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A great potential of QPS in the field of brain stimulation

Amanda Tiksnadi, Takenobu Murakami, Winnugroho Wiratman and 1 more

Brain Stimulation · 2023

doi:10.1016/j.brs.2023.01.034 (opens in a new tab)

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Abstract

We will also report insights into the biophysical mechanism gained from ex-vivo whole-cell patch-clamp recordings. We show that TI neurostimulation involves a nonlinear subthreshold frequency conversion to the difference frequency, consistent across a broad spectrum of frequencies, ranging from a few Hz to kHz. The conversion originates in the transmembrane currents of the synaptic ligand-gated ion channels or the voltage-gated sodium channels, depending on the frequency range.

Abstract licence: CC BY-NC

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