Maternal Lipid Metabolism Directs Fetal Liver Programming following Nutrient Stress

Summary: The extreme metabolic demands of pregnancy require coordinated metabolic adaptations between mother and fetus to balance fetal growth and maternal health with nutrient availability. To determine maternal and fetal contributions to metabolic flexibility during gestation, pregnant mice with genetic impairments in mitochondrial carbohydrate and/or lipid metabolism were subjected to nutrient deprivation. The maternal fasting response initiates a fetal liver transcriptional program marked by upregulation of lipid- and peroxisome proliferator-activated receptor alpha (Pparα)-regulated genes. Impaired maternal lipid metabolism alters circulating lipid metabolite concentrations and enhances the fetal response to fasting, which is largely dependent on fetal Pparα. Maternal fasting also improves metabolic deficits in fetal carbohydrate metabolism by increasing the availability of alternative substrates. Impairment of both carbohydrate and lipid metabolism in pregnant dams further exacerbates the fetal liver transcriptional response to nutrient deprivation. Together, these data demonstrate a regulatory role for mitochondrial macronutrient metabolism in mediating maternal-fetal metabolic communication, particularly when nutrients are limited.: Pregnancy is a time of incredible metabolic demand that necessitates metabolic communication between mother and fetus. Using multiple mouse models with impaired carbohydrate and/or fatty acid metabolism, Bowman et al. show the maternal requirements during nutrient deprivation that drive metabolic and transcriptional programming in the fetus. Keywords: metabolism, pregnancy, mitochondria, pyruvate, fatty acid oxidation, mitochondrial pyruvate carrier. MPC, carnitine palmitoyltransferase 2, Cpt2, peroxisome proliferator-activated receptor alpha, PPARα

Abstract licence: CC BY-NC

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