out of hundreds of possibilities, a single odorant receptor (OR) gene, which defines the identity of the mature OSN. The relative neurogenesis rates of the hundreds of distinct OSN "subtypes" are thought to be constant, as they are determined by a stochastic process in which each OR is chosen with a fixed probability. Here, using histological, single-cell, and targeted affinity purification approaches, we show that closing one nostril in mice selectively reduces the number of newly generated OSNs of specific subtypes. Moreover, these reductions depend on an animal's age and/or environment. Stimulation-dependent changes in the number of new OSNs are not attributable to altered rates of cell survival but rather production. Our findings indicate that the relative birth rates of distinct OSN subtypes depend on olfactory experience.

Abstract licence: CC BY-NC-ND

1. 13.

   The activity-dependent histone variant H2BE modulates the life span of olfactory neurons · 2012

2. 36.

   Ascl1 (Mash1) Defines Cells with Long-Term Neurogenic Potential in Subgranular and Subventricular Zones in Adult Mouse Brain · 2011

3. 44.

   Trimmomatic: a flexible trimmer for Illumina sequence data · 2014

4. 55.

   Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 · 2014

5. 56.

   Olfactory sensory neurons transiently express multiple olfactory receptors during development · 2015

6. 62.

   Dynamic Axonal Translation in Developing and Mature Visual Circuits · 2016

7. 64.

   Hierarchical deconstruction of mouse olfactory sensory neurons: from whole mucosa to single-cell RNA-seq · 2015

8. 75.

   The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update · 2018

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