The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING

Cited by papers we hold 12

• cGAS–STING drives ageing-related inflammation and neurodegeneration · 2023
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• Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy · 2022
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• Mitochondrial DNA in inflammation and immunity · 2020
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• The Impact of Radiation-Induced DNA Damage on cGAS-STING-Mediated Immune Responses to Cancer · 2020
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• The interactions between cGAS-STING pathway and pathogens · 2020
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• cGAS-STING, an important pathway in cancer immunotherapy · 2020
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• Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death · 2019
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• Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1 · 2018
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• IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP · 2017
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• Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice · 2017
  Corrected
• Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response · 2016
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• Single Nucleotide Polymorphisms of Human STING Can Affect Innate Immune Response to Cyclic Dinucleotides · 2013
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